497 research outputs found
Precise scatterer localization for ultrasound contrast imaging
This thesis is concerned with developing algorithms for the precise localization
of ultrasound point scatterers with an eye to super-resolution ultrasound contrast
imaging. In medical ultrasound, the conventional resolution is limited by diffraction
and, in contrast to other sensing fields, point source imaging has not been extensively
investigated. Here, two independent methods were proposed aiming to increase the
lateral and the axial resolution respectively, by improving the localization accuracy
of a single scatterer. The methods were examined with simulated and experimental
data by using standard transmission protocols. Where a technique is applicable to
imaging of more complicated structures than point sources, this was also examined.
Further, a preliminary study was included with algorithm application to microbubbles
that are currently used in contrast enhanced ultrasound. It was demonstrated
that it is feasible to translate to ultrasonics, adaptive processes or techniques from
optical imaging/astronomy. This way, it was possible to overcome the diffraction
limit and achieve sub-wavelength localization. The accuracy gains are subject to
many parameters but may reach up to two orders of magnitude, and are based
exclusively on array signal processing. The latter is an important advantage since
current attempts for super-resolution ultrasound are image-based which is generally
undesired
Ultrasound Signal Processing: From Models to Deep Learning
Medical ultrasound imaging relies heavily on high-quality signal processing
algorithms to provide reliable and interpretable image reconstructions.
Hand-crafted reconstruction methods, often based on approximations of the
underlying measurement model, are useful in practice, but notoriously fall
behind in terms of image quality. More sophisticated solutions, based on
statistical modelling, careful parameter tuning, or through increased model
complexity, can be sensitive to different environments. Recently, deep learning
based methods have gained popularity, which are optimized in a data-driven
fashion. These model-agnostic methods often rely on generic model structures,
and require vast training data to converge to a robust solution. A relatively
new paradigm combines the power of the two: leveraging data-driven deep
learning, as well as exploiting domain knowledge. These model-based solutions
yield high robustness, and require less trainable parameters and training data
than conventional neural networks. In this work we provide an overview of these
methods from the recent literature, and discuss a wide variety of ultrasound
applications. We aim to inspire the reader to further research in this area,
and to address the opportunities within the field of ultrasound signal
processing. We conclude with a future perspective on these model-based deep
learning techniques for medical ultrasound applications
Variable optical elements for fast focus control
In this Review, we survey recent developments in the emerging field of high-speed variable-z-focus optical elements, which are driving important innovations in advanced imaging and materials processing applications. Three-dimensional biomedical imaging, high-throughput industrial inspection, advanced spectroscopies, and other optical characterization and materials modification methods have made great strides forward in recent years due to precise and rapid axial control of light. Three state-of-the-art key optical technologies that enable fast z-focus modulation are reviewed, along with a discussion of the implications of the new developments in variable optical elements and their impact on technologically relevant applications
Photoacoustic Tomography: Principles and Advances
Photoacoustic tomography (PAT) is an emerging imaging modality that shows great potential for preclinical research and clinical practice. As a hybrid technique, PAT is based on the acoustic detection of optical absorption from either endogenous chromophores, such as oxy-hemoglobin and deoxy-hemoglobin, or exogenous contrast agents, such as organic dyes and nanoparticles. Because ultrasound scatters much less than light in tissue, PAT generates high-resolution images in both the optical ballistic and diffusive regimes. Over the past decade, the photoacoustic technique has been evolving rapidly, leading to a variety of exciting discoveries and applications. This review covers the basic principles of PAT and its different implementations. Strengths of PAT are highlighted, along with the most recent imaging results
A spatio-temporal atlas of the developing fetal brain with spina bifida aperta
Background: Spina bifida aperta (SBA) is a birth defect associated with severe anatomical changes in the developing fetal brain. Brain magnetic resonance imaging (MRI) atlases are popular tools for studying neuropathology in the brain anatomy, but previous fetal brain MRI atlases have focused on the normal fetal brain. We aimed to develop a spatio-temporal fetal brain MRI atlas for SBA.
Methods: We developed a semi-automatic computational method to compute the first spatio-temporal fetal brain MRI atlas for SBA. We used 90 MRIs of fetuses with SBA with gestational ages ranging from 21 to 35 weeks. Isotropic and motion-free 3D reconstructed MRIs were obtained for all the examinations. We propose a protocol for the annotation of anatomical landmarks in brain 3D MRI of fetuses with SBA with the aim of making spatial alignment of abnormal fetal brain MRIs more robust. In addition, we propose a weighted generalized Procrustes method based on the anatomical landmarks for the initialization of the atlas. The proposed weighted generalized Procrustes can handle temporal regularization and missing annotations. After initialization, the atlas is refined iteratively using non-linear image registration based on the image intensity and the anatomical land-marks. A semi-automatic method is used to obtain a parcellation of our fetal brain atlas into eight tissue types: white matter, ventricular system, cerebellum, extra-axial cerebrospinal fluid, cortical gray matter, deep gray matter, brainstem, and corpus callosum.
Results: An intra-rater variability analysis suggests that the seven anatomical land-marks are sufficiently reliable. We find that the proposed atlas outperforms a normal fetal brain atlas for the automatic segmentation of brain 3D MRI of fetuses with SBA.
Conclusions: We make publicly available a spatio-temporal fetal brain MRI atlas for SBA, available here: https://doi.org/10.7303/syn25887675. This atlas can support future research on automatic segmentation methods for brain 3D MRI of fetuses with SBA
A spatio-temporal atlas of the developing fetal brain with spina bifida aperta
Background: Spina bifida aperta (SBA) is a birth defect associated with severe anatomical changes in the developing fetal brain. Brain magnetic resonance imaging (MRI) atlases are popular tools for studying neuropathology in the brain anatomy, but previous fetal brain MRI atlases have focused on the normal fetal brain. We aimed to develop a spatio-temporal fetal brain MRI atlas for SBA.
Methods: We developed a semi-automatic computational method to compute the first spatio-temporal fetal brain MRI atlas for SBA. We used 90 MRIs of fetuses with SBA with gestational ages ranging from 21 to 35 weeks. Isotropic and motion-free 3D reconstructed MRIs were obtained for all the examinations. We propose a protocol for the annotation of anatomical landmarks in brain 3D MRI of fetuses with SBA with the aim of making spatial alignment of abnormal fetal brain MRIs more robust. In addition, we propose a weighted generalized Procrustes method based on the anatomical landmarks for the initialization of the atlas. The proposed weighted generalized Procrustes can handle temporal regularization and missing annotations. After initialization, the atlas is refined iteratively using non-linear image registration based on the image intensity and the anatomical land-marks. A semi-automatic method is used to obtain a parcellation of our fetal brain atlas into eight tissue types: white matter, ventricular system, cerebellum, extra-axial cerebrospinal fluid, cortical gray matter, deep gray matter, brainstem, and corpus callosum.
Results: An intra-rater variability analysis suggests that the seven anatomical land-marks are sufficiently reliable. We find that the proposed atlas outperforms a normal fetal brain atlas for the automatic segmentation of brain 3D MRI of fetuses with SBA.
Conclusions: We make publicly available a spatio-temporal fetal brain MRI atlas for SBA, available here: https://doi.org/10.7303/syn25887675. This atlas can support future research on automatic segmentation methods for brain 3D MRI of fetuses with SBA
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