A Synapse-Threshold Synergistic Learning Approach for Spiking Neural Networks

Spiking neural networks (SNNs) have demonstrated excellent capabilities in various intelligent scenarios. Most existing methods for training SNNs are based on the concept of synaptic plasticity; however, learning in the realistic brain also utilizes intrinsic non-synaptic mechanisms of neurons. The spike threshold of biological neurons is a critical intrinsic neuronal feature that exhibits rich dynamics on a millisecond timescale and has been proposed as an underlying mechanism that facilitates neural information processing. In this study, we develop a novel synergistic learning approach that simultaneously trains synaptic weights and spike thresholds in SNNs. SNNs trained with synapse-threshold synergistic learning (STL-SNNs) achieve significantly higher accuracies on various static and neuromorphic datasets than SNNs trained with two single-learning models of the synaptic learning (SL) and the threshold learning (TL). During training, the synergistic learning approach optimizes neural thresholds, providing the network with stable signal transmission via appropriate firing rates. Further analysis indicates that STL-SNNs are robust to noisy data and exhibit low energy consumption for deep network structures. Additionally, the performance of STL-SNN can be further improved by introducing a generalized joint decision framework (JDF). Overall, our findings indicate that biologically plausible synergies between synaptic and intrinsic non-synaptic mechanisms may provide a promising approach for developing highly efficient SNN learning methods.Comment: 13 pages, 9 figures, submitted for publicatio

Learning to process with spikes and to localise pulses

In the last few decades, deep learning with artificial neural networks (ANNs) has emerged as one of the most widely used techniques in tasks such as classification and regression, achieving competitive results and in some cases even surpassing human-level performance. Nonetheless, as ANN architectures are optimised towards empirical results and departed from their biological precursors, how exactly human brains process information using these short electrical pulses called spikes remains a mystery. Hence, in this thesis, we explore the problem of learning to process with spikes and to localise pulses. We first consider spiking neural networks (SNNs), a type of ANN that more closely mimic biological neural networks in that neurons communicate with one another using spikes. This unique architecture allows us to look into the role of heterogeneity in learning. Since it is conjectured that the information is encoded by the timing of spikes, we are particularly interested in the heterogeneity of time constants of neurons. We then trained SNNs for classification tasks on a range of visual and auditory neuromorphic datasets, which contain streams of events (spike times) instead of the conventional frame-based data, and show that the overall performance is improved by allowing the neurons to have different time constants, especially on tasks with richer temporal structure. We also find that the learned time constants are distributed similarly to those experimentally observed in some mammalian cells. Besides, we demonstrate that learning with heterogeneity improves robustness against hyperparameter mistuning. These results suggest that heterogeneity may be more than the byproduct of noisy processes and perhaps serves a key role in learning in changing environments, yet heterogeneity has been overlooked in basic artificial models. While neuromorphic datasets, which are often captured by neuromorphic devices that closely model the corresponding biological systems, have enabled us to explore the more biologically plausible SNNs, there still exists a gap in understanding how spike times encode information in actual biological neural networks like human brains, as such data is difficult to acquire due to the trade-off between the timing precision and the number of cells simultaneously recorded electrically. Instead, what we usually obtain is the low-rate discrete samples of trains of filtered spikes. Hence, in the second part of the thesis, we focus on a different type of problem involving pulses, that is to retrieve the precise pulse locations from these low-rate samples. We make use of the finite rate of innovation (FRI) sampling theory, which states that perfect reconstruction is possible for classes of continuous non-bandlimited signals that have a small number of free parameters. However, existing FRI methods break down under very noisy conditions due to the so-called subspace swap event. Thus, we present two novel model-based learning architectures: Deep Unfolded Projected Wirtinger Gradient Descent (Deep Unfolded PWGD) and FRI Encoder-Decoder Network (FRIED-Net). The former is based on the existing iterative denoising algorithm for subspace-based methods, while the latter models directly the relationship between the samples and the locations of the pulses using an autoencoder-like network. Using a stream of K Diracs as an example, we show that both algorithms are able to overcome the breakdown inherent in the existing subspace-based methods. Moreover, we extend our FRIED-Net framework beyond conventional FRI methods by considering when the shape is unknown. We show that the pulse shape can be learned using backpropagation. This coincides with the application of spike detection from real-world calcium imaging data, where we achieve competitive results. Finally, we explore beyond canonical FRI signals and demonstrate that FRIED-Net is able to reconstruct streams of pulses with different shapes.Open Acces

