1,603 research outputs found

    Multiobjective strategies for New Product Development in the pharmaceutical industry

    Get PDF
    New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

    Multiobjective strategies for New Product Development in the pharmaceutical industry

    Get PDF
    New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline. Formally, the NPD problem can be stated as follows: select a set of R&D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while coping with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGAII type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. This work is illustrated with a study case involving nine interdependent new product candidates targeting three diseases. An analysis is performed for this test bench on the different pairs of criteria both for the bi- and tricriteria optimization: large portfolios cause resource queues and delays time to launch and are eliminated by the bi- and tricriteria optimization strategy. The optimization strategy is thus interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

    Neural combinatorial optimization as an enabler technology to design real-time virtual network function placement decision systems

    Get PDF
    158 p.The Fifth Generation of the mobile network (5G) represents a breakthrough technology for thetelecommunications industry. 5G provides a unified infrastructure capable of integrating over thesame physical network heterogeneous services with different requirements. This is achieved thanksto the recent advances in network virtualization, specifically in Network Function Virtualization(NFV) and Software Defining Networks (SDN) technologies. This cloud-based architecture not onlybrings new possibilities to vertical sectors but also entails new challenges that have to be solvedaccordingly. In this sense, it enables to automate operations within the infrastructure, allowing toperform network optimization at operational time (e.g., spectrum optimization, service optimization,traffic optimization). Nevertheless, designing optimization algorithms for this purpose entails somedifficulties. Solving the underlying Combinatorial Optimization (CO) problems that these problemspresent is usually intractable due to their NP-Hard nature. In addition, solutions to these problems arerequired in close to real-time due to the tight time requirements on this dynamic environment. Forthis reason, handwritten heuristic algorithms have been widely used in the literature for achievingfast approximate solutions on this context.However, particularizing heuristics to address CO problems can be a daunting task that requiresexpertise. The ability to automate this resolution processes would be of utmost importance forachieving an intelligent network orchestration. In this sense, Artificial Intelligence (AI) is envisionedas the key technology for autonomously inferring intelligent solutions to these problems. Combining AI with network virtualization can truly transform this industry. Particularly, this Thesis aims at using Neural Combinatorial Optimization (NCO) for inferring endsolutions on CO problems. NCO has proven to be able to learn near optimal solutions on classicalcombinatorial problems (e.g., the Traveler Salesman Problem (TSP), Bin Packing Problem (BPP),Vehicle Routing Problem (VRP)). Specifically, NCO relies on Reinforcement Learning (RL) toestimate a Neural Network (NN) model that describes the relation between the space of instances ofthe problem and the solutions for each of them. In other words, this model for a new instance is ableto infer a solution generalizing from the problem space where it has been trained. To this end, duringthe learning process the model takes instances from the learning space, and uses the reward obtainedfrom evaluating the solution to improve its accuracy.The work here presented, contributes to the NCO theory in two main directions. First, this workargues that the performance obtained by sequence-to-sequence models used for NCO in the literatureis improved presenting combinatorial problems as Constrained Markov Decision Processes (CMDP).Such property can be exploited for building a Markovian model that constructs solutionsincrementally based on interactions with the problem. And second, this formulation enables toaddress general constrained combinatorial problems under this framework. In this context, the modelin addition to the reward signal, relies on penalty signals generated from constraint dissatisfactionthat direct the model toward a competitive policy even in highly constrained environments. Thisstrategy allows to extend the number of problems that can be addressed using this technology.The presented approach is validated in the scope of intelligent network management, specifically inthe Virtual Network Function (VNF) placement problem. This problem consists of efficientlymapping a set of network service requests on top of the physical network infrastructure. Particularly,we seek to obtain the optimal placement for a network service chain considering the state of thevirtual environment, so that a specific resource objective is accomplished, in this case theminimization of the overall power consumption. Conducted experiments prove the capability of theproposal for learning competitive solutions when compared to classical heuristic, metaheuristic, andConstraint Programming (CP) solvers

    Neural combinatorial optimization as an enabler technology to design real-time virtual network function placement decision systems

