BIOTECHNOLOGY, A FARMER'S PERSPECTIVE

Research and Development/Tech Change/Emerging Technologies,

Health Biotechnology Innovation for Social Sustainability -A Perspective from China

China is not only becoming a significant player in the production of high-tech products, but also an increasingly important contributor of ideas and influence in the global knowledge economy. This paper identifies the promises and the pathologies of the biotech innovation system from the perspective of social sustainability in China, looking at the governance of the system and beyond. Based on The STEPS Centre’s ‘Innovation, Sustainability, Development: A New Manifesto’, a ‘3D’ approach has been adopted, bringing together social, technological and policy dynamics, and focusing on the directions of biotechnological innovation, the distribution of its benefits, costs and risks and the diversity of innovations evolving within it and alongside it

THE ECONOMICS OF BIOSAFETY: IMPLICATIONS FOR BIOTECHNOLOGY IN DEVELOPING COUNTRIES

There is a growing body of literature on the safe use of biotechnology and the need for an international biosafety protocol and national regulations to facilitate the safe development and transfer of biotechnology. Most of these studies, however, address the issue of biosafety from a scientific, legal, environmental and organizational perspective. The purpose of this paper is to add to this discussion by providing an economic perspective on regulating products of agricultural biotechnology, with special emphasis on implications for developing countries who are under increasing pressure to put a biosafety framework in place. The paper provides a brief discussion on the economic rationale for biosafety regulations, explains the economic benefits and costs of biosafety, and discusses the appropriate form of biosafety policy and the effects of regulation on resource allocation. The benefits of biosafety discussed include - the reduction of possible human and environmental risks of biotechnology products and "accident" costs to the society; increased predictability for a research organization of the expected time and money to get a new product on the market; making the products of biotechnology accessible to a country; and the provision of certainty and stability to the social framework, necessary for the development of biotechnology research and development activities. Developing countries should balance these potential benefits with the tangible costs of biosafety regulation to the biotechnology organizations and the society. To a biotechnology organization, biosafety will increase the research lag, production costs, transaction costs and marketing costs. Given the scarcity of human and physical resources, setting up a biosafety system also poses opportunity costs to the society. The following issues need careful examination in designing a biosafety policy in a developing country: the goal of biosafety policy; the appropriate means of controlling risk; the impact of biosafety on scientific development and private investments; the impact of biosafety on the international transfer of technology and international trade; the incidence of biosafety costs; and the size of biosafety system. Keywords: Biosafety, economic aspects, developing countries, agriculture, biotechnology, researchBiosafety, economic aspects, developing countries, agriculture, biotechnology, research, Research and Development/Tech Change/Emerging Technologies,

A biotechnology perspective of fungal proteases

Proteases hydrolyze the peptide bonds of proteins into peptides and amino acids, being found in all living organisms, and are essential for cell growth and differentiation. Proteolytic enzymes have potential application in a wide number of industrial processes such as food, laundry detergent and pharmaceutical. Proteases from microbial sources have dominated applications in industrial sectors. Fungal proteases are used for hydrolyzing protein and other components of soy beans and wheat in soy sauce production. Proteases can be produced in large quantities in a short time by established methods of fermentation. The parameters such as variation in C/N ratio, presence of some sugars, besides several other physical factors are important in the development of fermentation process. Proteases of fungal origin can be produced cost effectively, have an advantage faster production, the ease with which the enzymes can be modified and mycelium can be easily removed by filtration. The production of proteases has been carried out using submerged fermentation, but conditions in solid state fermentation lead to several potential advantages for the production of fungal enzymes. This review focuses on the production of fungal proteases, their distribution, structural-functional aspects, physical and chemical parameters, and the use of these enzymes in industrial applications

Cluster Performance reconsidered: Structure, Linkages and Paths in the German Biotechnology Industry, 1996-2003

This paper addresses the evolution of biotechnology clusters in Germany between 1996 and 2003, paying particular attention to their respective composition in terms of venture capital, basic science institutions and biotechnology firms. Drawing upon the significance of co-location of "money and ideas", the literature stressing the importance of a cluster's openness and external linkages, and the path dependency debate, the paper aims to analyse how certain cluster characteristics correspond with its overall performance. After identifying different cluster types, we investigate their internal and external interconnectivity in comparative manner and draw on changes in cluster composition. Our results indicate that the structure, i.e. to which group the cluster belongs, and the openness towards external knowledge flows deliver merely unsystematic indications with regard to a cluster's overall success. Its ability to change composition towards a more balanced ratio of science and capital over time, on the other hand, turns out as a key explanatory factor. Hence, the dynamic perspective proves effective illuminating cluster growth and performance, where our explorative findings provide a promising avenue for further evolutionary research.Cluster evolution; dynamic perspective; basic science; venture capital; biotechnology; Germany

Research Tool Patents and Free-Libre Biotechnology: A Unified Perspective.

