Rich probabilistic models for semantic labeling

Das Ziel dieser Monographie ist es die Methoden und Anwendungen des semantischen Labelings zu erforschen. Unsere Beiträge zu diesem sich rasch entwickelten Thema sind bestimmte Aspekte der Modellierung und der Inferenz in probabilistischen Modellen und ihre Anwendungen in den interdisziplinären Bereichen der Computer Vision sowie medizinischer Bildverarbeitung und Fernerkundung

Intraoperative Navigation Systems for Image-Guided Surgery

Recent technological advancements in medical imaging equipment have resulted in a dramatic improvement of image accuracy, now capable of providing useful information previously not available to clinicians. In the surgical context, intraoperative imaging provides a crucial value for the success of the operation. Many nontrivial scientific and technical problems need to be addressed in order to efficiently exploit the different information sources nowadays available in advanced operating rooms. In particular, it is necessary to provide: (i) accurate tracking of surgical instruments, (ii) real-time matching of images from different modalities, and (iii) reliable guidance toward the surgical target. Satisfying all of these requisites is needed to realize effective intraoperative navigation systems for image-guided surgery. Various solutions have been proposed and successfully tested in the field of image navigation systems in the last ten years; nevertheless several problems still arise in most of the applications regarding precision, usability and capabilities of the existing systems. Identifying and solving these issues represents an urgent scientific challenge. This thesis investigates the current state of the art in the field of intraoperative navigation systems, focusing in particular on the challenges related to efficient and effective usage of ultrasound imaging during surgery. The main contribution of this thesis to the state of the art are related to: Techniques for automatic motion compensation and therapy monitoring applied to a novel ultrasound-guided surgical robotic platform in the context of abdominal tumor thermoablation. Novel image-fusion based navigation systems for ultrasound-guided neurosurgery in the context of brain tumor resection, highlighting their applicability as off-line surgical training instruments. The proposed systems, which were designed and developed in the framework of two international research projects, have been tested in real or simulated surgical scenarios, showing promising results toward their application in clinical practice

REAL-TIME 4D ULTRASOUND RECONSTRUCTION FOR IMAGE-GUIDED INTRACARDIAC INTERVENTIONS

Image-guided therapy addresses the lack of direct vision associated with minimally- invasive interventions performed on the beating heart, but requires effective intraoperative imaging. Gated 4D ultrasound reconstruction using a tracked 2D probe generates a time-series of 3D images representing the beating heart over the cardiac cycle. These images have a relatively high spatial resolution and wide field of view, and ultrasound is easily integrated into the intraoperative environment. This thesis presents a real-time 4D ultrasound reconstruction system incorporated within an augmented reality environment for surgical guidance, whose incremental visualization reduces common acquisition errors. The resulting 4D ultrasound datasets are intended for visualization or registration to preoperative images. A human factors experiment demonstrates the advantages of real-time ultrasound reconstruction, and accuracy assessments performed both with a dynamic phantom and intraoperatively reveal RMS localization errors of 2.5-2.7 mm, and 0.8 mm, respectively. Finally, clinical applicability is demonstrated by both porcine and patient imaging

Ultrasound imaging system combined with multi-modality image analysis algorithms to monitor changes in anatomical structures

This dissertation concerns the development and validation of an ultrasound imaging system and novel image analysis algorithms applicable to multiple imaging modalities. The ultrasound imaging system will include a framework for 3D volume reconstruction of freehand ultrasound: a mechanism to register the 3D volumes across time and subjects, as well as with other imaging modalities, and a playback mechanism to view image slices concurrently from different acquisitions that correspond to the same anatomical region. The novel image analysis algorithms include a noise reduction method that clusters pixels into homogenous patches using a directed graph of edges between neighboring pixels, a segmentation method that creates a hierarchical graph structure using statistical analysis and a voting system to determine the similarity between homogeneous patches given their neighborhood, and finally, a hybrid atlas-based registration method that makes use of intensity corrections induced at anatomical landmarks to regulate deformable registration. The combination of the ultrasound imaging system and the image analysis algorithms will provide the ability to monitor nerve regeneration in patients undergoing regenerative, repair or transplant strategies in a sequential, non-invasive manner, including visualization of registered real-time and pre-acquired data, thus enabling preventive and therapeutic strategies for nerve regeneration in Composite Tissue Allotransplantation (CTA). The registration algorithm is also applied to MR images of the brain to obtain reliable and efficient segmentation of the hippocampus, which is a prominent structure in the study of diseases of the elderly such as vascular dementia, Alzheimer’s, and late life depression. Experimental results on 2D and 3D images, including simulated and real images, with illustrations visualizing the intermediate outcomes and the final results are presented.

