8,241 research outputs found

    Transmission of monetary policy shocks in Finland: evidence from bank level data on loans

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    We use a panel of quarterly time series observations on Finnish banks to estimate reduced form equations for the growth rate of bank loans. By allowing for individual bank specific effects in the empirical models we specifically seek evidence of a bank-lending channel for the transmission of monetary policy shocks in Finland. On the basis of our estimation results, we conclude that there is weak evidence in favour of the bank-lending channel for monetary policy shocks. Our data overlaps with the post crisis recovery of the Finnish banking sector with specific government support measures still active during the good part of the sample period. We try to capture the effects of these measures through a policy dummy variable in our empirical models. This policy dummy is highly significant, suggesting that the measures may have contributed to the growth rate of bank loans during the sample period JEL Classification: E51, E52, G21banking crisis, credit view, GMM, monetary policy, money view

    The low-mass Initial Mass Function in the young cluster NGC 6611

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    NGC 6611 is the massive young cluster (2-3 Myr) that ionises the Eagle Nebula. We present very deep photometric observations of the central region of NGC 6611 obtained with the Hubble Space Telescope and the following filters: ACS/WFC F775W and F850LP and NIC2 F110W and F160W, loosely equivalent to ground-based IZJH filters. This survey reaches down to I ~ 26 mag. We construct the Initial Mass Function (IMF) from ~ 1.5 Msun well into the brown dwarf regime (down to ~ 0.02 Msun). We have detected 30-35 brown dwarf candidates in this sample. The low-mass IMF is combined with a higher-mass IMF constructed from the groundbased catalogue from Oliveira et al. (2005). We compare the final IMF with those of well studied star forming regions: we find that the IMF of NGC 6611 more closely resembles that of the low-mass star forming region in Taurus than that of the more massive Orion Nebula Cluster (ONC). We conclude that there seems to be no severe environmental effect in the IMF due to the proximity of the massive stars in NGC 6611.Comment: accepted for publication in MNRAS (main journal); 18 pages, 12 figures and 3 table

    AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury.

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    Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms. Peripheral nociceptive stimuli induce maladaptive synaptic plasticity in dorsal horn sensory systems through AMPA receptor (AMPAR) phosphorylation and trafficking to synapses. Here we test whether ventral horn motor neurons in rats demonstrate similar experience-dependent maladaptive plasticity below a complete SCI in vivo. Quantitative biochemistry demonstrated that intermittent nociceptive stimulation (INS) rapidly and selectively increases AMPAR subunit GluA1 serine 831 phosphorylation and localization to synapses in the injured spinal cord, while reducing synaptic GluA2. These changes predict motor dysfunction in the absence of cell death signaling, suggesting an opportunity for therapeutic reversal. Automated confocal time-course analysis of lumbar ventral horn motor neurons confirmed a time-dependent increase in synaptic GluA1 with concurrent decrease in synaptic GluA2. Optical fractionation of neuronal plasma membranes revealed GluA2 removal from extrasynaptic sites on motor neurons early after INS followed by removal from synapses 2 h later. As GluA2-lacking AMPARs are canonical calcium-permeable AMPARs (CP-AMPARs), their stimulus- and time-dependent insertion provides a therapeutic target for limiting calcium-dependent dynamic maladaptive plasticity after SCI. Confirming this, a selective CP-AMPAR antagonist protected against INS-induced maladaptive spinal plasticity, restoring adaptive motor responses on a sensorimotor spinal training task. These findings highlight the critical involvement of AMPARs in experience-dependent spinal cord plasticity after injury and provide a pharmacologically targetable synaptic mechanism by which early postinjury experience shapes motor plasticity

    Image Deblurring Using Derivative Compressed Sensing for Optical Imaging Application

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    Reconstruction of multidimensional signals from the samples of their partial derivatives is known to be a standard problem in inverse theory. Such and similar problems routinely arise in numerous areas of applied sciences, including optical imaging, laser interferometry, computer vision, remote sensing and control. Though being ill-posed in nature, the above problem can be solved in a unique and stable manner, provided proper regularization and relevant boundary conditions. In this paper, however, a more challenging setup is addressed, in which one has to recover an image of interest from its noisy and blurry version, while the only information available about the imaging system at hand is the amplitude of the generalized pupil function (GPF) along with partial observations of the gradient of GPF's phase. In this case, the phase-related information is collected using a simplified version of the Shack-Hartmann interferometer, followed by recovering the entire phase by means of derivative compressed sensing. Subsequently, the estimated phase can be combined with the amplitude of the GPF to produce an estimate of the point spread function (PSF), whose knowledge is essential for subsequent image deconvolution. In summary, the principal contribution of this work is twofold. First, we demonstrate how to simplify the construction of the Shack-Hartmann interferometer so as to make it less expensive and hence more accessible. Second, it is shown by means of numerical experiments that the above simplification and its associated solution scheme produce image reconstructions of the quality comparable to those obtained using dense sampling of the GPF phase

