Fuzzy Sets in Business Management, Finance, and Economics

This book collects fifteen papers published in s Special Issue of Mathematics titled “Fuzzy Sets in Business Management, Finance, and Economics”, which was published in 2021. These paper cover a wide range of different tools from Fuzzy Set Theory and applications in many areas of Business Management and other connected fields. Specifically, this book contains applications of such instruments as, among others, Fuzzy Set Qualitative Comparative Analysis, Neuro-Fuzzy Methods, the Forgotten Effects Algorithm, Expertons Theory, Fuzzy Markov Chains, Fuzzy Arithmetic, Decision Making with OWA Operators and Pythagorean Aggregation Operators, Fuzzy Pattern Recognition, and Intuitionistic Fuzzy Sets. The papers in this book tackle a wide variety of problems in areas such as strategic management, sustainable decisions by firms and public organisms, tourism management, accounting and auditing, macroeconomic modelling, the evaluation of public organizations and universities, and actuarial modelling. We hope that this book will be useful not only for business managers, public decision-makers, and researchers in the specific fields of business management, finance, and economics but also in the broader areas of soft mathematics in social sciences. Practitioners will find methods and ideas that could be fruitful in current management issues. Scholars will find novel developments that may inspire further applications in the social sciences

A review of the leader approach for delivering the rural development programme for England: a report for Defra

This report, commissioned by the Rural Communities Policy Unit at Defra, sets out the findings of a review of the Leader approach in England. The focus of the review is the impact of Leader in contributing to the delivery of the Rural Development Programme (RDP) in England, in order to inform the future Leader approach to delivering rural policy. The research is primarily based on a review of existing literature and in-depth qualitative research with Local Action Groups and other stakeholders involved in delivering or benefiting from the Leader approach. The review focuses on four key issues: 1) Evidence to support the rationale for use of EU resources to enable rural development – justifying intervention for the current programme and informing choices about interventions in the next programme 2) Evidence on the extent to which interventions have been effective to date and where future resources can be targeted 3) Evidence to provide an assessment of the impact of RDPE spend (2007-13) on outcomes – with reference to delivery mechanisms 4) Evidence to support prioritisation of activities to be funded under the next programme mapped against the six EU wide priorities for 2014-2020 and inform decisions about future delivery models

Les Houches 2013: Physics at TeV Colliders: Standard Model Working Group Report

This Report summarizes the proceedings of the 2013 Les Houches workshop on Physics at TeV Colliders. Session 1 dealt primarily with (1) the techniques for calculating standard model multi-leg NLO and NNLO QCD and NLO EW cross sections and (2) the comparison of those cross sections with LHC data from Run 1, and projections for future measurements in Run 2.Comment: Proceedings of the Standard Model Working Group of the 2013 Les Houches Workshop, Physics at TeV Colliders, Les houches 3-21 June 2013. 200 page

Functional and structural MRI image analysis for brain glial tumors treatment

Cotutela con il Dipartimento di Biotecnologie e Scienze della Vita, Universiità degli Studi dell'Insubria.openThis Ph.D Thesis is the outcome of a close collaboration between the Center for Research in Image Analysis and Medical Informatics (CRAIIM) of the Insubria University and the Operative Unit of Neurosurgery, Neuroradiology and Health Physics of the University Hospital ”Circolo Fondazione Macchi”, Varese. The project aim is to investigate new methodologies by means of whose, develop an integrated framework able to enhance the use of Magnetic Resonance Images, in order to support clinical experts in the treatment of patients with brain Glial tumor. Both the most common uses of MRI technology for non-invasive brain inspection were analyzed. From the Functional point of view, the goal has been to provide tools for an objective reliable and non-presumptive assessment of the brain’s areas locations, to preserve them as much as possible at surgery. From the Structural point of view, methodologies for fully automatic brain segmentation and recognition of the tumoral areas, for evaluating the tumor volume, the spatial distribution and to be able to infer correlation with other clinical data or trace growth trend, have been studied. Each of the proposed methods has been thoroughly assessed both qualitatively and quantitatively. All the Medical Imaging and Pattern Recognition algorithmic solutions studied for this Ph.D. Thesis have been integrated in GliCInE: Glioma Computerized Inspection Environment, which is a MATLAB prototype of an integrated analysis environment that offers, in addition to all the functionality specifically described in this Thesis, a set of tools needed to manage Functional and Structural Magnetic Resonance Volumes and ancillary data related to the acquisition and the patient.openInformaticaPedoia, ValentinaPedoia, Valentin

Methods for the Analysis of Matched Molecular Pairs and Chemical Space Representations

Compound optimization is a complex process where different properties are optimized to increase the biological activity and therapeutic effects of a molecule. Frequently, the structure of molecules is modified in order to improve their property values. Therefore, computational analysis of the effects of structure modifications on property values is of great importance for the drug discovery process. It is also essential to analyze chemical space, i.e., the set of all chemically feasible molecules, in order to find subsets of molecules that display favorable property values. This thesis aims to expand the computational repertoire to analyze the effect of structure alterations and visualize chemical space. Matched molecular pairs are defined as pairs of compounds that share a large common substructure and only differ by a small chemical transformation. They have been frequently used to study property changes caused by structure modifications. These analyses are expanded in this thesis by studying the effect of chemical transformations on the ionization state and ligand efficiency, both measures of great importance in drug design. Additionally, novel matched molecular pairs based on retrosynthetic rules are developed to increase their utility for prospective use of chemical transformations in compound optimization. Further, new methods based on matched molecular pairs are described to obtain preliminary SAR information of screening hit compounds and predict the potency change caused by a chemical transformation. Visualizations of chemical space are introduced to aid compound optimization efforts. First, principal component plots are used to rationalize a matched molecular pair based multi-objective compound optimization procedure. Then, star coordinate and parallel coordinate plots are introduced to analyze drug-like subspaces, where compounds with favorable property values can be found. Finally, a novel network-based visualization of high-dimensional property space is developed. Concluding, the applications developed in this thesis expand the methodological spectrum of computer-aided compound optimization

Mathematical Methods and Operation Research in Logistics, Project Planning, and Scheduling

In the last decade, the Industrial Revolution 4.0 brought flexible supply chains and flexible design projects to the forefront. Nevertheless, the recent pandemic, the accompanying economic problems, and the resulting supply problems have further increased the role of logistics and supply chains. Therefore, planning and scheduling procedures that can respond flexibly to changed circumstances have become more valuable both in logistics and projects. There are already several competing criteria of project and logistic process planning and scheduling that need to be reconciled. At the same time, the COVID-19 pandemic has shown that even more emphasis needs to be placed on taking potential risks into account. Flexibility and resilience are emphasized in all decision-making processes, including the scheduling of logistic processes, activities, and projects