Deep learning for unsupervised domain adaptation in medical imaging: Recent advancements and future perspectives

Deep learning has demonstrated remarkable performance across various tasks in medical imaging. However, these approaches primarily focus on supervised learning, assuming that the training and testing data are drawn from the same distribution. Unfortunately, this assumption may not always hold true in practice. To address these issues, unsupervised domain adaptation (UDA) techniques have been developed to transfer knowledge from a labeled domain to a related but unlabeled domain. In recent years, significant advancements have been made in UDA, resulting in a wide range of methodologies, including feature alignment, image translation, self-supervision, and disentangled representation methods, among others. In this paper, we provide a comprehensive literature review of recent deep UDA approaches in medical imaging from a technical perspective. Specifically, we categorize current UDA research in medical imaging into six groups and further divide them into finer subcategories based on the different tasks they perform. We also discuss the respective datasets used in the studies to assess the divergence between the different domains. Finally, we discuss emerging areas and provide insights and discussions on future research directions to conclude this survey.Comment: Under Revie

Deep learning based domain adaptation for mitochondria segmentation on EM volumes.

[EN] BACKGROUND AND OBJECTIVE: Accurate segmentation of electron microscopy (EM) volumes of the brain is essential to characterize neuronal structures at a cell or organelle level. While supervised deep learning methods have led to major breakthroughs in that direction during the past years, they usually require large amounts of annotated data to be trained, and perform poorly on other data acquired under similar experimental and imaging conditions. This is a problem known as domain adaptation, since models that learned from a sample distribution (or source domain) struggle to maintain their performance on samples extracted from a different distribution or target domain. In this work, we address the complex case of deep learning based domain adaptation for mitochondria segmentation across EM datasets from different tissues and species. METHODS: We present three unsupervised domain adaptation strategies to improve mitochondria segmentation in the target domain based on (1) state-of-the-art style transfer between images of both domains; (2) self-supervised learning to pre-train a model using unlabeled source and target images, and then fine-tune it only with the source labels; and (3) multi-task neural network architectures trained end-to-end with both labeled and unlabeled images. Additionally, to ensure good generalization in our models, we propose a new training stopping criterion based on morphological priors obtained exclusively in the source domain. The code and its documentation are publicly available at https://github.com/danifranco/EM_domain_adaptation. RESULTS: We carried out all possible cross-dataset experiments using three publicly available EM datasets. We evaluated our proposed strategies and those of others based on the mitochondria semantic labels predicted on the target datasets. CONCLUSIONS: The methods introduced here outperform the baseline methods and compare favorably to the state of the art. In the absence of validation labels, monitoring our proposed morphology-based metric is an intuitive and effective way to stop the training process and select in average optimal models.I. Arganda-Carreras would like to acknowledge the support of the 2020 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation. This work is supported in part by the University of the Basque Country UPV/EHU grant GIU19/027 and by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación, under grant PID2019-109820RB-I00, MCIN/AEI /10.13039/501100011033/, cofinanced by European Regional Development Fund (ERDF), “A way of making Europe.

Data efficient deep learning for medical image analysis: A survey

The rapid evolution of deep learning has significantly advanced the field of medical image analysis. However, despite these achievements, the further enhancement of deep learning models for medical image analysis faces a significant challenge due to the scarcity of large, well-annotated datasets. To address this issue, recent years have witnessed a growing emphasis on the development of data-efficient deep learning methods. This paper conducts a thorough review of data-efficient deep learning methods for medical image analysis. To this end, we categorize these methods based on the level of supervision they rely on, encompassing categories such as no supervision, inexact supervision, incomplete supervision, inaccurate supervision, and only limited supervision. We further divide these categories into finer subcategories. For example, we categorize inexact supervision into multiple instance learning and learning with weak annotations. Similarly, we categorize incomplete supervision into semi-supervised learning, active learning, and domain-adaptive learning and so on. Furthermore, we systematically summarize commonly used datasets for data efficient deep learning in medical image analysis and investigate future research directions to conclude this survey.Comment: Under Revie

Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

Transductive Transfer Learning for Domain Adaptation in Brain Magnetic Resonance Image Segmentation

Cervell; Imatge per ressonància magnètica; Aprenentatge transductiuCerebro; Imagen de resonancia magnética; Aprendizaje transductivoBrain; Magnetic resonance imaging; Transductive learningSegmentation of brain images from Magnetic Resonance Images (MRI) is an indispensable step in clinical practice. Morphological changes of sub-cortical brain structures and quantification of brain lesions are considered biomarkers of neurological and neurodegenerative disorders and used for diagnosis, treatment planning, and monitoring disease progression. In recent years, deep learning methods showed an outstanding performance in medical image segmentation. However, these methods suffer from generalisability problem due to inter-centre and inter-scanner variabilities of the MRI images. The main objective of the study is to develop an automated deep learning segmentation approach that is accurate and robust to the variabilities in scanner and acquisition protocols. In this paper, we propose a transductive transfer learning approach for domain adaptation to reduce the domain-shift effect in brain MRI segmentation. The transductive scenario assumes that there are sets of images from two different domains: (1) source—images with manually annotated labels; and (2) target—images without expert annotations. Then, the network is jointly optimised integrating both source and target images into the transductive training process to segment the regions of interest and to minimise the domain-shift effect. We proposed to use a histogram loss in the feature level to carry out the latter optimisation problem. In order to demonstrate the benefit of the proposed approach, the method has been tested in two different brain MRI image segmentation problems using multi-centre and multi-scanner databases for: (1) sub-cortical brain structure segmentation; and (2) white matter hyperintensities segmentation. The experiments showed that the segmentation performance of a pre-trained model could be significantly improved by up to 10%. For the first segmentation problem it was possible to achieve a maximum improvement from 0.680 to 0.799 in average Dice Similarity Coefficient (DSC) metric and for the second problem the average DSC improved from 0.504 to 0.602. Moreover, the improvements after domain adaptation were on par or showed better performance compared to the commonly used traditional unsupervised segmentation methods (FIRST and LST), also achieving faster execution time. Taking this into account, this work presents one more step toward the practical implementation of deep learning algorithms into the clinical routine.KK holds FI-DGR2017 grant from the Catalan Government with reference number 2017FI_B00372. This work has been supported by DPI2017-86696-R from the Ministerio de Ciencia y Tecnologia

Privacy Preserving Domain Adaptation for Semantic Segmentation of Medical Images

Convolutional neural networks (CNNs) have led to significant improvements in tasks involving semantic segmentation of images. CNNs are vulnerable in the area of biomedical image segmentation because of distributional gap between two source and target domains with different data modalities which leads to domain shift. Domain shift makes data annotations in new modalities necessary because models must be retrained from scratch. Unsupervised domain adaptation (UDA) is proposed to adapt a model to new modalities using solely unlabeled target domain data. Common UDA algorithms require access to data points in the source domain which may not be feasible in medical imaging due to privacy concerns. In this work, we develop an algorithm for UDA in a privacy-constrained setting, where the source domain data is inaccessible. Our idea is based on encoding the information from the source samples into a prototypical distribution that is used as an intermediate distribution for aligning the target domain distribution with the source domain distribution. We demonstrate the effectiveness of our algorithm by comparing it to state-of-the-art medical image semantic segmentation approaches on two medical image semantic segmentation datasets