    Optimization Of Zonal Wavefront Estimation And Curvature Measurements

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    Optical testing in adverse environments, ophthalmology and applications where characterization by curvature is leveraged all have a common goal: accurately estimate wavefront shape. This dissertation investigates wavefront sensing techniques as applied to optical testing based on gradient and curvature measurements. Wavefront sensing involves the ability to accurately estimate shape over any aperture geometry, which requires establishing a sampling grid and estimation scheme, quantifying estimation errors caused by measurement noise propagation, and designing an instrument with sufficient accuracy and sensitivity for the application. Starting with gradient-based wavefront sensing, a zonal least-squares wavefront estimation algorithm for any irregular pupil shape and size is presented, for which the normal matrix equation sets share a pre-defined matrix. A Gerchberg–Saxton iterative method is employed to reduce the deviation errors in the estimated wavefront caused by the pre-defined matrix across discontinuous boundary. The results show that the RMS deviation error of the estimated wavefront from the original wavefront can be less than λ/130~ λ/150 (for λ equals 632.8nm) after about twelve iterations and less than λ/100 after as few as four iterations. The presented approach to handling irregular pupil shapes applies equally well to wavefront estimation from curvature data. A defining characteristic for a wavefront estimation algorithm is its error propagation behavior. The error propagation coefficient can be formulated as a function of the eigenvalues of the wavefront estimation-related matrices, and such functions are established for each of the basic estimation geometries (i.e. Fried, Hudgin and Southwell) with a serial numbering scheme, where a square sampling grid array is sequentially indexed row by row. The results show that with the wavefront piston-value fixed, the odd-number grid sizes yield lower error propagation than the even-number grid sizes for all geometries. The Fried geometry either allows sub-sized wavefront estimations within the testing domain or yields a two-rank deficient estimation matrix over the full aperture; but the latter usually suffers from high error propagation and the waffle mode problem. Hudgin geometry offers an error propagator between those of the Southwell and the Fried geometries. For both wavefront gradient-based and wavefront difference-based estimations, the Southwell geometry is shown to offer the lowest error propagation with the minimum-norm least-squares solution. Noll’s theoretical result, which was extensively used as a reference in the previous literature for error propagation estimate, corresponds to the Southwell geometry with an odd-number grid size. For curvature-based wavefront sensing, a concept for a differential Shack-Hartmann (DSH) curvature sensor is proposed. This curvature sensor is derived from the basic Shack-Hartmann sensor with the collimated beam split into three output channels, along each of which a lenslet array is located. Three Hartmann grid arrays are generated by three lenslet arrays. Two of the lenslets shear in two perpendicular directions relative to the third one. By quantitatively comparing the Shack-Hartmann grid coordinates of the three channels, the differentials of the wavefront slope at each Shack-Hartmann grid point can be obtained, so the Laplacian curvatures and twist terms will be available. The acquisition of the twist terms using a Hartmann-based sensor allows us to uniquely determine the principal curvatures and directions more accurately than prior methods. Measurement of local curvatures as opposed to slopes is unique because curvature is intrinsic to the wavefront under test, and it is an absolute as opposed to a relative measurement. A zonal least-squares-based wavefront estimation algorithm was developed to estimate the wavefront shape from the Laplacian curvature data, and validated. An implementation of the DSH curvature sensor is proposed and an experimental system for this implementation was initiated. The DSH curvature sensor shares the important features of both the Shack-Hartmann slope sensor and Roddier’s curvature sensor. It is a two-dimensional parallel curvature sensor. Because it is a curvature sensor, it provides absolute measurements which are thus insensitive to vibrations, tip/tilts, and whole body movements. Because it is a two-dimensional sensor, it does not suffer from other sources of errors, such as scanning noise. Combined with sufficient sampling and a zonal wavefront estimation algorithm, both low and mid frequencies of the wavefront may be recovered. Notice that the DSH curvature sensor operates at the pupil of the system under test, therefore the difficulty associated with operation close to the caustic zone is avoided. Finally, the DSH-curvature-sensor-based wavefront estimation does not suffer from the 2π-ambiguity problem, so potentially both small and large aberrations may be measured

    USA v. Lore

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    USDC for the District of New Jerse
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