Model validation for a noninvasive arterial stenosis detection problem

Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use both one-dimensional pressure and shear wave experimental data from novel acoustic phantoms to validate corresponding viscoelastic mathematical models, which were developed in a concept paper [8] and refined herein. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.The National Institute of Allergy and Infectious Diseases, the Air Force Office of Scientific Research, the Deopartment of Education and the Engineering and Physical Sciences Research Council (EPSRC)

High-order space-time finite element schemes for acoustic and viscodynamic wave equations with temporal decoupling

Copyright @ 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.We revisit a method originally introduced by Werder et al. (in Comput. Methods Appl. Mech. Engrg., 190:6685–6708, 2001) for temporally discontinuous Galerkin FEMs applied to a parabolic partial differential equation. In that approach, block systems arise because of the coupling of the spatial systems through inner products of the temporal basis functions. If the spatial finite element space is of dimension D and polynomials of degree r are used in time, the block system has dimension (r + 1)D and is usually regarded as being too large when r > 1. Werder et al. found that the space-time coupling matrices are diagonalizable over inline image for r ⩽100, and this means that the time-coupled computations within a time step can actually be decoupled. By using either continuous Galerkin or spectral element methods in space, we apply this DG-in-time methodology, for the first time, to second-order wave equations including elastodynamics with and without Kelvin–Voigt and Maxwell–Zener viscoelasticity. An example set of numerical results is given to demonstrate the favourable effect on error and computational work of the moderately high-order (up to degree 7) temporal and spatio-temporal approximations, and we also touch on an application of this method to an ambitious problem related to the diagnosis of coronary artery disease

Material parameter estimation and hypothesis testing on a 1D viscoelastic stenosis model: Methodology

This is the post-print version of the final published paper that is available from the link below. Copyright @ 2013 Walter de Gruyter GmbH.Non-invasive detection, localization and characterization of an arterial stenosis (a blockage or partial blockage in the artery) continues to be an important problem in medicine. Partial blockage stenoses are known to generate disturbances in blood flow which generate shear waves in the chest cavity. We examine a one-dimensional viscoelastic model that incorporates Kelvin–Voigt damping and internal variables, and develop a proof-of-concept methodology using simulated data. We first develop an estimation procedure for the material parameters. We use this procedure to determine confidence intervals for the estimated parameters, which indicates the efficacy of finding parameter estimates in practice. Confidence intervals are computed using asymptotic error theory as well as bootstrapping. We then develop a model comparison test to be used in determining if a particular data set came from a low input amplitude or a high input amplitude; this we anticipate will aid in determining when stenosis is present. These two thrusts together will serve as the methodological basis for our continuing analysis using experimental data currently being collected.National Institute of Allergy and Infectious Diseases, Air Force Office of Scientific Research, Department of Education, and Engineering and Physical Sciences Research Council

