brat: a Web-based Tool for NLP-Assisted Text Annotation

We introduce the brat rapid annotation tool (BRAT), an intuitive web-based tool for text annotation supported by Natural Language Processing (NLP) technology. BRAT has been developed for rich structured annotation for a variety of NLP tasks and aims to support manual curation efforts and increase annotator productivity using NLP techniques. We discuss several case studies of real-world annotation projects using pre-release versions of BRAT and present an evaluation of annotation assisted by semantic class disambiguation on a multicategory entity mention annotation task, showing a 15 % decrease in total annotation time. BRAT is available under an opensource license from

The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog.

Cognitive deficits in schizophrenia are a major source of dysfunction for which more effective treatments are needed. The vasopressin-deficient Brattleboro (BRAT) rat has been shown to have several natural schizophrenia-like deficits, including impairments in prepulse inhibition and memory. We investigated BRAT rats and their parental strain, Long-Evans (LE) rats, in a social discrimination paradigm, which is an ethologically relevant animal test of cognitive deficits of schizophrenia based upon the natural preference of animals to investigate conspecifics. We also investigated the effects of the atypical antipsychotic, clozapine, and the putative antipsychotic, PD149163, a brain-penetrating neurotensin-1 agonist, on social discrimination in these rats. Adult rats were administered saline or one of the three doses of clozapine (0.1, 1.0, or 10 mg/kg) or PD149163 (0.1, 0.3, or 1.0 mg/kg), subcutaneously. Following drug administration, adult rats were exposed to a juvenile rat for a 4-min learning period. Animals were then housed individually for 30 min and then simultaneously exposed to the juvenile presented previously and a new juvenile for 4 min. Saline-treated LE rats, but not BRAT rats, exhibited intact social discrimination as evidenced by greater time spent exploring the new juvenile. The highest dose of clozapine and the two highest doses of PD149163 restored social discrimination in BRAT rats. These results provide further support for the utility of the BRAT rat as a genetic animal model relevant to schizophrenia and drug discovery. The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported

Brat

Brat (1997, RU) by Aleksei Balabanov Main Cast: Sergei Bodrov Jr.; Viktor Sukhorukov; Company: Gorky Filmstudios The movie is about young man Danila who has been just released from the army and came back from Chechnya to his home village. He had nothing to do and moved to St. Petersburg to his elder brother who has a “big business”. His brother turned to be a killer. He asked Danila to help him and to assassinate several people; Danila did it very professionally. At the end his brother betrayed him but Danila forgave him and saved from the gangsters since he was his brother. Scene: alcohol male adults strong nontransgressive in company 0:25:34-0:26:12: alcohol In the second scene we can see Danila and Zina, who is German’s friend, coming to the flat, where Danila could rent a room. The owner of the room is an old mad alcoholic. First he can’t even recall who Zina is though they are good friends. He is very afraid of everything and can’t separate from his gun. Clip: 10

Brat

Brat (1997, RU) by Aleksei Balabanov Main Cast: Sergei Bodrov Jr.; Viktor Sukhorukov; Company: Gorky Filmstudios The movie is about young man Danila who has been just released from the army and came back from Chechnya to his home village. He had nothing to do and moved to St. Petersburg to his elder brother who has a “big business”. His brother turned to be a killer. He asked Danila to help him and to assassinate several people; Danila did it very professionally. At the end his brother betrayed him but Danila forgave him and saved from the gangsters since he was his brother. Scene: alcohol male mixed strong tobacco nontransgressive in company 0:12:47-0:13:31: alcohol The first scene shows us Danila coming to the cemetery with his new friend German who is homeless. Danila has not still found his brother; he helps German when the gangsters want to take his last money and comes with him to the place where German and his homeless friends use to meet. It is the grave of his ancestors. They give him vodka and Danila suggests some pie that his mother gave him for the brother. Clip: 10

Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons

Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in Drosophila motoneurons. In this current study, we show that Pum is able to bind directly the mRNA encoding the Drosophila voltage-gated sodium channel paralytic (para). We identify a putative binding site for Pum in the 3' end of the para open reading frame (ORF). Characterization of the mechanism of action of Pum, using whole-cell patch clamp and real-time reverse transcription-PCR, reveals that the full-length protein is required for translational repression of para mRNA. Additionally, the cofactor Nanos is essential for Pum-dependent para repression, whereas the requirement for Brain Tumor (Brat) is cell type specific. Thus, Pum-dependent regulation of INa in motoneurons requires both Nanos and Brat, whereas regulation in other neuronal types seemingly requires only Nanos but not Brat. We also show that Pum is able to reduce the level of nanos mRNA and as such identify a potential negative-feedback mechanism to protect neurons from overactivity of Pum. Finally, we show coupling between INa (para) and IK (Shal) such that Pum-mediated change in para results in a compensatory change in Shal. The identification of para as a direct target of Pum represents the first ion channel to be translationally regulated by this repressor and the location of the binding motif is the first example in an ORF rather than in the canonical 3'-untranslated region of target transcripts

