19,529 research outputs found

    What is the importance of sperm subpopulations?

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    .The study of sperm subpopulations spans three decades. The origin, meaning, and practical significance, however, are less clear. Current technology for assessing sperm morphology (CASA-Morph) and motility (CASA-Mot) has enabled the accurate evaluation of these features, and there are many options for data classification. Subpopulations could occur as a result of the stage of development of each spermatozoon in the subpopulation. Spermatogenesis might contribute to the production of these subpopulations. Insights from evolutionary biology and recent molecular research are indicative of the diversity among male gametes that could occur from unequal sharing of transcripts and other elements through cytoplasmic bridges between spermatids. Sperm cohorts exiting the gonads would contain different RNA and protein contents, affecting the spermatozoon physiology and associations with the surrounding environmental milieu. Subsequently, these differences could affect how spermatozoa interact with the environmental milieu (maturation, mixing with seminal plasma, and interacting with the environmental milieu, or female genital tract and female gamete). The emergence of sperm subpopulations as an outcome of evolution, related to the reproductive strategies of the species, genital tract structures, and copulatory and fertilization processes. This kind of approach in determining the importance of sperm subpopulations in fertilization capacity should have a practical impact for conducting reproductive technologies, inspiring and enabling new ways for the more efficient use of spermatozoa in the medical, animal breeding, and conservation fields. This manuscript is a contribution to the Special Issue in memory of Dr. Duane GarnerS

    The applied psychology of addictive orientations : studies in a 12-step treatment context.

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    The clinical data for the studies was collected at The PROMIS Recovery Centre, a Minnesota Model treatmentc entre for addictions,w hich encouragesth e membership and use of the 12 step Anonymous Fellowships, and is abstinence based. The area of addiction is contextualised in a review chapter which focuses on research relating to the phenomenon of cross addiction. A study examining the concept of "addictive orientations" in male and female addicts is described, which develops a study conductedb y StephensonM, aggi, Lefever, & Morojele (1995). This presents study found a four factor solution which appeared to be subdivisions of the previously found Hedonism and Nurturance factors. Self orientated nurturance (both food dimensions, shopping and caffeine), Other orientated nurturance (both compulsive helping dimensions and work), Sensation seeking hedonism (Drugs, prescription drugs, nicotine and marginally alcohol), and Power related hedonism (Both relationship dimensions, sex and gambling. This concept of "addictive orientations" is further explored in a non-clinical population, where again a four factor solution was found, very similar to that in the clinical population. This was thought to indicate that in terms of addictive orientation a pattern already exists in this non-clinical population and that consideration should be given to why this is the case. These orientations are examined in terms of gender differences. It is suggested that the differences between genders reflect power-related role relationships between the sexes. In order to further elaborate the significance and meaning behind these orientations, the next two chapters look at the contribution of personality variables and how addictive orientations relate to psychiatric symptomatology. Personality variables were differentially, and to a considerable extent predictably involved with the four factors for both males and females.Conscientiousness as positively associated with "Other orientated Nurturance" and negatively associated with "Sensation seeking hedonism" (particularly for men). Neuroticism had a particularly strong association with the "Self orientated Nurturance" factor in the female population. More than twice the symptomatology variance was explained by the factor scores for females than it was for males. The most important factorial predictors for psychiatric symptomatology were the "Power related hedonism" factor for males, and "Self oriented nurturance" for females. The results are discussed from theoretical and treatment perspectives

    Strung pieces: on the aesthetics of television fiction series

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    As layered and long works, television fiction series have aesthetic properties that are built over time, bit by bit. This thesis develops a group of concepts that enable the study of these properties, It argues that a series is made of strung pieces, a system of related elements. The text begins by considering this sequential form within the fields of film and television. This opening chapter defines the object and methodology of research, arguing for a non-essentialist distinction between cinema and television and against the adequacy of textual and contextual analyses as approaches to the aesthetics of these shows. It proposes instead that these programmes should be described as televisual works that can be scrutinised through aesthetic analysis. The next chapters propose a sequence of interrelated concepts. The second chapter contends that series are composed of building blocks that can be either units into which series are divided or motifs that unify series and are dispersed across their pans. These blocks are patterned according to four kinds of relations or principles of composition. Repetition and variation are treated in tandem in the third chapter because of their close connection, given that variation emerges from established repetition. Exception and progression are also discussed together in the fourth chapter since they both require a long view of these serial works. The former, in order to be recognised as a deviation from the patterns of repetition and variation. The latter, In order to be understood in Its many dimensions as the series advances. Each of these concepts is further detailed with additional distinctions between types of units, motifs, repetitions, variations, and exceptions, using illustrative examples from numerous shows. In contrast, the section on progression uses a single series as case study, CarnivĂ le (2003-05), because this is the overarching principle that encompasses all the others. The conclusion considers the findings of the research and suggests avenues for their application