    Get PDF
    158 p.The Fifth Generation of the mobile network (5G) represents a breakthrough technology for thetelecommunications industry. 5G provides a unified infrastructure capable of integrating over thesame physical network heterogeneous services with different requirements. This is achieved thanksto the recent advances in network virtualization, specifically in Network Function Virtualization(NFV) and Software Defining Networks (SDN) technologies. This cloud-based architecture not onlybrings new possibilities to vertical sectors but also entails new challenges that have to be solvedaccordingly. In this sense, it enables to automate operations within the infrastructure, allowing toperform network optimization at operational time (e.g., spectrum optimization, service optimization,traffic optimization). Nevertheless, designing optimization algorithms for this purpose entails somedifficulties. Solving the underlying Combinatorial Optimization (CO) problems that these problemspresent is usually intractable due to their NP-Hard nature. In addition, solutions to these problems arerequired in close to real-time due to the tight time requirements on this dynamic environment. Forthis reason, handwritten heuristic algorithms have been widely used in the literature for achievingfast approximate solutions on this context.However, particularizing heuristics to address CO problems can be a daunting task that requiresexpertise. The ability to automate this resolution processes would be of utmost importance forachieving an intelligent network orchestration. In this sense, Artificial Intelligence (AI) is envisionedas the key technology for autonomously inferring intelligent solutions to these problems. Combining AI with network virtualization can truly transform this industry. Particularly, this Thesis aims at using Neural Combinatorial Optimization (NCO) for inferring endsolutions on CO problems. NCO has proven to be able to learn near optimal solutions on classicalcombinatorial problems (e.g., the Traveler Salesman Problem (TSP), Bin Packing Problem (BPP),Vehicle Routing Problem (VRP)). Specifically, NCO relies on Reinforcement Learning (RL) toestimate a Neural Network (NN) model that describes the relation between the space of instances ofthe problem and the solutions for each of them. In other words, this model for a new instance is ableto infer a solution generalizing from the problem space where it has been trained. To this end, duringthe learning process the model takes instances from the learning space, and uses the reward obtainedfrom evaluating the solution to improve its accuracy.The work here presented, contributes to the NCO theory in two main directions. First, this workargues that the performance obtained by sequence-to-sequence models used for NCO in the literatureis improved presenting combinatorial problems as Constrained Markov Decision Processes (CMDP).Such property can be exploited for building a Markovian model that constructs solutionsincrementally based on interactions with the problem. And second, this formulation enables toaddress general constrained combinatorial problems under this framework. In this context, the modelin addition to the reward signal, relies on penalty signals generated from constraint dissatisfactionthat direct the model toward a competitive policy even in highly constrained environments. Thisstrategy allows to extend the number of problems that can be addressed using this technology.The presented approach is validated in the scope of intelligent network management, specifically inthe Virtual Network Function (VNF) placement problem. This problem consists of efficientlymapping a set of network service requests on top of the physical network infrastructure. Particularly,we seek to obtain the optimal placement for a network service chain considering the state of thevirtual environment, so that a specific resource objective is accomplished, in this case theminimization of the overall power consumption. Conducted experiments prove the capability of theproposal for learning competitive solutions when compared to classical heuristic, metaheuristic, andConstraint Programming (CP) solvers

    HYPA: Efficient Detection of Path Anomalies in Time Series Data on Networks

    Full text link
    The unsupervised detection of anomalies in time series data has important applications in user behavioral modeling, fraud detection, and cybersecurity. Anomaly detection has, in fact, been extensively studied in categorical sequences. However, we often have access to time series data that represent paths through networks. Examples include transaction sequences in financial networks, click streams of users in networks of cross-referenced documents, or travel itineraries in transportation networks. To reliably detect anomalies, we must account for the fact that such data contain a large number of independent observations of paths constrained by a graph topology. Moreover, the heterogeneity of real systems rules out frequency-based anomaly detection techniques, which do not account for highly skewed edge and degree statistics. To address this problem, we introduce HYPA, a novel framework for the unsupervised detection of anomalies in large corpora of variable-length temporal paths in a graph. HYPA provides an efficient analytical method to detect paths with anomalous frequencies that result from nodes being traversed in unexpected chronological order.Comment: 11 pages with 8 figures and supplementary material. To appear at SIAM Data Mining (SDM 2020

    Optimización metaheurística aplicada en la gestión de pavimentos asfálticos

    Get PDF
    Pavement engineering is a crossroads between geotechnical and transportation engineering with a sound base on construction materials. There are multiple applications of optimization algorithms in pavement engineering, emphasizing pavement management for its socioeconomic implications and back-calculation of layer properties for its complexity. A detailed literature review shows that optimization has been a permanent concern in pavement engineering. However, only in the last two decades, the increase in computational power allowed the implementation of metaheuristic optimization techniques with promising results in research and practice. Pavement management requires powerful optimization tools for multi-objective problems such as minimizing costs and maximizing the pavement state from network to project level with constrained budgets. A substantial amount of research focuses on genetic algorithms (GA), but new developments include particle intelligence (PSO, ACO, and ABC). The study must go beyond small-sized networks to improve the management of existing road infrastructure (pavement, bridges) based on mechanistic and reliability criteria.La ingeniería de pavimentos es una encrucijada entre la ingeniería geotécnica y la ingeniería de transporte con una sólida base en los materiales de construcción. Existen diferentes aplicaciones de los algoritmos de optimización en la ingeniería de pavimentos, las cuales enfatizan la gestión del pavimento por sus implicaciones socioeconómicas y el cálculo inverso de las propiedades de las capas por su complejidad. Una revisión detallada de la literatura muestra que la optimización ha sido una preocupación permanente en la ingeniería de pavimentos; sin embargo, solo en las últimas dos décadas, el incremento del poder computacional permitió la implementación de técnicas de optimización metaheurísticas con resultados prometedores en la investigación y en la práctica. La gestión del pavimento requiere poderosas herramientas de optimización para problemas con objetivos múltiples, como minimizar costos y maximizar el estado del pavimento desde el nivel de la red hasta el del proyecto con presupuestos limitados. Una cantidad sustancial de investigaciones se centra en los algoritmos genéticos (AG), pero los nuevos desarrollos incluyen inteligencia de partículas (PSO, ACO y ABC). El estudio debe ir más allá de las redes de pequeño tamaño para mejorar la gestión de la infraestructura vial existente (pavimento, puentes) con base en criterios mecanicistas y de confiabilidad
    corecore