Machine Learning Methods for Image Analysis in Medical Applications, from Alzheimer\u27s Disease, Brain Tumors, to Assisted Living

Healthcare has progressed greatly nowadays owing to technological advances, where machine learning plays an important role in processing and analyzing a large amount of medical data. This thesis investigates four healthcare-related issues (Alzheimer\u27s disease detection, glioma classification, human fall detection, and obstacle avoidance in prosthetic vision), where the underlying methodologies are associated with machine learning and computer vision. For Alzheimer’s disease (AD) diagnosis, apart from symptoms of patients, Magnetic Resonance Images (MRIs) also play an important role. Inspired by the success of deep learning, a new multi-stream multi-scale Convolutional Neural Network (CNN) architecture is proposed for AD detection from MRIs, where AD features are characterized in both the tissue level and the scale level for improved feature learning. Good classification performance is obtained for AD/NC (normal control) classification with test accuracy 94.74%. In glioma subtype classification, biopsies are usually needed for determining different molecular-based glioma subtypes. We investigate non-invasive glioma subtype prediction from MRIs by using deep learning. A 2D multi-stream CNN architecture is used to learn the features of gliomas from multi-modal MRIs, where the training dataset is enlarged with synthetic brain MRIs generated by pairwise Generative Adversarial Networks (GANs). Test accuracy 88.82% has been achieved for IDH mutation (a molecular-based subtype) prediction. A new deep semi-supervised learning method is also proposed to tackle the problem of missing molecular-related labels in training datasets for improving the performance of glioma classification. In other two applications, we also address video-based human fall detection by using co-saliency-enhanced Recurrent Convolutional Networks (RCNs), as well as obstacle avoidance in prosthetic vision by characterizing obstacle-related video features using a Spiking Neural Network (SNN). These investigations can benefit future research, where artificial intelligence/deep learning may open a new way for real medical applications

Efficient Learning Machines

Computer scienc

Spatio-temporal human action detection and instance segmentation in videos

With an exponential growth in the number of video capturing devices and digital video content, automatic video understanding is now at the forefront of computer vision research. This thesis presents a series of models for automatic human action detection in videos and also addresses the space-time action instance segmentation problem. Both action detection and instance segmentation play vital roles in video understanding. Firstly, we propose a novel human action detection approach based on a frame-level deep feature representation combined with a two-pass dynamic programming approach. The method obtains a frame-level action representation by leveraging recent advances in deep learning based action recognition and object detection methods. To combine the the complementary appearance and motion cues, we introduce a new fusion technique which signicantly improves the detection performance. Further, we cast the temporal action detection as two energy optimisation problems which are solved using Viterbi algorithm. Exploiting a video-level representation further allows the network to learn the inter-frame temporal correspondence between action regions and it is bound to be a more optimal solution to the action detection problem than a frame-level representation. Secondly, we propose a novel deep network architecture which learns a video-level action representation by classifying and regressing 3D region proposals spanning two successive video frames. The proposed model is end-to-end trainable and can be jointly optimised for both proposal generation and action detection objectives in a single training step. We name our new network as \AMTnet" (Action Micro-Tube regression Network). We further extend the AMTnet model by incorporating optical ow features to encode motion patterns of actions. Finally, we address the problem of action instance segmentation in which multiple concurrent actions of the same class may be segmented out of an image sequence. By taking advantage of recent work on action foreground-background segmentation, we are able to associate each action tube with class-specic segmentations. We demonstrate the performance of our proposed models on challenging action detection benchmarks achieving new state-of-the-art results across the board and signicantly increasing detection speed at test time

Autonomously Reconfigurable Artificial Neural Network on a Chip

Artificial neural network (ANN), an established bio-inspired computing paradigm, has proved very effective in a variety of real-world problems and particularly useful for various emerging biomedical applications using specialized ANN hardware. Unfortunately, these ANN-based systems are increasingly vulnerable to both transient and permanent faults due to unrelenting advances in CMOS technology scaling, which sometimes can be catastrophic. The considerable resource and energy consumption and the lack of dynamic adaptability make conventional fault-tolerant techniques unsuitable for future portable medical solutions. Inspired by the self-healing and self-recovery mechanisms of human nervous system, this research seeks to address reliability issues of ANN-based hardware by proposing an Autonomously Reconfigurable Artificial Neural Network (ARANN) architectural framework. Leveraging the homogeneous structural characteristics of neural networks, ARANN is capable of adapting its structures and operations, both algorithmically and microarchitecturally, to react to unexpected neuron failures. Specifically, we propose three key techniques --- Distributed ANN, Decoupled Virtual-to-Physical Neuron Mapping, and Dual-Layer Synchronization --- to achieve cost-effective structural adaptation and ensure accurate system recovery. Moreover, an ARANN-enabled self-optimizing workflow is presented to adaptively explore a "Pareto-optimal" neural network structure for a given application, on the fly. Implemented and demonstrated on a Virtex-5 FPGA, ARANN can cover and adapt 93% chip area (neurons) with less than 1% chip overhead and O(n) reconfiguration latency. A detailed performance analysis has been completed based on various recovery scenarios