Numerical Simulations of Bubble Dynamics Near Viscoelastic Media

Cavitation-induced damage occurs in a wide range of applications, including in naval hydrodynamics, medicine, and the Spallation Neutron Source. Local transient pressure decreases in liquid flow may give rise to explosive bubble growth and violent collapse, with shock waves produced at collapse interacting with neighboring solids. Although the mechanisms of erosion to hard, metallic solids can be predicted in relatively simple geometries, damage to soft materials (e.g., elastomeric coatings, soft tissue) or in confined geometries is less well understood. In such problems, the constitutive models describing the medium are non-trivial and include effects such as (nonlinear) elasticity, history (relaxation effects) and viscosity. As a result, the influence of the shock on the material and the response of the material to the shock are poorly understood. To gain fundamental insights into cavitation-induced damage to both soft objects and rigid materials, we develop a novel Eulerian approach for numerical simulations of wave propagation in heterogeneous viscoelastic media. We extend the five-equations multiphase, interface-capturing model, based on the idea that all the materials (gases, liquids, solids) obey the same equation of state with spatially varying properties, to incorporate the desired constitutive relation. We consider problems in which the deformations are small, such that the substances can be described by linear viscoelastic constitutive relations. One difficulty is the calculation of strains in an Eulerian framework, which we address by using a hypoelastic model in which an objective time derivative (Lie derivative) of the constitutive relation is taken to evolve strain rates. The resulting numerical framework is a solution-adaptive, high-order interface-capturing approach for compressible, multiphase flows involving linear viscoelasticity at all speeds. We then utilize this numerical framework to gain fundamental insights into cavitation damage (i) in a confined geometry, (ii) in shock wave lithotripsy, and (iii) to rigid objects covered by an elastomeric coating. We examine the maximum stresses, pressures, and temperatures along/in rigid/compliant objects. We quantify the effect of confinement on an inertially collapsing bubble and determine the appropriate scaling governing the maximum pressures can predicted on the surfaces. We investigate the stresses produced to a model kidney stone due to a shock wave by examining the amplification of tensile stresses in the stone when a gas bubble is present. The impact loads on a polymeric coating relevant to naval engineering applications by shock-induced bubble collapse indicate how pitting and coating material ejection may take place by repeated cavitation events near the surface.PHDMechanical EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/147536/1/mrdz_1.pd

Quantitative inverse problem in visco-acoustic media under attenuation model uncertainty

We consider the inverse problem of quantitative reconstruction of properties (e.g., bulk modulus, density) of visco-acoustic materials based on measurements of responding waves after stimulation of the medium. Numerical reconstruction is performed by an iterative minimization algorithm. Firstly, we investigate the robustness of the algorithm with respect to attenuation model uncertainty, that is, when different attenuation models are used to simulate synthetic observation data and for the inversion, respectively. Secondly, to handle data-sets with multiple reflections generated by wall boundaries around the domain, we perform inversion using complex frequencies, and show that it offers a robust framework that alleviates the difficulties of multiple reflections. To illustrate the efficiency of the algorithm, we perform numerical simulations of ultrasound imaging experiments to reconstruct a synthetic breast sample that contains an inclusion of high-contrast properties. We perform experiments in two and three dimensions, where the latter also serves to demonstrate the numerical feasibility in a large-scale configuration.Comment: 30 pages, 13 figure

Kelvin–Voigt Parameters Reconstruction of Cervical Tissue-Mimicking Phantoms Using Torsional Wave Elastography

The reconstruction of viscous properties of soft tissues, and more specifically, of cervical tissue is a challenging problem. In this paper, a new method is proposed to reconstruct the viscoelastic parameters of cervical tissue-mimicking phantoms by a Torsional Wave Elastography (TWE) technique. The reconstruction method, based on a Probabilistic Inverse Problem (PIP) approach, is presented and experimentally validated against Shear Wave Elastography (SWE). The anatomy of the cervical tissue has been mimicked by means of a two-layer gelatine phantom that simulates the epithelial and connective layers. Five ad hoc oil-in-gelatine phantoms were fabricated at different proportion to test the new reconstruction technique. The PIP approach was used for reconstructing the Kelvin-Voigt (KV) viscoelastic parameters by comparing the measurements obtained from the TWE technique with the synthetic signals from a Finite Difference Time Domain (FDTD) KV wave propagation model. Additionally, SWE tests were realized in order to characterize the viscoelastic properties of each batch of gelatine. Finally, validation was carried out by comparing the KV parameters inferred from the PIP with those reconstructed from the shear wave dispersion curve obtained from the SWE measurements. In order to test the degree of agreement between both techniques, a Student’s T-test and a Pearson’s correlation study were performed. The results indicate that the proposed method is able to reconstruct the KV viscoelastic properties of the cervical tissue, for both the epithelial and connective layers, as well as the thickness of the first layer with acceptable accuracy.This research was supported by the Ministry of Education, DPI2017-83859-R, DPI2014-51870-R, and UNGR15-CE-3664, Ministry of Health DTS15/00093, and Junta de Andalucía PI16/00339, PI-0107-2017, and PIN-0030-2017 projects

