Robust Individual Circadian Parameter Estimation for Biosignal-based Personalisation of Cancer Chronotherapy

In cancer treatment, chemotherapy is administered according a constant schedule. The chronotherapy approach, considering chronobiological drug delivery, adapts the chemotherapy profile to the circadian rhythms of the human organism. This reduces toxicity effects and at the same time enhances efficiency of chemotherapy. To personalize cancer treatment, chemotherapy profiles have to be further adapted to individual patients. Therefore, we present a new model to represent cycle phenomena in circadian rhythms. The model enables a more precise modelling of the underlying circadian rhythms. In comparison with the standard model, our model delivers better results in all defined quality indices. The new model can be used to adapt the chemotherapy profile efficiently to individual patients. The adaption to individual patients contributes to the aim of personalizing cancer therapy.Comment: Conference Biosig 2016, Berli

PULP-HD: Accelerating Brain-Inspired High-Dimensional Computing on a Parallel Ultra-Low Power Platform

Computing with high-dimensional (HD) vectors, also referred to as $\textit{hypervectors}$, is a brain-inspired alternative to computing with scalars. Key properties of HD computing include a well-defined set of arithmetic operations on hypervectors, generality, scalability, robustness, fast learning, and ubiquitous parallel operations. HD computing is about manipulating and comparing large patterns-binary hypervectors with 10,000 dimensions-making its efficient realization on minimalistic ultra-low-power platforms challenging. This paper describes HD computing's acceleration and its optimization of memory accesses and operations on a silicon prototype of the PULPv3 4-core platform (1.5mm$^2$, 2mW), surpassing the state-of-the-art classification accuracy (on average 92.4%) with simultaneous 3.7$\times$ end-to-end speed-up and 2$\times$ energy saving compared to its single-core execution. We further explore the scalability of our accelerator by increasing the number of inputs and classification window on a new generation of the PULP architecture featuring bit-manipulation instruction extensions and larger number of 8 cores. These together enable a near ideal speed-up of 18.4$\times$ compared to the single-core PULPv3

Prerequisites for Affective Signal Processing (ASP) - Part V: A response to comments and suggestions

In four papers, a set of eleven prerequisites for affective signal processing (ASP) were identified (van den Broek et al., 2010): validation, triangulation, a physiology-driven approach, contributions of the signal processing community, identification of users, theoretical specification, integration of biosignals, physical characteristics, historical perspective, temporal construction, and real-world baselines. Additionally, a review (in two parts) of affective computing was provided. Initiated by the reactions on these four papers, we now present: i) an extension of the review, ii) a post-hoc analysis based on the eleven prerequisites of Picard et al.(2001), and iii) a more detailed discussion and illustrations of temporal aspects with ASP

Classifying and Predicting Respiratory Function Based on Gait Analysis

The human walking behaviour can express the physiological information of human body, and gait analysis methods can be used to access the human body condition. In addition, the respiratory parameters from pulmonary spirometer are the standard of accessing the body condition of the subjects. Therefore, we want to show the correlation between gait analysis method and the respiratory parameters. We propose a vision sensor-based gait analysis method without wearing any sensors. Our method proposed features such as D′p, V′p and γυ to prove the correlation by classification and prediction experiment. In our experiment, the subjects are divided into three levels depending on the respiratory index. We run classifying and predicting experiment with the extracted features: V′p and γυ. In the classifying experiment, the accuracy result is 75%. In predicting experiment, the correlations of predicting the forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) are 0.69 and 0.67, respectively. Therefore, there is a correlation between the pulmonary spirometer and our method. The radar system is a tool using impulse to record the moving of the subjects’ chest. Combining the features of radar system with our features improves the classification result from 75 to 81%. In predicting FEV1/FVC, the correlation also improves from 25 to 42%. Therefore, cooperating with radar system improves the correlation

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Nonlinear Adaptive Signal Processing Improves the Diagnostic Quality of Transabdominal Fetal Electrocardiography

The abdominal fetal electrocardiogram (fECG) conveys valuable information that can aid clinicians with the diagnosis and monitoring of a potentially at risk fetus during pregnancy and in childbirth. This chapter primarily focuses on noninvasive (external and indirect) transabdominal fECG monitoring. Even though it is the preferred monitoring method, unlike its classical invasive (internal and direct) counterpart (transvaginal monitoring), it may be contaminated by a variety of undesirable signals that deteriorate its quality and reduce its value in reliable detection of hypoxic conditions in the fetus. A stronger maternal electrocardiogram (the mECG signal) along with technical and biological artifacts constitutes the main interfering signal components that diminish the diagnostic quality of the transabdominal fECG recordings. Currently, transabdominal fECG monitoring relies solely on the determination of the fetus’ pulse or heart rate (FHR) by detecting RR intervals and does not take into account the morphology and duration of the fECG waves (P, QRS, T), intervals, and segments, which collectively convey very useful diagnostic information in adult cardiology. The main reason for the exclusion of these valuable pieces of information in the determination of the fetus’ status from clinical practice is the fact that there are no sufficiently reliable and well-proven techniques for accurate extraction of fECG signals and robust derivation of these informative features. To address this shortcoming in fetal cardiology, we focus on adaptive signal processing methods and pay particular attention to nonlinear approaches that carry great promise in improving the quality of transabdominal fECG monitoring and consequently impacting fetal cardiology in clinical practice. Our investigation and experimental results by using clinical-quality synthetic data generated by our novel fECG signal generator suggest that adaptive neuro-fuzzy inference systems could produce a significant advancement in fetal monitoring during pregnancy and childbirth. The possibility of using a single device to leverage two advanced methods of fetal monitoring, namely noninvasive cardiotocography (CTG) and ST segment analysis (STAN) simultaneously, to detect fetal hypoxic conditions is very promising