Understanding Silent Failures in Medical Image Classification

To ensure the reliable use of classification systems in medical applications, it is crucial to prevent silent failures. This can be achieved by either designing classifiers that are robust enough to avoid failures in the first place, or by detecting remaining failures using confidence scoring functions (CSFs). A predominant source of failures in image classification is distribution shifts between training data and deployment data. To understand the current state of silent failure prevention in medical imaging, we conduct the first comprehensive analysis comparing various CSFs in four biomedical tasks and a diverse range of distribution shifts. Based on the result that none of the benchmarked CSFs can reliably prevent silent failures, we conclude that a deeper understanding of the root causes of failures in the data is required. To facilitate this, we introduce SF-Visuals, an interactive analysis tool that uses latent space clustering to visualize shifts and failures. On the basis of various examples, we demonstrate how this tool can help researchers gain insight into the requirements for safe application of classification systems in the medical domain. The open-source benchmark and tool are at: https://github.com/IML-DKFZ/sf-visuals.Comment: Accepted at MICCAI 2

Towards a Comprehensible and Accurate Credit Management Model: Application of four Computational Intelligence Methodologies

The paper presents methods for classification of applicants into different categories of credit risk using four different computational intelligence techniques. The selected methodologies involved in the rule-based categorization task are (1) feedforward neural networks trained with second order methods (2) inductive machine learning, (3) hierarchical decision trees produced by grammar-guided genetic programming and (4) fuzzy rule based systems produced by grammar-guided genetic programming. The data used are both numerical and linguistic in nature and they represent a real-world problem, that of deciding whether a loan should be granted or not, in respect to financial details of customers applying for that loan, to a specific private EU bank. We examine the proposed classification models with a sample of enterprises that applied for a loan, each of which is described by financial decision variables (ratios), and classified to one of the four predetermined classes. Attention is given to the comprehensibility and the ease of use for the acquired decision models. Results show that the application of the proposed methods can make the classification task easier and - in some cases - may minimize significantly the amount of required credit data. We consider that these methodologies may also give the chance for the extraction of a comprehensible credit management model or even the incorporation of a related decision support system in bankin

Revisiting knowledge transfer for training object class detectors

We propose to revisit knowledge transfer for training object detectors on target classes from weakly supervised training images, helped by a set of source classes with bounding-box annotations. We present a unified knowledge transfer framework based on training a single neural network multi-class object detector over all source classes, organized in a semantic hierarchy. This generates proposals with scores at multiple levels in the hierarchy, which we use to explore knowledge transfer over a broad range of generality, ranging from class-specific (bicycle to motorbike) to class-generic (objectness to any class). Experiments on the 200 object classes in the ILSVRC 2013 detection dataset show that our technique: (1) leads to much better performance on the target classes (70.3% CorLoc, 36.9% mAP) than a weakly supervised baseline which uses manually engineered objectness [11] (50.5% CorLoc, 25.4% mAP). (2) delivers target object detectors reaching 80% of the mAP of their fully supervised counterparts. (3) outperforms the best reported transfer learning results on this dataset (+41% CorLoc and +3% mAP over [18, 46], +16.2% mAP over [32]). Moreover, we also carry out several across-dataset knowledge transfer experiments [27, 24, 35] and find that (4) our technique outperforms the weakly supervised baseline in all dataset pairs by 1.5x-1.9x, establishing its general applicability.Comment: CVPR 1

ICE: Enabling Non-Experts to Build Models Interactively for Large-Scale Lopsided Problems

Quick interaction between a human teacher and a learning machine presents numerous benefits and challenges when working with web-scale data. The human teacher guides the machine towards accomplishing the task of interest. The learning machine leverages big data to find examples that maximize the training value of its interaction with the teacher. When the teacher is restricted to labeling examples selected by the machine, this problem is an instance of active learning. When the teacher can provide additional information to the machine (e.g., suggestions on what examples or predictive features should be used) as the learning task progresses, then the problem becomes one of interactive learning. To accommodate the two-way communication channel needed for efficient interactive learning, the teacher and the machine need an environment that supports an interaction language. The machine can access, process, and summarize more examples than the teacher can see in a lifetime. Based on the machine's output, the teacher can revise the definition of the task or make it more precise. Both the teacher and the machine continuously learn and benefit from the interaction. We have built a platform to (1) produce valuable and deployable models and (2) support research on both the machine learning and user interface challenges of the interactive learning problem. The platform relies on a dedicated, low-latency, distributed, in-memory architecture that allows us to construct web-scale learning machines with quick interaction speed. The purpose of this paper is to describe this architecture and demonstrate how it supports our research efforts. Preliminary results are presented as illustrations of the architecture but are not the primary focus of the paper

Spotlight the Negatives: A Generalized Discriminative Latent Model

Discriminative latent variable models (LVM) are frequently applied to various visual recognition tasks. In these systems the latent (hidden) variables provide a formalism for modeling structured variation of visual features. Conventionally, latent variables are de- fined on the variation of the foreground (positive) class. In this work we augment LVMs to include negative latent variables corresponding to the background class. We formalize the scoring function of such a generalized LVM (GLVM). Then we discuss a framework for learning a model based on the GLVM scoring function. We theoretically showcase how some of the current visual recognition methods can benefit from this generalization. Finally, we experiment on a generalized form of Deformable Part Models with negative latent variables and show significant improvements on two different detection tasks.Comment: Published in proceedings of BMVC 201

Supersparse Linear Integer Models for Optimized Medical Scoring Systems

Scoring systems are linear classification models that only require users to add, subtract and multiply a few small numbers in order to make a prediction. These models are in widespread use by the medical community, but are difficult to learn from data because they need to be accurate and sparse, have coprime integer coefficients, and satisfy multiple operational constraints. We present a new method for creating data-driven scoring systems called a Supersparse Linear Integer Model (SLIM). SLIM scoring systems are built by solving an integer program that directly encodes measures of accuracy (the 0-1 loss) and sparsity (the $\ell_0$-seminorm) while restricting coefficients to coprime integers. SLIM can seamlessly incorporate a wide range of operational constraints related to accuracy and sparsity, and can produce highly tailored models without parameter tuning. We provide bounds on the testing and training accuracy of SLIM scoring systems, and present a new data reduction technique that can improve scalability by eliminating a portion of the training data beforehand. Our paper includes results from a collaboration with the Massachusetts General Hospital Sleep Laboratory, where SLIM was used to create a highly tailored scoring system for sleep apnea screeningComment: This version reflects our findings on SLIM as of January 2016 (arXiv:1306.5860 and arXiv:1405.4047 are out-of-date). The final published version of this articled is available at http://www.springerlink.co