Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene

In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event

Pointlike structure for super p-branes

We present an efficient method to understand the p-brane dynamics in a unified framework. For this purpose, we reformulate the action for super p-branes in the form appropriate to incorporate the pointlike (parton) structure of higher dimensional p-branes and intend to interpret the p-brane dynamics as the collective dynamics of superparticles. In order to examine such a parton picture of super p-branes, we consider various superparticle configurations that can be reduced from super p-branes, especially, a supermembrane, and study the partonic structure of classical p-brane solutions.Comment: 22 pages, corrected typos, to appear in Phys. Rev. D58, 085018 (1998

The rare decays B --> K(*) anti-K(*) and R-parity violating supersymmetry

We study the branching ratios, the direct CP asymmetries in $B\to K^{(*)}\bar{K}^{(*)}$ decays and the polarization fractions of $B\to K^{*}\bar{K}^{*}$ decays by employing the QCD factorization in the minimal supersymmetric standard model with R-parity violation. We derive the new upper bounds on the relevant R-parity violating couplings from the latest experimental data of $B\to K^{(*)}\bar{K}^{(*)}$, and some of these constraints are stronger than the existing bounds. Using the constrained parameter spaces, we predict the R-parity violating effects on the other quantities in $B\to K^{(*)}\bar{K}^{(*)}$ decays which have not been measured yet. We find that the R-parity violating effects on the branching ratios and the direct $CP$ asymmetries could be large, nevertheless their effects on the longitudinal polarizations of $B\to K^{*}\bar{K}^{*}$ decays are small. Near future experiments can test these predictions and shrink the parameter spaces.Comment: 31 pages with 10 figure

Pareto improving social security reform when financial markets are incomplete!?

This paper studies an overlapping generations model with stochastic production and incomplete markets to assess whether the introduction of an unfunded social security system leads to a Pareto improvement. When returns to capital and wages are imperfectly correlated a system that endows retired households with claims to labor income enhances the sharing of aggregate risk between generations. Our quantitative analysis shows that, abstracting from the capital crowding-out effect, the introduction of social security represents a Pareto improving reform, even when the economy is dynamically effcient. However, the severity of the crowding-out effect in general equilibrium tends to overturn these gains. Klassifikation: E62, H55, H31, D91, D58 . April 2005

Irrotational binary neutron stars in quasiequilibrium

We report on numerical results from an independent formalism to describe the quasi-equilibrium structure of nonsynchronous binary neutron stars in general relativity. This is an important independent test of controversial numerical hydrodynamic simulations which suggested that nonsynchronous neutron stars in a close binary can experience compression prior to the last stable circular orbit. We show that, for compact enough stars the interior density increases slightly as irrotational binary neutron stars approach their last orbits. The magnitude of the effect, however, is much smaller than that reported in previous hydrodynamic simulations.Comment: 4 pages, 2 figures, revtex, accepted for publication in Phys. Rev.

Reforming the EU Sugar Policy

This article presents and analyses the impacts of the EU sugar policy. Particular attention is given to the modelling of the quite complex policy and the calibration of the global general equilibrium model at the member state level. Two scenarios are analysed, namely a reduction in the intervention price of sugar and the sugar quota. It is found that the economic impacts of the two scenarios are quite different in terms of the effects on European production and trade in sugar as well in terms of efficiency. The impacts for developing countries also differ considerably across the two scenarios.EU sugar policy, general equilibrium modelling, reform scenarios, Agricultural and Food Policy, C68, D58, Q17, Q18,

The structures of Micrococcus lysodeikticus catalase, its ferryl intermediate (compound II) and NADPH complex

The crystal structure of the bacterial catalase from Micrococcus lysodeikticus has been refined using the gene-derived sequence both at 0.88 Angstrom resolution using data recorded at 110 K and at 1.5 Angstrom resolution with room-temperature data. The atomic resolution structure has been refined with individual anisotropic atomic thermal parameters. This has revealed the geometry of the haem and surrounding protein, including many of the H atoms, with unprecedented accuracy and has characterized functionally important hydrogen-bond interactions in the active site. The positions of the H atoms are consistent with the enzymatic mechanism previously suggested for beef liver catalase. The structure reveals that a 25 Angstrom long channel leading to the haem is filled by partially occupied water molecules, suggesting an inherent facile access to the active site. In addition, the structures of the ferryl intermediate of the catalase, the so-called compound II, at 1.96 Angstrom resolution and the catalase complex with NADPH at 1.83 Angstrom resolution have been determined. Comparison of compound II and the resting state of the enzyme shows that the binding of the O atom to the iron (bond length 1.87 Angstrom) is associated with increased haem bending and is accompanied by a distal movement of the iron and the side chain of the proximal tyrosine. Finally, the structure of the NADPH complex shows that the cofactor is bound to the molecule in an equivalent position to that found in beef liver catalase, but that only the adenine part of NADPH is visible in the present structure