16 research outputs found

    Methods to Improve Applicability and Efficiency of Distributed Data-Centric Compute Frameworks

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    The success of modern applications depends on the insights they collect from their data repositories. Data repositories for such applications currently exceed exabytes and are rapidly increasing in size, as they collect data from varied sources - web applications, mobile phones, sensors and other connected devices. Distributed storage and data-centric compute frameworks have been invented to store and analyze these large datasets. This dissertation focuses on extending the applicability and improving the efficiency of distributed data-centric compute frameworks

    2013 Doctoral Workshop on Distributed Systems

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    The Doctoral Workshop on Distributed Systems was held at Les Plans-sur-Bex, Switzerland, from June 26-28, 2013. Ph.D. students from the Universities of Neuchâtel and Bern as well as the University of Applied Sciences of Fribourg presented their current research work and discussed recent research results. This technical report includes the extended abstracts of the talks given during the workshop

    Matching distributed file systems with application workloads

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    Modern storage systems have a large number of configurable parameters, distributed over many layers of abstraction. The number of combinations of these parameters, that can be altered to create an instance of such a system, is enormous. In practise, many of these parameters are never altered; instead default values, intended to support generic workloads and access patterns, are used. As systems become larger and evolve to support different workloads, the appropriateness of using default parameters in this way comes into question. This thesis examines the implications of changing some of these parameters and explores the effects these changes have on performance. As part of that work multiple contributions have been made, including the creation of a structured method to create and evaluate different storage configurations, choosing appropriate access sizes for the evaluation, picking representative cloud workloads and capturing storage traces for further analysis, extraction of the workload storage characteristics, creating logical partitions of the distributed file system used for the optimization, the creation of heterogeneous storage pools within the homogeneous system and the mapping and evaluation of the chosen workloads to the examined configurations

    Evolutionary genomics : statistical and computational methods

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    This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward

    Evolutionary Genomics

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    This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital relationships between genotype and phenotype. After a few educational primers, the book continues with sections on sequence homology and alignment, phylogenetic methods to study genome evolution, methodologies for evaluating selective pressures on genomic sequences as well as genomic evolution in light of protein domain architecture and transposable elements, population genomics and other omics, and discussions of current bottlenecks in handling and analyzing genomic data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that lead to the best results. Authoritative and comprehensive, Evolutionary Genomics: Statistical and Computational Methods, Second Edition aims to serve both novices in biology with strong statistics and computational skills, and molecular biologists with a good grasp of standard mathematical concepts, in moving this important field of study forward
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