Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Multiobjective strategies for New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Genetic algorithm based design optimisation for permanent magnet synchronous motors

This research work presents a new and efficient design methodology for the specification, development and manufacture of permanent magnet synchronous motors (PMSMs). In this paper a genetic algorithm based design optimisation technique for PMSMs is presented in which the multicriteria considered in the optimisation are the electromagnetic performance, the thermal performance and the material cost. Models have been developed for each criterion in order to calculate the objective vector. A software tool called PMSM Analyser was developed to assist the motor design methodology. The optimisation algorithms and the electromagnetic, thermal and cost models were integrated and interfaced using this software. The programme is demonstrated for the design of a 12 slot 10 pole PMSM. The design parameter vector contains stator bore diameter, stator tooth thickness and stator back iron thickness. For the base design the outer diameter of the stator is 180mm and the stack length of the motor is 90mm. The base design refers to the design before optimisation and the optimal design refers to the design with optimised dimensions. The optimisation programme predicts significant improvements over the baseline design and experimental results are presented which indicate good agreement with the predictions of the programme. The new approach has been used successfully in the development and design of a PMSM with a stall torque of 125Nm, rated torque of 75Nm at 1500r/min and output power of 12kW. The strengths of the design methodology are summarised with the genetic algorithm optimisation, innovative multi-objective handling and design models for the various disciplines of PMSM development

Improved sampling of the pareto-front in multiobjective genetic optimizations by steady-state evolution: a Pareto converging genetic algorithm

Previous work on multiobjective genetic algorithms has been focused on preventing genetic drift and the issue of convergence has been given little attention. In this paper, we present a simple steady-state strategy, Pareto Converging Genetic Algorithm (PCGA), which naturally samples the solution space and ensures population advancement towards the Pareto-front. PCGA eliminates the need for sharing/niching and thus minimizes heuristically chosen parameters and procedures. A systematic approach based on histograms of rank is introduced for assessing convergence to the Pareto-front, which, by definition, is unknown in most real search problems. We argue that there is always a certain inheritance of genetic material belonging to a population, and there is unlikely to be any significant gain beyond some point; a stopping criterion where terminating the computation is suggested. For further encouraging diversity and competition, a nonmigrating island model may optionally be used; this approach is particularly suited to many difficult (real-world) problems, which have a tendency to get stuck at (unknown) local minima. Results on three benchmark problems are presented and compared with those of earlier approaches. PCGA is found to produce diverse sampling of the Pareto-front without niching and with significantly less computational effort

A software framework based on a conceptual unified model for evolutionary multiobjective optimization: ParadisEO-MOEO

International audienceThis paper presents a general-purpose software framework dedicated to the design and the implementation of evolutionary multiobjective optimization techniques: ParadisEO-MOEO. A concise overview of evolutionary algorithms for multiobjective optimization is given. A substantial number of methods has been proposed so far, and an attempt of conceptually unifying existing approaches is presented here. Based on a fine-grained decomposition and following the main issues of fitness assignment, diversity preservation and elitism, a conceptual model is proposed and is validated by regarding a number of state-of-the-art algorithms as simple variants of the same structure. This model is then incorporated into the ParadisEO-MOEO software framework. This framework has proven its validity and high flexibility by enabling the resolution of many academic, real-world and hard multiobjective optimization problems

A multi-objective approach for the segmentation issue

Special Issue: Multi-objective metaheuristics for multi-disciplinary engineering applicationsThis work presents and formalizes an explicit multi-objective evolutionary approach for the segmentation issue according to Piecewise Linear Representation, which consists in the approximation of a given digital curve by a set of linear models minimizing the representation error and the number of such models required. Available techniques are focused on the minimization of the quality of the obtained approximation, being the cost of that approximation considered, in general, only for certain comparison purposes. The multi-objective nature of the problem is analysed and its treatment in available works reviewed, presenting an a posteriori approach based on an evolutionary algorithm. Three representative curves are included in the data set, comparing the proposed technique to nine different techniques. The performance of the presented approach is tested according to single and multiobjective perspectives. The statistical tests carried out show that the experimental results are, in general, significantly better than available approaches from both perspectives.This work was supported in part by Projects CICYT TIN2008-06742-C02-02/TSI, CICYT TEC2008-06732-C02-02/TEC, CAM CONTEXTS (S2009/TIC-1485) and DPS2008-07029-C02-02.Publicad

ParadisEO-MOEO: A Software Framework for Evolutionary Multi-Objective Optimization

This chapter presents ParadisEO-MOEO, a white-box object-oriented software framework dedicated to the flexible design of metaheuristics for multi-objective optimization. This paradigm-free software proposes a unified view for major evolutionary multi-objective metaheuristics. It embeds some features and techniques for multi-objective resolution and aims to provide a set of classes allowing to ease and speed up the development of computationally efficient programs. It is based on a clear conceptual distinction between the solution methods and the problems they are intended to solve. This separation confers a maximum design and code reuse. This general-purpose framework provides a broad range of fitness assignment strategies, the most common diversity preservation mechanisms, some elitistrelated features as well as statistical tools. Furthermore, a number of state-of-the-art search methods, including NSGA-II, SPEA2 and IBEA, have been implemented in a user-friendly way, based on the fine-grained ParadisEO-MOEO components

Task scheduling for FMS based on genetic algorithm

A Flexible Manufacturing System (FMS) consisting of p automated guided vehicles (AGV\u27s), m workstations and n tasks is studied. The main problem investigated in this thesis is to find an optimal or suboptimal task scheduling for p AGV\u27s among m workstations to complete n tasks. An efficient approach based on genetic algorithms has been designed and implemented to solve the problem of task scheduling for a FMS. Near-optimal, or even optimal, task scheduling is accomplished by genetic algorithms. Simulation results on the algorithm are also discussed