15,266 research outputs found

    UMMS Biomedical Data Assets & D3Health

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    As part of the mini-symposium entitled “Research on Digital Health for Designing Scalable Pervasive Healthcare Monitoring, Rehabilitation, and Home-based Healthcare Systems,” Dr. Mathew discusses the research and clinical data ecosystem at UMass Medical School and the D3Health system integrating biomedical big data, analytics, and decision support

    Leveraging FAERS and Big Data Analytics with Machine Learning for Advanced Healthcare Solutions

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    This research study explores the potential of leveraging the FDA Adverse Event Reporting System (FAERS), combined with big data analytics and machine learning techniques, to enhance healthcare solutions. FAERS serves as a comprehensive database maintained by the U.S. Food and Drug Administration (FDA), encompassing reports of adverse events, medication errors, and product quality issues associated with diverse drugs and therapeutic interventions.By harnessing the power of big data analytics applied to the vast information within FAERS, healthcare professionals and researchers gain valuable insights into drug safety, discover potential adverse reactions, and uncover patterns that may not have been discernible through traditional methods. Particularly, machine learning plays a pivotal role in processing and analyzing this extensive dataset, enabling the extraction of meaningful patterns and prediction of adverse events.The findings of this study demonstrate various ways in which FAERS, big data analytics, and machine learning can be leveraged to provide advanced healthcare solutions. Machine learning algorithms trained on FAERS data can effectively identify early signals of adverse events associated with specific drugs or treatments, allowing for prompt detection and appropriate actions.Big data analytics applied to FAERS data facilitate pharmacovigilance and drug safety monitoring. Machine learning models automatically classify and analyze adverse event reports, efficiently flagging potential safety concerns and identifying emerging trends.The integration of FAERS data with big data analytics and machine learning enables signal detection and causality assessment. This approach aids in the identification of signals that suggest a causal relationship between drugs and adverse events, thereby enhancing the assessment of drug safety.By analyzing FAERS data in conjunction with patient-specific information, machine learning models can assist in identifying patient subgroups that are more susceptible to adverse events. This information is instrumental in personalizing treatment plans and optimizing medication choices, ultimately leading to improved patient outcomes.The combination of FAERS data with other biomedical information offers insights into potential new uses or indications for existing drugs. Machine learning algorithms analyze the integrated data, identifying patterns and making predictions about the efficacy and safety of repurposing existing drugs for new applications.The implementation of FAERS, big data analytics, and machine learning in advanced healthcare solutions necessitates meticulous consideration of data privacy, security, and ethical implications. Safeguarding patient privacy and ensuring responsible data use through anonymization techniques and appropriate data governance are paramount.The integration of FAERS, big data analytics, and machine learning holds immense potential in advancing healthcare solutions, enhancing patient safety, and optimizing medical interventions. The findings of this study demonstrate the multifaceted benefits that can be derived from leveraging these technologies, paving the way for a more efficient and effective healthcare ecosystem

    A Review on the Role of Nano-Communication in Future Healthcare Systems: A Big Data Analytics Perspective

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    This paper presents a first-time review of the open literature focused on the significance of big data generated within nano-sensors and nano-communication networks intended for future healthcare and biomedical applications. It is aimed towards the development of modern smart healthcare systems enabled with P4, i.e. predictive, preventive, personalized and participatory capabilities to perform diagnostics, monitoring, and treatment. The analytical capabilities that can be produced from the substantial amount of data gathered in such networks will aid in exploiting the practical intelligence and learning capabilities that could be further integrated with conventional medical and health data leading to more efficient decision making. We have also proposed a big data analytics framework for gathering intelligence, form the healthcare big data, required by futuristic smart healthcare to address relevant problems and exploit possible opportunities in future applications. Finally, the open challenges, future directions for researchers in the evolving healthcare domain, are presented

    Focus on: New trends, challenges and perspectives on healthcare cognitive computing: from information extraction to healthcare analytics

