Zifazah: A Scientific Visualization Language for Tensor Field Visualizations

This thesis presents the design and prototype implementation of a scientific visualization language called Zifazah for composing and exploring 3D visualizations of diffusion tensor magnetic resonance imaging (DT-MRI or DTI) data. Unlike existing tools allowing flexible customization of data visualizations that are programmer-oriented, Zifazah focuses on domain scientists as end users in order to enable them to freely compose visualizations of their scientific data set. Verbal descriptions of end users about how they would build and explore DTI visualizations are analyzed to collect syntax, semantics, and control structures of the language. Zifazah makes use of the initial set of lexical terms and semantical patterns to provide a declarative language in the spirit of intuitive syntax and usage. Along with sample scripts representative of the main language design features, some new DTI visualizations created by end users using the novel language have also been presented

Visual Exploration And Information Analytics Of High-Dimensional Medical Images

Data visualization has transformed how we analyze increasingly large and complex data sets. Advanced visual tools logically represent data in a way that communicates the most important information inherent within it and culminate the analysis with an insightful conclusion. Automated analysis disciplines - such as data mining, machine learning, and statistics - have traditionally been the most dominant fields for data analysis. It has been complemented with a near-ubiquitous adoption of specialized hardware and software environments that handle the storage, retrieval, and pre- and postprocessing of digital data. The addition of interactive visualization tools allows an active human participant in the model creation process. The advantage is a data-driven approach where the constraints and assumptions of the model can be explored and chosen based on human insight and confirmed on demand by the analytic system. This translates to a better understanding of data and a more effective knowledge discovery. This trend has become very popular across various domains, not limited to machine learning, simulation, computer vision, genetics, stock market, data mining, and geography. In this dissertation, we highlight the role of visualization within the context of medical image analysis in the field of neuroimaging. The analysis of brain images has uncovered amazing traits about its underlying dynamics. Multiple image modalities capture qualitatively different internal brain mechanisms and abstract it within the information space of that modality. Computational studies based on these modalities help correlate the high-level brain function measurements with abnormal human behavior. These functional maps are easily projected in the physical space through accurate 3-D brain reconstructions and visualized in excellent detail from different anatomical vantage points. Statistical models built for comparative analysis across subject groups test for significant variance within the features and localize abnormal behaviors contextualizing the high-level brain activity. Currently, the task of identifying the features is based on empirical evidence, and preparing data for testing is time-consuming. Correlations among features are usually ignored due to lack of insight. With a multitude of features available and with new emerging modalities appearing, the process of identifying the salient features and their interdependencies becomes more difficult to perceive. This limits the analysis only to certain discernible features, thus limiting human judgments regarding the most important process that governs the symptom and hinders prediction. These shortcomings can be addressed using an analytical system that leverages data-driven techniques for guiding the user toward discovering relevant hypotheses. The research contributions within this dissertation encompass multidisciplinary fields of study not limited to geometry processing, computer vision, and 3-D visualization. However, the principal achievement of this research is the design and development of an interactive system for multimodality integration of medical images. The research proceeds in various stages, which are important to reach the desired goal. The different stages are briefly described as follows: First, we develop a rigorous geometry computation framework for brain surface matching. The brain is a highly convoluted structure of closed topology. Surface parameterization explicitly captures the non-Euclidean geometry of the cortical surface and helps derive a more accurate registration of brain surfaces. We describe a technique based on conformal parameterization that creates a bijective mapping to the canonical domain, where surface operations can be performed with improved efficiency and feasibility. Subdividing the brain into a finite set of anatomical elements provides the structural basis for a categorical division of anatomical view points and a spatial context for statistical analysis. We present statistically significant results of our analysis into functional and morphological features for a variety of brain disorders. Second, we design and develop an intelligent and interactive system for visual analysis of brain disorders by utilizing the complete feature space across all modalities. Each subdivided anatomical unit is specialized by a vector of features that overlap within that element. The analytical framework provides the necessary interactivity for exploration of salient features and discovering relevant hypotheses. It provides visualization tools for confirming model results and an easy-to-use interface for manipulating parameters for feature selection and filtering. It provides coordinated display views for visualizing multiple features across multiple subject groups, visual representations for highlighting interdependencies and correlations between features, and an efficient data-management solution for maintaining provenance and issuing formal data queries to the back end

