Genomic Prediction of Breeding Values Using a Subset of SNPs Identified by Three Machine Learning Methods

The analysis of large genomic data is hampered by issues such as a small number of observations and a large number of predictive variables (commonly known as “large P small N”), high dimensionality or highly correlated data structures. Machine learning methods are renowned for dealing with these problems. To date machine learning methods have been applied in Genome-Wide Association Studies for identification of candidate genes, epistasis detection, gene network pathway analyses and genomic prediction of phenotypic values. However, the utility of two machine learning methods, Gradient Boosting Machine (GBM) and Extreme Gradient Boosting Method (XgBoost), in identifying a subset of SNP makers for genomic prediction of breeding values has never been explored before. In this study, using 38,082 SNP markers and body weight phenotypes from 2,093 Brahman cattle (1,097 bulls as a discovery population and 996 cows as a validation population), we examined the efficiency of three machine learning methods, namely Random Forests (RF), GBM and XgBoost, in (a) the identification of top 400, 1,000, and 3,000 ranked SNPs; (b) using the subsets of SNPs to construct genomic relationship matrices (GRMs) for the estimation of genomic breeding values (GEBVs). For comparison purposes, we also calculated the GEBVs from (1) 400, 1,000, and 3,000 SNPs that were randomly selected and evenly spaced across the genome, and (2) from all the SNPs. We found that RF and especially GBM are efficient methods in identifying a subset of SNPs with direct links to candidate genes affecting the growth trait. In comparison to the estimate of prediction accuracy of GEBVs from using all SNPs (0.43), the 3,000 top SNPs identified by RF (0.42) and GBM (0.46) had similar values to those of the whole SNP panel. The performance of the subsets of SNPs from RF and GBM was substantially better than that of evenly spaced subsets across the genome (0.18–0.29). Of the three methods, RF and GBM consistently outperformed the XgBoost in genomic prediction accuracy

Microgrids

Microgrids are a growing segment of the energy industry, representing a paradigm shift from centralized structures toward more localized, autonomous, dynamic, and bi-directional energy networks, especially in cities and communities. The ability to isolate from the larger grid makes microgrids resilient, while their capability of forming scalable energy clusters permits the delivery of services that make the grid more sustainable and competitive. Through an optimal design and management process, microgrids could also provide efficient, low-cost, clean energy and help to improve the operation and stability of regional energy systems. This book covers these promising and dynamic areas of research and development and gathers contributions on different aspects of microgrids in an aim to impart higher degrees of sustainability and resilience to energy systems

Towards Artificial General Intelligence (AGI) in the Internet of Things (IoT): Opportunities and Challenges

Artificial General Intelligence (AGI), possessing the capacity to comprehend, learn, and execute tasks with human cognitive abilities, engenders significant anticipation and intrigue across scientific, commercial, and societal arenas. This fascination extends particularly to the Internet of Things (IoT), a landscape characterized by the interconnection of countless devices, sensors, and systems, collectively gathering and sharing data to enable intelligent decision-making and automation. This research embarks on an exploration of the opportunities and challenges towards achieving AGI in the context of the IoT. Specifically, it starts by outlining the fundamental principles of IoT and the critical role of Artificial Intelligence (AI) in IoT systems. Subsequently, it delves into AGI fundamentals, culminating in the formulation of a conceptual framework for AGI's seamless integration within IoT. The application spectrum for AGI-infused IoT is broad, encompassing domains ranging from smart grids, residential environments, manufacturing, and transportation to environmental monitoring, agriculture, healthcare, and education. However, adapting AGI to resource-constrained IoT settings necessitates dedicated research efforts. Furthermore, the paper addresses constraints imposed by limited computing resources, intricacies associated with large-scale IoT communication, as well as the critical concerns pertaining to security and privacy

Social Entrepreneurship:Societal Wealth Creation Under Conditions of Near-Knightian Uncertainty

In this dissertation I examine the emergent phenomenon of social entrepreneurship through the lens of the structure of entrepreneurial payoffs under conditions of near-Knightian uncertainty. Current theory assumes entrepreneurs will respond to a new form of incentive, beyond the pursuits of wealth, power, and prestige. It also assumes that productive entrepreneurship can result from a shift in the structure of payoffs. I examine four for-profit social entrepreneurial experiments executed in Southern Africa in order to enhance understanding of the question: "What recurring challenges do for-profit social entrepreneurs face in attempting to restructure payoffs under conditions of near-Knightian uncertainty?" My data are drawn from field observations, company archival records, email communications, and unique targeted interventions designed to solve vexing challenges which arose in the course of the experiments. The dissertation makes several contributions. First, it uncovers several new insights from my findings which should inform future research in for-profit social enterprises. Second, it sheds light on enterprise creation under conditions of near-Knightian uncertainty. Third, it introduces a framework for understanding the challenges faced by nonsingular objective firms, and proposes that lack of success in the creation of such firms is not necessarily failure – there are multiple levels of success that are part of an Aspirations Cascade, the highest efficiency being delivered by the social impact enterprise and the lowest efficiency achieved from direct charity

Abstracts of Papers, 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond VA

Full abstracts of the 89th Annual Meeting of the Virginia Academy of Science, May 25-27, 2011, University of Richmond, Richmond V