Robust and Efficient Activity Recognition from Videos

With technological advancement in embedded system design, powerful cameras have been embedded within smart phones, and wireless cameras can be easily deployed at street corners, traffic lights, big stadiums, train stations, etc. Besides, the growth of online media, surveillance, and mobile cameras have resulted in an explosion of videos being uploaded to social media sites such as Facebook and YouTube. The availability of such a vast volume of videos has attracted the computer vision community to conduct much research on human activity recognition since people are arguably the most interesting subjects of such videos. Automatic human activity recognition allows engineers and computer scientists to design smarter surveillance systems, semantically aware video indexes and also more natural human-computer interfaces. Despite the explosion of video data, the ability to automatically recognize and understand human activities is still rather limited. This is primarily due to multiple challenges inherent to the recognition task, namely large variability in human execution styles, the complexity of the visual stimuli in terms of camera motion, background clutter, viewpoint changes, etc., and the number of activities that can be recognized. In addition, the ability to predict future actions of objects based on past observed video frames is very useful. Therefore, in this thesis, we explore four designs to solve the problems we discussed earlier, namely (1) A semantics-based deep learning model, namely SBGAR, is proposed to do group activity recognition. This model achieves higher accuracy and efficiency than existing group activity recognition methods. (2) Despite its high accuracy, SBGAR has some limitations, namely (i) it requires a large dataset with caption information, (ii) activity recognition model is independent of the caption generation model and hence SBGAR may not perform well in some cases. To remove such limitations, we design ReHAR, a robust and efficient human activity recognition scheme. ReHAR can be used to recognize both single-person activities and group activities. (3) In many application scenarios, merely knowing what the moving agents are doing is not sufficient. It also requires predictions of future trajectories of moving agents. Thus, we propose GRIP, a graph-based interaction-aware motion intent prediction scheme. The scheme uses a graph to represent the relationships between two objects, e.g., human joints or traffic agents, and predict the motion intents of all observed objects simultaneously. (4) Action recognition and trajectory prediction schemes are typically deployed in resource-constrained devices. Thus, any technique that can accelerate the computation speed of our schemes is important. Hence, we propose a novel deep learning model decomposition method called DAC that is capable of factorizing an ordinary convolutional layer into two layers with much fewer parameters. DAC computes the corresponding weights for the newly generated layers directly from the weights of the original convolutional layer. Thus, no training (or fine-tuning) or any data is needed

Action selection in the striatum: Implications for Huntington's disease

Although the basal ganglia have been widely studied and implicated in signal processing and action selection, little information is known about the active role that the striatal microcircuit plays in action selection in the basal ganglia-cortical-thalamic loops. To address this knowledge gap we use a large scale three dimensional spiking model of the striatum, combined with a rate coded model of the basal ganglia-cortical-thalamic loop, to asses the computational role the striatum plays in action selection. We identify robust transient phenomena generated by the striatal microcircuit, which temporarily enhances the difference between two competing cortical inputs. We show that this transient is sufficient to modulate decision making in the basal ganglia-thalamo-cortical circuit. We also find that the transient selection originates from a novel adaptation effect in single striatal projection neurons, which is amenable to experimental testing. Finally, we compared transient selection with models implementing classical steady-state selection. We challenged both forms of model to account for recent reports of paradoxically enhanced response selection in Huntington's disease patients. We found that steady-state selection was uniformly impaired under all simulated Huntington's conditions, but transient selection was enhanced given a sufficient Huntington's-like increase in NMDA receptor sensitivity. I propose a mechanistic underpinning to a novel neural compensatory mechanism, responsible for improved cognition in severe neuro-degeneration. Thus, our models provide an intriguing hypothesis for the mechanisms underlying the paradoxical cognitive improvements in manifest Huntington's patients, which is consistent with recent behavioural data