This paper proposes a unified conceptual framework to analyse the multiple role and consequences of patents in the case of biotechnology research tools. We argue that the knowledge/information and independent/complementary nature of research tools define heterogeneous frameworks in which the patent system plays different roles. In particular, using the analogy with the free-libre open source movement in software, we show that patents can promote open innovation by ensuring the freedom of some pieces of knowledge. A strong conclusion of the paper is therefore that, against common belief, an adequate use of the patent system may contribute to preserving freedom of access to upstream research tools within a framework that we call free-libre biotechnology.Intellectual property rights, sequential innovation, open source, life science, collective invention.

Analysis on the evolution and governance of the biotechnology industry of China

The past twenty years have witnessed the high-speed growth of China’s biotechnology industry, and this presents an excellent opportunity to examine the changes that have taken place, especially, to carry out overall evaluation and governance analysis from the perspective of technology policies. Although China’s biotechnology industry has achieved tremendous extension both in scale and structure, the strengths it gained from basic research have been significantly weakened by commercialization. This has resulted in the comparatively limited scale of the whole industry, innovation-lacking products, poor output from research and development and scarcity of industrial resources. A large range of literature regarding China’s biotechnology industry attributes these outcomes to vague and even inappropriate governance, findings supported mainly by analyses based on the linear model of impact of government policies on industrial development. In these analyses, government, enterprises and companies as well as R&D organizations are either put on the opposite poles or in a straight line. After examining the nature of China’s biotechnology industry, and in particular the dynamic procedures in research and development, the authors of this paper argue that besides government, enterprises and R&D organizations, a diverse array of factors should be taken into account as we tackle issues emerging in understanding the development of China’s biotechnology industry. Furthermore, these factors, human or nonhuman, should not be arranged as opposing poles or linearly connected points on a straight line. They are in fact all knitted in networks and act as both knitters and knots. China’s biotechnology industry gains its strength to develop and evolve from these networks, thus its governance must be aimed at improving their stability and quality. Although the main disciplinary perspectives of this research are historical and sociological (including identification of the three development stages of biotechnology in China since 1978 to present days), a large number of concepts and ideas from management studies as well as an interdisciplinary approach are also incorporated into the analysis. The main model used in this research is Actor Network Theory, which is employed as a basic theoretical frame. From this starting point the authors attempt to make a closer examination of China’s biotechnology industry both at the level of technology research and development and at the level of commercialization. The modeling process in this research can be regarded as an attempt to explore the social construction of China’s biotechnology industry. The paper reveals how China’s biotechnology industry develops in the form of networks within the country’s social context and what kinds of relationships exist among the relevant factors; therefore, providing guiding insights for improving the governance of China’s biotechnology industry both in policy and management

Rough Road to Market: Institutional Barriers to Innovations in Africa

Translating R&D and inventive efforts into a market product is characterized by significant financial skills, and the ability to overcome technical and instititonal barriers. Research into and translation of new technologies such as biotechnology products to the market requires even greater resources. This paper aims to understand the key factors that foster or hinder the complex process of translating R&D efforts into innovative products. Different pathways exist in developed countries such as firm-level efforts, the use of IPs, the spin-off of new firms that develop new products, or a mixture of these. Developing countries differ substantially in the kinds of instruments they use because of their considerably weaker institutional environment and for this reason our framework takes a systemic and institutional perspective. The paper comtributes to this issue by examining systemic institutional barriers to commercializing biotechnology in a develping context within a systems of innovation framework.research and development, biotechnology, commercialization, innovation, Africa, learning, institution building

Biotechnology policy implementation from a systems perspective

This study utilizes Viable System Model (VSM) in diagnosing one policy implementation call Malaysian Biotechnology policy. The policy implementation is viewed from the innovation theory, which regards research and development (R&D) as the core of innovation commercialization, which in turn become the nucleus for a firm’s growth. Subsequently, the growth of firms as a group can lead to an industry’s development. This study conducted interviews with the agencies involved in the policy implementation and took advantage of the extensive information relating to the agencies that are available in the public domain, by using content analysis as the study’s methodology. This study enhances the understanding on the full use of VSM; it provides policy makers and implementers a guide in improving existing systems or designing new ones, while researchers are afforded an applicable theoretical conceptualization from a systems thinking perspective

Cluster Performance reconsidered: Structure, Linkages and Paths in the German Biotechnology Industry, 1996-2003

This paper addresses the evolution of biotechnology clusters in Germany between 1996 and 2003, paying particular attention to their respective composition in terms of venture capital, basic science institutions and biotechnology firms. Drawing upon the significance of co-location of "money and ideas", the literature stressing the importance of a cluster's openness and external linkages, and the path dependency debate, the paper aims to analyse how certain cluster characteristics correspond with its overall performance. After identifying different cluster types, we investigate their internal and external interconnectivity in comparative manner and draw on changes in cluster composition. Our results indicate that the structure, i.e. to which group the cluster belongs, and the openness towards external knowledge flows deliver merely unsystematic indications with regard to a cluster's overall success. Its ability to change composition towards a more balanced ratio of science and capital over time, on the other hand, turns out as a key explanatory factor. Hence, the dynamic perspective proves effective illuminating cluster growth and performance, where our explorative findings provide a promising avenue for further evolutionary research