    Study of models for the nominal power characterization of a photovoltaic generator and the power estimation of different photovoltaic technologies in Lima, Peru

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    This work investigates two main aspects related to photovoltaic: systems and module characterization and performance modeling. The first part aims to characterize a PV generator located in Spain with a nominal power of 109.44 kW under standard test conditions according to the datasheet. An operational photovoltaic system's nominal power is a valid parameter for determining its current operational state. The applicability of a standard procedure to estimate the nominal power of an operating generator, proposed by MartĂ­nez-Moreno and based on Osterwald's model, is investigated. However, the standard procedure does not specify how to deal with experimental data when unexpected behavior impedes the nominal power estimation under operating conditions. During the 6-month study, the power-irradiance relation showed a hysteresis effect with varying amplitudes throughout the campaign. Adding a data filter that removes the non-linear part of the data proves necessary to estimate the nominal power, complementing Martinez-Moreno's procedure to enable the generators' characterization. The second part contributes to closing a knowledge gap in the performance behavior and predictability of multiple PV technologies in Peru. The quality of two simple analytical models for estimating the outdoor performance of three different photovoltaic module technologies in Lima was investigated. Osterwald's and the Constant Fill Factor models were applied to estimate the maximum power delivered by an Aluminum Back Surface Field, a Heterojunction with Intrinsic Thin-layer, and an amorphous/microcrystalline thin-film tandem PV module. The results point that both models overestimate the expected power compared to the measured one. Implementing a correction factor adjusts the estimated maximum power by both models. This correction factor allows us to estimate losses, calculate an adequate nominal power and minimize the estimated power error. The normalized root mean square error and mean bias error determine the implemented methodology's quality. The two crystalline silicon-based technologies present a similar behavior throughout the year. However, both differ considerably from the tandem one during different months, implying that the ambient variables have other seasonal impacts on their performance

    Facial expression recognition and intensity estimation.

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    Doctoral Degree. University of KwaZulu-Natal, Durban.Facial Expression is one of the profound non-verbal channels through which human emotion state is inferred from the deformation or movement of face components when facial muscles are activated. Facial Expression Recognition (FER) is one of the relevant research fields in Computer Vision (CV) and Human-Computer Interraction (HCI). Its application is not limited to: robotics, game, medical, education, security and marketing. FER consists of a wealth of information. Categorising the information into primary emotion states only limit its performance. This thesis considers investigating an approach that simultaneously predicts the emotional state of facial expression images and the corresponding degree of intensity. The task also extends to resolving FER ambiguous nature and annotation inconsistencies with a label distribution learning method that considers correlation among data. We first proposed a multi-label approach for FER and its intensity estimation using advanced machine learning techniques. According to our findings, this approach has not been considered for emotion and intensity estimation in the field before. The approach used problem transformation to present FER as a multilabel task, such that every facial expression image has unique emotion information alongside the corresponding degree of intensity at which the emotion is displayed. A Convolutional Neural Network (CNN) with a sigmoid function at the final layer is the classifier for the model. The model termed ML-CNN (Multilabel Convolutional Neural Network) successfully achieve concurrent prediction of emotion and intensity estimation. ML-CNN prediction is challenged with overfitting and intraclass and interclass variations. We employ Visual Geometric Graphics-16 (VGG-16) pretrained network to resolve the overfitting challenge and the aggregation of island loss and binary cross-entropy loss to minimise the effect of intraclass and interclass variations. The enhanced ML-CNN model shows promising results and outstanding performance than other standard multilabel algorithms. Finally, we approach data annotation inconsistency and ambiguity in FER data using isomap manifold learning with Graph Convolutional Networks (GCN). The GCN uses the distance along the isomap manifold as the edge weight, which appropriately models the similarity between adjacent nodes for emotion predictions. The proposed method produces a promising result in comparison with the state-of-the-art methods.Author's List of Publication is on page xi of this thesis

