23,820 research outputs found
Pemilihan kerjaya di kalangan pelajar aliran perdagangan sekolah menengah teknik : satu kajian kes
This research is a survey to determine the career chosen of form four student
in commerce streams. The important aspect of the career chosen has been divided
into three, first is information about career, type of career and factor that most
influence students in choosing a career. The study was conducted at Sekolah
Menengah Teknik Kajang, Selangor Darul Ehsan. Thirty six form four students was
chosen by using non-random sampling purpose method as respondent. All
information was gather by using questionnaire. Data collected has been analyzed in
form of frequency, percentage and mean. Results are performed in table and graph.
The finding show that information about career have been improved in students
career chosen and mass media is the main factor influencing students in choosing
their career
Privacy in the Genomic Era
Genome sequencing technology has advanced at a rapid pace and it is now
possible to generate highly-detailed genotypes inexpensively. The collection
and analysis of such data has the potential to support various applications,
including personalized medical services. While the benefits of the genomics
revolution are trumpeted by the biomedical community, the increased
availability of such data has major implications for personal privacy; notably
because the genome has certain essential features, which include (but are not
limited to) (i) an association with traits and certain diseases, (ii)
identification capability (e.g., forensics), and (iii) revelation of family
relationships. Moreover, direct-to-consumer DNA testing increases the
likelihood that genome data will be made available in less regulated
environments, such as the Internet and for-profit companies. The problem of
genome data privacy thus resides at the crossroads of computer science,
medicine, and public policy. While the computer scientists have addressed data
privacy for various data types, there has been less attention dedicated to
genomic data. Thus, the goal of this paper is to provide a systematization of
knowledge for the computer science community. In doing so, we address some of
the (sometimes erroneous) beliefs of this field and we report on a survey we
conducted about genome data privacy with biomedical specialists. Then, after
characterizing the genome privacy problem, we review the state-of-the-art
regarding privacy attacks on genomic data and strategies for mitigating such
attacks, as well as contextualizing these attacks from the perspective of
medicine and public policy. This paper concludes with an enumeration of the
challenges for genome data privacy and presents a framework to systematize the
analysis of threats and the design of countermeasures as the field moves
forward
How will the Internet of Things enable Augmented Personalized Health?
Internet-of-Things (IoT) is profoundly redefining the way we create, consume,
and share information. Health aficionados and citizens are increasingly using
IoT technologies to track their sleep, food intake, activity, vital body
signals, and other physiological observations. This is complemented by IoT
systems that continuously collect health-related data from the environment and
inside the living quarters. Together, these have created an opportunity for a
new generation of healthcare solutions. However, interpreting data to
understand an individual's health is challenging. It is usually necessary to
look at that individual's clinical record and behavioral information, as well
as social and environmental information affecting that individual. Interpreting
how well a patient is doing also requires looking at his adherence to
respective health objectives, application of relevant clinical knowledge and
the desired outcomes.
We resort to the vision of Augmented Personalized Healthcare (APH) to exploit
the extensive variety of relevant data and medical knowledge using Artificial
Intelligence (AI) techniques to extend and enhance human health to presents
various stages of augmented health management strategies: self-monitoring,
self-appraisal, self-management, intervention, and disease progress tracking
and prediction. kHealth technology, a specific incarnation of APH, and its
application to Asthma and other diseases are used to provide illustrations and
discuss alternatives for technology-assisted health management. Several
prominent efforts involving IoT and patient-generated health data (PGHD) with
respect converting multimodal data into actionable information (big data to
smart data) are also identified. Roles of three components in an evidence-based
semantic perception approach- Contextualization, Abstraction, and
Personalization are discussed
Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine
Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study. Furthermore, the demand for logistics, instrumentations, and computational resources for metabolic phenotyping studies has far exceeded our expectations. In this conceptual review, we will cover inclusive barriers of a metabolomics-based clinical study and suggest potential solutions in the hope of enhancing study robustness, usability, and transferability. The importance of quality assurance and quality control procedures is discussed, followed by a practical rule containing five phases, including two additional "pre-pre-" and "post-post-" analytical steps. Besides, we will elucidate the potential involvement of machine learning and demonstrate that the need for automated data mining algorithms to improve the quality of future research is undeniable. Consequently, we propose a comprehensive metabolomics framework, along with an appropriate checklist refined from current guidelines and our previously published assessment, in the attempt to accurately translate achievements in metabolomics into clinical and epidemiological research. Furthermore, the integration of multifaceted multi-omics approaches with metabolomics as the pillar member is in urgent need. When combining with other social or nutritional factors, we can gather complete omics profiles for a particular disease. Our discussion reflects the current obstacles and potential solutions toward the progressing trend of utilizing metabolomics in clinical research to create the next-generation healthcare system.11Ysciescopu
Clinical proteomics for precision medicine: the bladder cancer case
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches. Proteomics attract high interest, as proteins reflect a “real-time” dynamic molecular phenotype. Focusing on proteomics applications for personalized medicine, a literature search was conducted to cover: a) disease prevention, b) monitoring/ prediction of treatment response, c) stratification to guide intervention and d) identification of drug targets. The review indicates the potential of proteomics for personalized medicine by also highlighting multiple challenges to be addressed prior to actual implementation. In oncology, particularly bladder cancer, application of precision medicine appears especially promising. The high heterogeneity and recurrence rates together with the limited treatment options, suggests that earlier and more efficient intervention, continuous monitoring and the development of alternative therapies could be accomplished by applying proteomics-guided personalized approaches. This notion is backed by studies presenting biomarkers that are of value in patient stratification and prognosis, and by recent studies demonstrating the identification of promising therapeutic targets. Herein, we aim to present an approach whereby combining the knowledge on biomarkers and therapeutic targets in bladder cancer could serve as basis towards proteomics- guided personalized patient management
- …