Wave Propagation in a Fractional Viscoelastic Tissue Model: Application to Transluminal Procedures

In this article, a wave propagation model is presented as the first step in the development of a new type of transluminal procedure for performing elastography. Elastography is a medical imaging modality for mapping the elastic properties of soft tissue. The wave propagation model is based on a Kelvin Voigt Fractional Derivative (KVFD) viscoelastic wave equation, and is numerically solved using a Finite Difference Time Domain (FDTD) method. Fractional rheological models, such as the KVFD, are particularly well suited to model the viscoelastic response of soft tissue in elastography. The transluminal procedure is based on the transmission and detection of shear waves through the luminal wall. Shear waves travelling through the tissue are perturbed after encountering areas of altered elasticity. These perturbations carry information of medical interest that can be extracted by solving the inverse problem. Scattering from prostate tumours is used as an example application to test the model. In silico results demonstrate that shear waves are satisfactorily transmitted through the luminal wall and that echoes, coming from reflected energy at the edges of an area of altered elasticity, which are feasibly detectable by using the transluminal approach. The model here presented provides a useful tool to establish the feasibility of transluminal procedures based on wave propagation and its interaction with the mechanical properties of the tissue outside the lumen.University College London, United KingdomTalentia scholarship (grant C2012H-75146405T-1) from the regional government of Andalusia, Spainthe Ministry of Education and Science, Spain, grants DPI2017-83859-R, EQC2018-004508-P and UNGR15-CE3664Andalusia, Spain, grants SOMM17/6109/UGR, B-TEP-026-UGR18, IE2017-5537 and P18-RT-165

Numerical modeling of transient two-dimensional viscoelastic waves

This paper deals with the numerical modeling of transient mechanical waves in linear viscoelastic solids. Dissipation mechanisms are described using the generalized Zener model. No time convolutions are required thanks to the introduction of memory variables that satisfy local-in-time differential equations. By appropriately choosing the relaxation parameters, it is possible to accurately describe a large range of materials, such as solids with constant quality factors. The evolution equations satisfied by the velocity, the stress, and the memory variables are written in the form of a first-order system of PDEs with a source term. This system is solved by splitting it into two parts: the propagative part is discretized explicitly, using a fourth-order ADER scheme on a Cartesian grid, and the diffusive part is then solved exactly. Jump conditions along the interfaces are discretized by applying an immersed interface method. Numerical experiments of wave propagation in viscoelastic and fluid media show the efficiency of this numerical modeling for dealing with challenging problems, such as multiple scattering configurations

Wave propagation in a fractional viscoelastic tissue model: Application to transluminal procedures

In this article, a wave propagation model is presented as the first step in the development of a new type of transluminal procedure for performing elastography. Elastography is a medical imaging modality for mapping the elastic properties of soft tissue. The wave propagation model is based on a Kelvin Voigt Fractional Derivative (KVFD) viscoelastic wave equation, and is numerically solved using a Finite Difference Time Domain (FDTD) method. Fractional rheological models, such as the KVFD, are particularly well suited to model the viscoelastic response of soft tissue in elastography. The transluminal procedure is based on the transmission and detection of shear waves through the luminal wall. Shear waves travelling through the tissue are perturbed after encountering areas of altered elasticity. These perturbations carry information of medical interest that can be extracted by solving the inverse problem. Scattering from prostate tumours is used as an example application to test the model. In silico results demonstrate that shear waves are satisfactorily transmitted through the luminal wall and that echoes, coming from reflected energy at the edges of an area of altered elasticity, which are feasibly detectable by using the transluminal approach. The model here presented provides a useful tool to establish the feasibility of transluminal procedures based on wave propagation and its interaction with the mechanical properties of the tissue outside the lumen