Globally-Coordinated Locally-Linear Modeling of Multi-Dimensional Data

This thesis considers the problem of modeling and analysis of continuous, locally-linear, multi-dimensional spatio-temporal data. Our work extends the previously reported theoretical work on the global coordination model to temporal analysis of continuous, multi-dimensional data. We have developed algorithms for time-varying data analysis and used them in full-scale, real-world applications. The applications demonstrated in this thesis include tracking, synthesis, recognitions and retrieval of dynamic objects based on their shape, appearance and motion. The proposed approach in this thesis has advantages over existing approaches to analyzing complex spatio-temporal data. Experiments show that the new modeling features of our approach improve the performance of existing approaches in many applications. In object tracking, our approach is the first one to track nonlinear appearance variations by using low-dimensional representation of the appearance change in globally-coordinated linear subspaces. In dynamic texture synthesis, we are able to model non-stationary dynamic textures, which cannot be handled by any of the existing approaches. In human motion synthesis, we show that realistic synthesis can be performed without using specific transition points, or key frames

Virtual Reality Aided Mobile C-arm Positioning for Image-Guided Surgery

Image-guided surgery (IGS) is the minimally invasive procedure based on the pre-operative volume in conjunction with intra-operative X-ray images which are commonly captured by mobile C-arms for the confirmation of surgical outcomes. Although currently some commercial navigation systems are employed, one critical issue of such systems is the neglect regarding the radiation exposure to the patient and surgeons. In practice, when one surgical stage is finished, several X-ray images have to be acquired repeatedly by the mobile C-arm to obtain the desired image. Excessive radiation exposure may increase the risk of some complications. Therefore, it is necessary to develop a positioning system for mobile C-arms, and achieve one-time imaging to avoid the additional radiation exposure. In this dissertation, a mobile C-arm positioning system is proposed with the aid of virtual reality (VR). The surface model of patient is reconstructed by a camera mounted on the mobile C-arm. A novel registration method is proposed to align this model and pre-operative volume based on a tracker, so that surgeons can visualize the hidden anatomy directly from the outside view and determine a reference pose of C-arm. Considering the congested operating room, the C-arm is modeled as manipulator with a movable base to maneuver the image intensifier to the desired pose. In the registration procedure above, intensity-based 2D/3D registration is used to transform the pre-operative volume into the coordinate system of tracker. Although it provides a high accuracy, the small capture range hinders its clinical use due to the initial guess. To address such problem, a robust and fast initialization method is proposed based on the automatic tracking based initialization and multi-resolution estimation in frequency domain. This hardware-software integrated approach provides almost optimal transformation parameters for intensity-based registration. To determine the pose of mobile C-arm, high-quality visualization is necessary to locate the pathology in the hidden anatomy. A novel dimensionality reduction method based on sparse representation is proposed for the design of multi-dimensional transfer function in direct volume rendering. It not only achieves the similar performance to the conventional methods, but also owns the capability to deal with the large data sets

Target detection, tracking, and localization using multi-spectral image fusion and RF Doppler differentials

It is critical for defense and security applications to have a high probability of detection and low false alarm rate while operating over a wide variety of conditions. Sensor fusion, which is the the process of combining data from two or more sensors, has been utilized to improve the performance of a system by exploiting the strengths of each sensor. This dissertation presents algorithms to fuse multi-sensor data that improves system performance by increasing detection rates, lowering false alarms, and improving track performance. Furthermore, this dissertation presents a framework for comparing algorithm error for image registration which is a critical pre-processing step for multi-spectral image fusion. First, I present an algorithm to improve detection and tracking performance for moving targets in a cluttered urban environment by fusing foreground maps from multi-spectral imagery. Most research in image fusion consider visible and long-wave infrared bands; I examine these bands along with near infrared and mid-wave infrared. To localize and track a particular target of interest, I present an algorithm to fuse output from the multi-spectral image tracker with a constellation of RF sensors measuring a specific cellular emanation. The fusion algorithm matches the Doppler differential from the RF sensors with the theoretical Doppler Differential of the video tracker output by selecting the sensor pair that minimizes the absolute difference or root-mean-square difference. Finally, a framework to quantify shift-estimation error for both area- and feature-based algorithms is presented. By exploiting synthetically generated visible and long-wave infrared imagery, error metrics are computed and compared for a number of area- and feature-based shift estimation algorithms. A number of key results are presented in this dissertation. The multi-spectral image tracker improves the location accuracy of the algorithm while improving the detection rate and lowering false alarms for most spectral bands. All 12 moving targets were tracked through the video sequence with only one lost track that was later recovered. Targets from the multi-spectral tracking algorithm were correctly associated with their corresponding cellular emanation for all targets at lower measurement uncertainty using the root-mean-square difference while also having a high confidence ratio for selecting the true target from background targets. For the area-based algorithms and the synthetic air-field image pair, the DFT and ECC algorithms produces sub-pixel shift-estimation error in regions such as shadows and high contrast painted line regions. The edge orientation feature descriptors increase the number of sub-field estimates while improving the shift-estimation error compared to the Lowe descriptor