485 research outputs found
Deep Learning based HEp-2 Image Classification: A Comprehensive Review
Classification of HEp-2 cell patterns plays a significant role in the
indirect immunofluorescence test for identifying autoimmune diseases in the
human body. Many automatic HEp-2 cell classification methods have been proposed
in recent years, amongst which deep learning based methods have shown
impressive performance. This paper provides a comprehensive review of the
existing deep learning based HEp-2 cell image classification methods. These
methods perform HEp-2 image classification at two levels, namely, cell-level
and specimen-level. Both levels are covered in this review. At each level, the
methods are organized with a deep network usage based taxonomy. The core idea,
notable achievements, and key strengths and weaknesses of each method are
critically analyzed. Furthermore, a concise review of the existing HEp-2
datasets that are commonly used in the literature is given. The paper ends with
a discussion on novel opportunities and future research directions in this
field. It is hoped that this paper would provide readers with a thorough
reference of this novel, challenging, and thriving field.Comment: Published in Medical Image Analysi
Cats or CAT scans: transfer learning from natural or medical image source datasets?
Transfer learning is a widely used strategy in medical image analysis.
Instead of only training a network with a limited amount of data from the
target task of interest, we can first train the network with other, potentially
larger source datasets, creating a more robust model. The source datasets do
not have to be related to the target task. For a classification task in lung CT
images, we could use both head CT images, or images of cats, as the source.
While head CT images appear more similar to lung CT images, the number and
diversity of cat images might lead to a better model overall. In this survey we
review a number of papers that have performed similar comparisons. Although the
answer to which strategy is best seems to be "it depends", we discuss a number
of research directions we need to take as a community, to gain more
understanding of this topic.Comment: Accepted to Current Opinion in Biomedical Engineerin
A Survey on Deep Learning in Medical Image Analysis
Deep learning algorithms, in particular convolutional networks, have rapidly
become a methodology of choice for analyzing medical images. This paper reviews
the major deep learning concepts pertinent to medical image analysis and
summarizes over 300 contributions to the field, most of which appeared in the
last year. We survey the use of deep learning for image classification, object
detection, segmentation, registration, and other tasks and provide concise
overviews of studies per application area. Open challenges and directions for
future research are discussed.Comment: Revised survey includes expanded discussion section and reworked
introductory section on common deep architectures. Added missed papers from
before Feb 1st 201
Interpretation of immunofluorescence slides by deep learning techniques: anti-nuclear antibodies case study
Nowadays, diseases are increasing in numbers and severity by the hour.
Immunity diseases, affecting 8\% of the world population in 2017 according to
the World Health Organization (WHO), is a field in medicine worth attention due
to the high rate of disease occurrence classified under this category. This
work presents an up-to-date review of state-of-the-art immune diseases
healthcare solutions. We focus on tackling the issue with modern solutions such
as Deep Learning to detect anomalies in the early stages hence providing health
practitioners with efficient tools. We rely on advanced deep learning
techniques such as Convolutional Neural Networks (CNN) to fulfill our objective
of providing an efficient tool while providing a proficient analysis of this
solution. The proposed solution was tested and evaluated by the immunology
department in the Principal Military Hospital of Instruction of Tunis, which
considered it a very helpful tool
Multi-branch Convolutional Neural Network for Multiple Sclerosis Lesion Segmentation
In this paper, we present an automated approach for segmenting multiple
sclerosis (MS) lesions from multi-modal brain magnetic resonance images. Our
method is based on a deep end-to-end 2D convolutional neural network (CNN) for
slice-based segmentation of 3D volumetric data. The proposed CNN includes a
multi-branch downsampling path, which enables the network to encode information
from multiple modalities separately. Multi-scale feature fusion blocks are
proposed to combine feature maps from different modalities at different stages
of the network. Then, multi-scale feature upsampling blocks are introduced to
upsize combined feature maps to leverage information from lesion shape and
location. We trained and tested the proposed model using orthogonal plane
orientations of each 3D modality to exploit the contextual information in all
directions. The proposed pipeline is evaluated on two different datasets: a
private dataset including 37 MS patients and a publicly available dataset known
as the ISBI 2015 longitudinal MS lesion segmentation challenge dataset,
consisting of 14 MS patients. Considering the ISBI challenge, at the time of
submission, our method was amongst the top performing solutions. On the private
dataset, using the same array of performance metrics as in the ISBI challenge,
the proposed approach shows high improvements in MS lesion segmentation
compared with other publicly available tools.Comment: This paper has been accepted for publication in NeuroImag
Deep Active Learning for Automatic Mitotic Cell Detection on HEp-2 Specimen Medical Images
Identifying Human Epithelial Type 2 (HEp-2) mitotic cells is a crucial procedure in anti-nuclear antibodies (ANAs) testing, which is the standard protocol for detecting connective tissue diseases (CTD). Due to the low throughput and labor-subjectivity of the ANAs' manual screening test, there is a need to develop a reliable HEp-2 computer-aided diagnosis (CAD) system. The automatic detection of mitotic cells from the microscopic HEp-2 specimen images is an essential step to support the diagnosis process and enhance the throughput of this test. This work proposes a deep active learning (DAL) approach to overcoming the cell labeling challenge. Moreover, deep learning detectors are tailored to automatically identify the mitotic cells directly in the entire microscopic HEp-2 specimen images, avoiding the segmentation step. The proposed framework is validated using the I3A Task-2 dataset over 5-fold cross-validation trials. Using the YOLO predictor, promising mitotic cell prediction results are achieved with an average of 90.011% recall, 88.307% precision, and 81.531% mAP. Whereas, average scores of 86.986% recall, 85.282% precision, and 78.506% mAP are obtained using the Faster R-CNN predictor. Employing the DAL method over four labeling rounds effectively enhances the accuracy of the data annotation, and hence, improves the prediction performance. The proposed framework could be practically applicable to support medical personnel in making rapid and accurate decisions about the mitotic cells' existence
On Improving Generalization of CNN-Based Image Classification with Delineation Maps Using the CORF Push-Pull Inhibition Operator
Deployed image classification pipelines are typically dependent on the images captured in real-world environments. This means that images might be affected by different sources of perturbations (e.g. sensor noise in low-light environments). The main challenge arises by the fact that image quality directly impacts the reliability and consistency of classification tasks. This challenge has, hence, attracted wide interest within the computer vision communities. We propose a transformation step that attempts to enhance the generalization ability of CNN models in the presence of unseen noise in the test set. Concretely, the delineation maps of given images are determined using the CORF push-pull inhibition operator. Such an operation transforms an input image into a space that is more robust to noise before being processed by a CNN. We evaluated our approach on the Fashion MNIST data set with an AlexNet model. It turned out that the proposed CORF-augmented pipeline achieved comparable results on noise-free images to those of a conventional AlexNet classification model without CORF delineation maps, but it consistently achieved significantly superior performance on test images perturbed with different levels of Gaussian and uniform noise
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