Multi-layered Spiking Neural Network with Target Timestamp Threshold Adaptation and STDP

Spiking neural networks (SNNs) are good candidates to produce ultra-energy-efficient hardware. However, the performance of these models is currently behind traditional methods. Introducing multi-layered SNNs is a promising way to reduce this gap. We propose in this paper a new threshold adaptation system which uses a timestamp objective at which neurons should fire. We show that our method leads to state-of-the-art classification rates on the MNIST dataset (98.60%) and the Faces/Motorbikes dataset (99.46%) with an unsupervised SNN followed by a linear SVM. We also investigate the sparsity level of the network by testing different inhibition policies and STDP rules

A PAUC-based Estimation Technique for Disease Classification and Biomarker Selection.

The partial area under the receiver operating characteristic curve (PAUC) is a well-established performance measure to evaluate biomarker combinations for disease classification. Because the PAUC is defined as the area under the ROC curve within a restricted interval of false positive rates, it enables practitioners to quantify sensitivity rates within pre-specified specificity ranges. This issue is of considerable importance for the development of medical screening tests. Although many authors have highlighted the importance of PAUC, there exist only few methods that use the PAUC as an objective function for finding optimal combinations of biomarkers. In this paper, we introduce a boosting method for deriving marker combinations that is explicitly based on the PAUC criterion. The proposed method can be applied in high-dimensional settings where the number of biomarkers exceeds the number of observations. Additionally, the proposed method incorporates a recently proposed variable selection technique (stability selection) that results in sparse prediction rules incorporating only those biomarkers that make relevant contributions to predicting the outcome of interest. Using both simulated data and real data, we demonstrate that our method performs well with respect to both variable selection and prediction accuracy. Specifically, if the focus is on a limited range of specificity values, the new method results in better predictions than other established techniques for disease classification

Machine learning-guided synthesis of advanced inorganic materials

Synthesis of advanced inorganic materials with minimum number of trials is of paramount importance towards the acceleration of inorganic materials development. The enormous complexity involved in existing multi-variable synthesis methods leads to high uncertainty, numerous trials and exorbitant cost. Recently, machine learning (ML) has demonstrated tremendous potential for material research. Here, we report the application of ML to optimize and accelerate material synthesis process in two representative multi-variable systems. A classification ML model on chemical vapor deposition-grown MoS2 is established, capable of optimizing the synthesis conditions to achieve higher success rate. While a regression model is constructed on the hydrothermal-synthesized carbon quantum dots, to enhance the process-related properties such as the photoluminescence quantum yield. Progressive adaptive model is further developed, aiming to involve ML at the beginning stage of new material synthesis. Optimization of the experimental outcome with minimized number of trials can be achieved with the effective feedback loops. This work serves as proof of concept revealing the feasibility and remarkable capability of ML to facilitate the synthesis of inorganic materials, and opens up a new window for accelerating material development

Learning sound representations using trainable COPE feature extractors

Sound analysis research has mainly been focused on speech and music processing. The deployed methodologies are not suitable for analysis of sounds with varying background noise, in many cases with very low signal-to-noise ratio (SNR). In this paper, we present a method for the detection of patterns of interest in audio signals. We propose novel trainable feature extractors, which we call COPE (Combination of Peaks of Energy). The structure of a COPE feature extractor is determined using a single prototype sound pattern in an automatic configuration process, which is a type of representation learning. We construct a set of COPE feature extractors, configured on a number of training patterns. Then we take their responses to build feature vectors that we use in combination with a classifier to detect and classify patterns of interest in audio signals. We carried out experiments on four public data sets: MIVIA audio events, MIVIA road events, ESC-10 and TU Dortmund data sets. The results that we achieved (recognition rate equal to 91.71% on the MIVIA audio events, 94% on the MIVIA road events, 81.25% on the ESC-10 and 94.27% on the TU Dortmund) demonstrate the effectiveness of the proposed method and are higher than the ones obtained by other existing approaches. The COPE feature extractors have high robustness to variations of SNR. Real-time performance is achieved even when the value of a large number of features is computed.Comment: Accepted for publication in Pattern Recognitio

Spatio-temporal risk assessment models for Lobesia botrana in uncolonized winegrowing areas

The objective of this work was to generate a series of equations to describe the voltinism of Lobesia botrana in the quarantine area of the main winemaking area of Argentina, Mendoza. To do this we considered an average climate scenario and extrapolatedthese equations to other winegrowing areas at risk of being invaded. A grid of 4 km2was used to generate statistics on L. botrana captures and the mean temperature accumulation for the pixel. Four sets of logistic regression were constructed using the percentage of accumulated trap catches/grid/week and the degree-day accumulation above7°C, from 1st July. By means of a habitat model, an extrapolation of the phenologicalmodel generated to other Argentine winemaking areas was evaluated. According to ourresults, it can be expected that 50% of male adult emergence for the first flight occurs at248.79 ± 4 degree-days (DD), in the second flight at 860.18 ± 4.1 DD, while in the thirdand the fourth flights, 1671.34 ± 5.8 DD and 2335.64 ± 4.3 DD, respectively. Subsequentclimatic comparison determined that climatic conditions of uncolonized areas of Cuyo Region have a similar suitability index to the quarantine area used to adjust the phenologicalmodel. The upper valley of Río Negro and Neuquén are environmentally similar. Valleys ofthe northwestern region of Argentina showed lower average suitability index and greatervariability among SI estimated by the algorithm considered. The combination of two models for the estimation of adult emergence time and potential distribution, can provide greater certainties in decision-making and risk assessment of invasive species.Fil: Heit, Guillermo Eugenio. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Producción Vegetal; ArgentinaFil: Sione, Walter Fabian. Universidad Autónoma de Entre Ríos; ArgentinaFil: Aceñolaza, Pablo Gilberto. Universidad Nacional de Entre Ríos; Argentina. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentin

Sparse Proteomics Analysis - A compressed sensing-based approach for feature selection and classification of high-dimensional proteomics mass spectrometry data

Background: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. In a clinical setting one is often interested in how mass spectra differ between patients of different classes, for example spectra from healthy patients vs. spectra from patients having a particular disease. Machine learning algorithms are needed to (a) identify these discriminating features and (b) classify unknown spectra based on this feature set. Since the acquired data is usually noisy, the algorithms should be robust against noise and outliers, while the identified feature set should be as small as possible. Results: We present a new algorithm, Sparse Proteomics Analysis (SPA), based on the theory of compressed sensing that allows us to identify a minimal discriminating set of features from mass spectrometry data-sets. We show (1) how our method performs on artificial and real-world data-sets, (2) that its performance is competitive with standard (and widely used) algorithms for analyzing proteomics data, and (3) that it is robust against random and systematic noise. We further demonstrate the applicability of our algorithm to two previously published clinical data-sets