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    The focus of this special issue is cognitive computing in healthcare, due to the ever-increasing interest it is gaining for both research purposes and clinical applications. Indeed, cognitive computing is a challenging technology in many fields of application (Banavar, 2016) such as, e.g., medicine, education or eco- nomics (Coccoli et al., 2016) especially for the management of huge quantities of information where cognitive computing techniques push applications based on the use of big data (Coccoli et al., 2017). An unprecedented amount of data is made available from a heterogeneous variety of sources and this is true also in the case of health data, which can be exploited in many ways by means of sophisticated cognitive computing solutions and related technologies, such as, e.g., information extraction, natural language processing, and analytics. Also, from the point of view of programming they set challenging issues (see, e.g., Coccoli et al., 2015). In fact, the amount of healthcare that is now available and, potentially useful to care teams, reached 150 Exabytes worldwide and about 80% of this huge volume of data is in an unstructured form, being thus somehow invisible to systems. Hence, it is clear that cognitive computing and data analytics are the two key factors we have for make use – at least partially – of such a big volume of data. This can lead to personalized health solutions and healthcare systems that are more reliable, effective and efficient also re- ducing their expenditures. Healthcare will have a big impact on industry and research. However, this field, which seems to be a new era for our society, requires many scientific endeavours. Just to name a few, you need to create a hybrid and secure cloud to guarantee the security and confidentiality of health data, especially when smartphones or similar devices are used with specific app (see, e.g., Mazurczyk & Caviglione, 2015). Beside the cloud, you also need to consider novel ar- chitectures and data platforms that shall be different from the existing ones,because 90% of health and biomedical data are images and also because 80% of health data in the world is not available on the Web. This special issue wants to review state-of-the-art of issues and solutions of cognitive computing, focusing also on the current challenges and perspecti- ves and includes a heterogeneous collection of papers covering the following topics: information extraction in healthcare applications, semantic analysis in medicine, data analytics in healthcare, machine learning and cognitive com- puting, data architecture for healthcare, data platform for healthcare, hybrid cloud for healthcare

    Real-World Evidence Gathering in Oncology: The Need for a Biomedical Big Data Insight-Providing Federated Network

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    Moving toward new adaptive pathways for the development and access to innovative medicines implies that real-world data (RWD) collected throughout the medicinal product life cycle is becoming increasingly important. Big data analytics on RWD can obtain new and powerful insights into medicines' effectiveness. However, the healthcare ecosystem still faces many sector-specific challenges that hamper the use of big data analytics delivering real world evidence (RWE). We distinguish between exploratory (ExTE) and hypotheses-evaluating (HETE) studies testing treatment effectiveness in the real world. From our experience and in the context of the four V's of data management, we show that to get meaningful results data Variety and Veracity are needed regardless of the type of study conducted. More so, for ExTE studies high data Volume is needed while for HETE studies high Velocity becomes essential. Next, we highlight what are needed within the biomedical big data ecosystem, being: (a) international data reusability; (b) real-time RWD processing information systems; and (c) longitudinal RWD. Finally, in an effort to manage the four V's whilst respecting patient privacy laws we argue for the development of an underlying federated RWD infrastructure on a common data model, capable of bringing the centrally-conducted big data analysis to the de-centrally kept biomedical data

    Primer for Image Informatics in Personalized Medicine

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    AbstractImage informatics encompasses the concept of extracting and quantifying information contained in image data. Scenes, what an image contains, come from many imager devices such as consumer electronics, medical imaging systems, 3D laser scanners, microscopes, or satellites. There is a marked increase in image informatics applications as there have been simultaneous advances in imaging platforms, data availability due to social media, and big data analytics. An area ready to take advantage of these developments is personalized medicine, the concept where the goal is tailor healthcare to the individual. Patient health data is computationally profiled against a large of pool of feature-rich data from other patients to ideally optimize how a physician chooses care. One of the daunting challenges is how to effectively utilize medical image data in personalized medicine. Reliable data analytics products require as much automation as possible, which is a difficulty for data like histopathology and radiology images because we require highly trained expert physicians to interpret the information. This review targets biomedical scientists interested in getting started on tackling image analytics. We present high level discussions of sample preparation and image acquisition; data formats; storage and databases; image processing; computer vision and machine learning; and visualization and interactive programming. Examples will be covered using existing open-source software tools such as ImageJ, CellProfiler, and IPython Notebook. We discuss how difficult real-world challenges faced by image informatics and personalized medicine are being tackled with open-source biomedical data and software

    Data analytics based positioning of health informatics programs

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    The Master of Science in Computer Information Systems (CIS) with concentration in Health Informatics (HI) at Metropolitan College (MET), Boston University (BU), is a 40-credit degree program that are delivered in three formats: face-to-face, online, and blended. The MET CIS-HI program is unique because of the population of students it serves, namely those interested in gaining skills in HI technology field, to serve as data analysts and knowledge-based technology drivers in the thriving health care industry. This set of skills is essential for addressing the challenges of Big Data and knowledge-based health care support of the modern health care. The MET CIS-HI program was accredited by the Commission on Accreditation for Health Informatics and Information Management Education (CAHIIM) in 2017
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