    The application of Evidence-Based Medicine methodologies in sports science: problems and solutions

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    This thesis analyses the use of 'Evidence-Based' methodologies of evidence assessment and intervention and policy design from medicine, and their use in sport and exercise science. It argues that problems exist with the application of Evidence-Based methodologies in sports science, meaning that the quality of evidence used to inform decision-making is lower than is often assumed. This thesis also offers realistic solutions to these problems, broadly arguing for the importance of taking evidence from mechanistic studies seriously, in addition to evidence from RCTs

    Mobility of public researchers, scientific knowledge transfer, and the firm's innovation process

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    The present study provides evidence on the mobility effects of researchers from the public R&D system with regard to firm´s innovation process. This issue is particularly novel and important as these researchers contribute to the production and transfer of knowledge previously developed and accumulated in the public R&D system. The findings confirm that scientific knowledge which public researchers provide has a positive influence on both inputs and outputs of the firms’ innovation process. The fact that firms have access to additional knowledge which is complementary to that they already hold represents a spur for exploiting and applying this new knowledge. The firms in this study continually increased their in-house R&D investments. As a result of these investments firms create new knowledge of a unique and valuable type. The study draws two important conclusions geared to providing a greater efficiency in human resource management and to improve the design of technology policies

    Viability of patent insurance in Spain

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    M-24609-2013Since 1975 the FUNDACIÓN MAPFRE has involved itself in activities serving the general interests of society in different areas of business and culture along with activities aimed at improving the economic and social conditions of the least advantaged members and sectors of society. Within this framework, the FUNDACIÓN MAPFRE’s Institute of Insurance Science promotes and undertakes educational and research activities in the fields of insurance and risk management. In the area of education, its activities include specialized, post-graduate academic training carried out in association with the Pontifical University of Salamanca and courses and seminars for professionals held in Spain and Latin America. These activities have been expanded into other geographic regions thanks to cooperation with a series of institutions in Spain and other countries and an Internet training programme. The Institute offers grants for research in risk and insurance science and operates a specialized insurance and risk management Documentation Centre as support for its activities. The Institute routinely sponsors and draws up reports and publishes books dealing with insurance and risk management to improve our understanding of these fields. Some are intended as reference materials for those starting out in the study or practice of insurance affairs, while others are intended as information sources for undertaking research into specialized issues in greater depth. One of these activities is the publication of this volume, the outcome of research carried out by Drs. Pérez Carrillo and Cuypers in 2011 and 2012, under the guidance of José Antonio Aventín Arroyo

    Spattered with Words: a stylistic toolkit accounting for the 'theatricality' behind the playwright/screenwriter's use of real and improvised language in creating drama texts.

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    This thesis documents investigations into the success (or not) of real, spontaneous dialogue when applied to the creation of a script for dramatic performance. The accounting for such success delves into different theoretical frameworks: conversation theory, stylistics, Cognitive Poetics, narratology, and extended cognition. This is therefore an interdisciplinary perspective, with ideas emerging from the fields of psychology, philosophy, literary stylistics and linguistics; yet all applied within the context of drama and performance. As such, this thesis may be seen as a playwright's 'toolbox' where the different views, as they necessarily overlap, can be seen as elements, which, when taken together, account for (and help in) the decisions an author may make in creating a text out of improvised speech. The investigation is also a search for the notion of 'theatricality' in the context of authentic speech and uses various forms of theatrical performance as examples, ranging from amateur improvisation to TV and film productions, Commedia dell'Arte to modern, immersive theatre. Finally, application of the theoretical frameworks is made to a current theatre project, The Plant

    New models involving quantum chemical parameters for assessing the chromatographic retention process

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    .Knowledge about the theoretical relationship between the analyte properties and the critical chromatographic parameters is mandatory for a better interpretation of the separation mechanism and a more leisurely development of quantitative studies. In a preliminary stage of this work, we introduce the Gumbel distribution, the extreme value distribution type-I widely used in other fields, as a novel tool for modelling the chromatographic peak shape. Further, we develop mathematical models to evaluate the effect of the experimental variables and various quantum parameters on the chromatographic indices, such as the retention time, capacity factor, asymmetry factor, tailing factor and number of theoretical plates. Finally, we propose a mechanistic behaviour for the chromatographic separation process based on the structure-retention relationship of fifteen selected drugs involving several molecular quantum parametersS
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