Brat

Brat (1997, RU) by Aleksei Balabanov Main Cast: Sergei Bodrov Jr.; Viktor Sukhorukov; Company: Gorky Filmstudios The movie is about young man Danila who has been just released from the army and came back from Chechnya to his home village. He had nothing to do and moved to St. Petersburg to his elder brother who has a “big business”. His brother turned to be a killer. He asked Danila to help him and to assassinate several people; Danila did it very professionally. At the end his brother betrayed him but Danila forgave him and saved from the gangsters since he was his brother. Scene: alcohol male adults strong nontransgressive in company 0:25:34-0:26:12: alcohol In the second scene we can see Danila and Zina, who is German’s friend, coming to the flat, where Danila could rent a room. The owner of the room is an old mad alcoholic. First he can’t even recall who Zina is though they are good friends. He is very afraid of everything and can’t separate from his gun. Clip: 10

Wozu Dichter?

Goethe's Tasso is no "Dichter in duerftiger Zeit." He is rather duerftig himself, unbalanced and impulsive in the extreme. In fact, in an annoyed moment, the diplomat Antonio sees him as a useless and pampered brat and undiplomatically says so, triggering a fateful sequence of events that generate a seemingly unstoppable momentum

Prioritization of beaver (Castor canadensis) reintroduction sites within semi-arid grassland rivers in the Great Plains

2020 Spring.Includes bibliographical references.River restoration has become more of a concern with human influence on natural systems on the rise. Beaver provide a relatively inexpensive and natural opportunity to restore rivers to a pre-settlement state. Quantitative models can be used to better understand where beaver reintroduction should occur to maximize the odds of a reintroduced beaver population establishing an ideal habitat to thrive in. The Beaver Restoration Assessment Tool (BRAT) is a quantitative model that uses elevation, hydrology, and vegetation inputs to estimate the carrying capacity of beaver. The primary objective of this project is to develop baseline data that can inform river restoration of the Dale Creek watershed on Old Elk Ranch, a northern tributary to the Poudre River in Northern Colorado, although the methods used in this study are broadly applicable to other watersheds. This objective was addressed during two phases of work – the channel and riparian condition assessment during summer 2018 and the assessment of historic and contemporary potential beaver habitat using BRAT and field surveys during summer 2019. Through the utilization of BRAT, survey mapping, and remote sensing, I was further able to determine the best methods for estimating potential beaver population density, as well as the accuracy of the BRAT results relative to the field survey results. Remote sensing provides a unique opportunity to increase the accuracy of BRAT through image classification and analysis. A national vegetation dataset produced by LANDFIRE, with a spatial resolution of 10m, is not as spatially accurate as vegetation datasets derived though supervised classification of NAIP imagery with a 1m spatial resolution. Due to its coarser spatial resolution and being a product of generalized models and field data, LANDFIRE data missed important details in vegetation, such as riparian willows along valley bottoms and variabilities within the floodplain that are crucial for beaver survival. Furthermore, this increase in vegetation accuracy led to increasing the accuracy of BRAT predictions for beaver carrying capacity relative to ground-based mapping of past beaver occupation, allowing for better assessment of where beaver should be reintroduced. Historical BRAT estimates revealed that zero and 1st order channels had the highest carrying capacity of dams historically, accounting for 56% of reaches capable of the highest BRAT classification (15+ dams/km). According to the field survey and historical vs contemporary BRAT estimates, carrying capacity has been greatly reduced post human settlement, primarily in zero and 1st order channel valleys where cattle were introduced. The 2018 condition assessment confirmed that while riparian vegetation was healthiest in higher-order channels, zero and 1st order channels were heavily browsed by cattle, deer, and elk. Based on the distribution of riparian vegetation health, and carrying capacity estimates from BRAT and field surveys, stream restoration would be most effective on 0th and 1st order streams

Daftar Isi - Candra Brata

Daftar Isi - Candra Brat