Scientific Workflow Integration For Services Computing

In recent years, significant scientific advances are increasingly achieved through complex scientific processes. As the exponential growth in computing technologies and scientific data, a scientific workflow may comprise a large number of heterogeneous scientific services and applications, provided by different organizations. These services, applications, and their associated data are usually distributed across heterogeneous computing environments. The integration and management of such scientific workflows are pushing the limits of current workflow technology. This dissertation presents an integrated solution to composing, scheduling, executing and developing scientific workflows and scientific workflow management systems. To provide a foundation for workflow composition, scheduling, execution and management, we propose the first reference architecture for scientific workflow management systems. The reference architecture not only provides a high-level organization of subsystems and their interactions in a workflow system, but also provides a basis for comparison between different systems and a guidance for the architectural design of an SWFMS in a specific scientific domain. To integrate heterogeneous services and applications and enable them composed to workflows, we propose a task template model which not only provides an appropriate abstraction of heterogeneous services and applications, but also encapsulates the composition and mapping of shims and functional task components within a task interface. Our proposed task specification language (TSL) not only integrates heterogeneous services and applications into uniform workflow tasks, but also provides a solution to address both TYPE-I and TYPE-II shimming problems in composing scientific workflows. To schedule scientific workflows in emerging services computing environments, we propose two workflow scheduling algorithms, the SHEFT algorithm and the SCPOR algorithm, to prioritize tasks in a workflow, map tasks onto suitable resources and order the execution of tasks on the assigned resources, so that the workflow makespan can be minimized. Our extensive experiments have shown that our proposed algorithms not only outperform other algorithms for large-scale, data-intensive and compute intensive workflows, but also allow the assigned resources elastically change on demand of the size of workflows. To execute workflows on distributed computing environments, we propose a task run model to model the run-time behaviors of tasks. The proposed task run description language (TRDL) enables the execution of task instances constructed from heterogeneous services and applications. We also develop an SOA based task management subsystem to manage all task templates, task instances and task runs for the invocation and execution of various heterogeneous task components. Finally, our developed SOA based workflow management system, the VIEW system, and a VIEW based workflow application system, the FiberFlow system, validate our architectures, models, languages, and algorithms

Designing customizable end user applications using semantic technologies to improve information management

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, June 2006."May 2006."Includes bibliographical references (leaves 152-155).Personalization capabilities in computer applications attempt to better meet the needs of individuals. The more traditional and widespread paradigm in application design is that the user should adapt to the available application. This requires that the individual user's task be sliced and molded to fit the dimensions offered by an inflexible, monolithic application. It is desirable to have an application that can be shaped to fit each individual user's dynamic needs. However, it is important that this is done in an intuitive and unobtrusive way. In this thesis, we design and evaluate a personalizable application developed to aid life science researchers in their work. We designed the application in Haystack, a platform for developing semantic applications and user interfaces. The application gave the user flexibility in personalizing the way in which information is organized and displayed, while giving users access to the tools necessary to perform their tasks. We selected researchers as the user group to focus on because of the inherent necessity in their work for originality and dynamic adaptation. Life sciences research was chosen as the domain due to its potential to benefit from the application of semantic technologies. We tested how users reacted and adapted to this application by conducting a formal user study.by Sumudu Weerakoon Watugala.M.Eng

3D-in-2D Displays for ATC.

This paper reports on the efforts and accomplishments of the 3D-in-2D Displays for ATC project at the end of Year 1. We describe the invention of 10 novel 3D/2D visualisations that were mostly implemented in the Augmented Reality ARToolkit. These prototype implementations of visualisation and interaction elements can be viewed on the accompanying video. We have identified six candidate design concepts which we will further research and develop. These designs correspond with the early feasibility studies stage of maturity as defined by the NASA Technology Readiness Level framework. We developed the Combination Display Framework from a review of the literature, and used it for analysing display designs in terms of display technique used and how they are combined. The insights we gained from this framework then guided our inventions and the human-centered innovation process we use to iteratively invent. Our designs are based on an understanding of user work practices. We also developed a simple ATC simulator that we used for rapid experimentation and evaluation of design ideas. We expect that if this project continues, the effort in Year 2 and 3 will be focus on maturing the concepts and employment in a operational laboratory settings