Conference Proceedings at Publishing Cross-Roads

The potential intrinsic to electronic publishing provides conference conveners with the opportunity to position the papers presented to greater advantage of both authors and readers. Unfortunately, conference papers are being increasingly published in the most expensive vehicle, the formal peer-reviewed journal. This circumstance is counter-productive to the legitimate role of conference papers in scholarly communication. The experience at Caltech in electronically publishing the proceedings of an international conference shows that conference papers can be more effectively published online at significantly less cost thus increasing dissemination and acces

The relationship between ILL/document supply and journal subscriptions

Purpose: The purpose of this article is to provide insights into the relationship between ILL/ document supply and journal subscriptions and to assess recent trends in the ILL service. Design/methodology/Approach: This survey is based on data from the ILL service conducted over the five year period 2005-2009 through the Italian NILDE (Network for Inter-Library Document Exchange) network. Findings: This article bears out important previous findings that ILL is not used as a surrogate for journal subscriptions. This is supported by the analysis of a broad number of titles and over a wide time-range. On the contrary, analysis of data transactions, particularly of the most requested journals, can bring about positive effects on new title acquisitions and negotiations with publishers. This paper also shows, at least for Italy, an overall growth and vitality of ILL, in spite of the widespread availability of e-journals acquired through consortia purchasing. Originality/Value: An insight into the relationship between ILL and journal subscriptions in Italy, a country where few studies have been carried out, and none at all for such a large number of libraries and transactions

Friends of Musselman LIbrary Newsletter Spring 2008

Table of Contents: From the Director: Honor with Books Kick-Off (Robin Wagner, Brittany Bloam ’07, Jack Ryan, Robert Bohrer); Library Helps Information Literacy (Katherine Downton); Save the Date: Piano Trio; Library Lingo (Kathy D’Angelo); Federated Searching; Focus on Philanthropy: Rare American Bible Folios (Geoff Jackson ‘91); Phi Kappa Psi Papers (Reverend Fredrick Weiser ’57, Ned Brownley ’53); Rare Albumen Prints of the Gettysburg Battlefield; Gettysburg Semester (Allen Guelzo); 2 WWII Propaganda Posters; GettDigital: How It Is Done (Tina Gebhart); Hidden Talents (Neil Beach, Kathy Bradley, Kim Davidson, Julia Hendon, Suzy Miller, Janelle Wertzberger); Library Exhibits (Lindsay Treworgy ’08); LP Records (Tim Sestrick, Amy Ward); Study Break – Decorate Carts; Music at Musselman (Dr. F. William Sunderman Senior \u2719, Dr. F. William Sunderman Junior); Librarians in Vienna; Alumni Collectors( William C. Wright ‘61 and Ian Isherwood); Pat Hogan and Pat Boron; Warner Endowmen

A Proposed Solution to the Scholarly Communication Crisis

After reviewing the history and parameters of the scholarly communications crisis, particularly in regard to skyrocketing prices for journals in the natural sciences, the author reviews and rejects previously attempted solutions. He then employs the principles of game theory in proposing a new solution to the crisis

Artificial escape from XCI by DNA methylation editing of the CDKL5 gene.

A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here, we created an artificial escape by editing DNA methylation on the promoter of CDKL5, a gene causative for an infantile epilepsy, from the silenced X-chromosomal allele in human neuronal-like cells. We identify that a fusion of the catalytic domain of TET1 to dCas9 targeted to the CDKL5 promoter using three guide RNAs causes significant reactivation of the inactive allele in combination with removal of methyl groups from CpG dinucleotides. Strikingly, we demonstrate that co-expression of TET1 and a VP64 transactivator have a synergistic effect on the reactivation of the inactive allele to levels >60% of the active allele. We further used a multi-omics assessment to determine potential off-targets on the transcriptome and methylome. We find that synergistic delivery of dCas9 effectors is highly selective for the target site. Our findings further elucidate a causal role for reduced DNA methylation associated with escape from X chromosome inactivation. Understanding the epigenetics associated with escape from X chromosome inactivation has potential for those suffering from X-linked disorders

Library News and Notes

Newsletter of the Boston University Alumni Medical Librar

Lifecycle information for e-literature: full report from the LIFE project

This Report is a record of the LIFE Project. The Project has been run for one year and its aim is to deliver crucial information about the cost and management of digital material. This information should then in turn be able to be applied to any institution that has an interest in preserving and providing access to electronic collections. The Project is a joint venture between The British Library and UCL Library Services. The Project is funded by JISC under programme area (i) as listed in paragraph 16 of the JISC 4/04 circular- Institutional Management Support and Collaboration and as such has set requirements and outcomes which must be met and the Project has done its best to do so. Where the Project has been unable to answer specific questions, strong recommendations have been made for future Project work to do so. The outcomes of this Project are expected to be a practical set of guidelines and a framework within which costs can be applied to digital collections in order to answer the following questions: • What is the long term cost of preserving digital material; • Who is going to do it; • What are the long term costs for a library in HE/FE to partner with another institution to carry out long term archiving; • What are the comparative long-term costs of a paper and digital copy of the same publication; • At what point will there be sufficient confidence in the stability and maturity of digital preservation to switch from paper for publications available in parallel formats; • What are the relative risks of digital versus paper archiving. The Project has attempted to answer these questions by using a developing lifecycle methodology and three diverse collections of digital content. The LIFE Project team chose UCL e-journals, BL Web Archiving and the BL VDEP digital collections to provide a strong challenge to the methodology as well as to help reach the key Project aim of attributing long term cost to digital collections. The results from the Case Studies and the Project findings are both surprising and illuminating