Distortion-constraint compression of three-dimensional CLSM images using image pyramid and vector quantization

The confocal microscopy imaging techniques, which allow optical sectioning, have been successfully exploited in biomedical studies. Biomedical scientists can benefit from more realistic visualization and much more accurate diagnosis by processing and analysing on a three-dimensional image data. The lack of efficient image compression standards makes such large volumetric image data slow to transfer over limited bandwidth networks. It also imposes large storage space requirements and high cost in archiving and maintenance. Conventional two-dimensional image coders do not take into account inter-frame correlations in three-dimensional image data. The standard multi-frame coders, like video coders, although they have good performance in capturing motion information, are not efficiently designed for coding multiple frames representing a stack of optical planes of a real object. Therefore a real three-dimensional image compression approach should be investigated. Moreover the reconstructed image quality is a very important concern in compressing medical images, because it could be directly related to the diagnosis accuracy. Most of the state-of-the-arts methods are based on transform coding, for instance JPEG is based on discrete-cosine-transform CDCT) and JPEG2000 is based on discrete- wavelet-transform (DWT). However in DCT and DWT methods, the control of the reconstructed image quality is inconvenient, involving considerable costs in computation, since they are fundamentally rate-parameterized methods rather than distortion-parameterized methods. Therefore it is very desirable to develop a transform-based distortion-parameterized compression method, which is expected to have high coding performance and also able to conveniently and accurately control the final distortion according to the user specified quality requirement. This thesis describes our work in developing a distortion-constraint three-dimensional image compression approach, using vector quantization techniques combined with image pyramid structures. We are expecting our method to have: 1. High coding performance in compressing three-dimensional microscopic image data, compared to the state-of-the-art three-dimensional image coders and other standardized two-dimensional image coders and video coders. 2. Distortion-control capability, which is a very desirable feature in medical 2. Distortion-control capability, which is a very desirable feature in medical image compression applications, is superior to the rate-parameterized methods in achieving a user specified quality requirement. The result is a three-dimensional image compression method, which has outstanding compression performance, measured objectively, for volumetric microscopic images. The distortion-constraint feature, by which users can expect to achieve a target image quality rather than the compressed file size, offers more flexible control of the reconstructed image quality than its rate-constraint counterparts in medical image applications. Additionally, it effectively reduces the artifacts presented in other approaches at low bit rates and also attenuates noise in the pre-compressed images. Furthermore, its advantages in progressive transmission and fast decoding make it suitable for bandwidth limited tele-communications and web-based image browsing applications

Recent Advances in Signal Processing

The signal processing task is a very critical issue in the majority of new technological inventions and challenges in a variety of applications in both science and engineering fields. Classical signal processing techniques have largely worked with mathematical models that are linear, local, stationary, and Gaussian. They have always favored closed-form tractability over real-world accuracy. These constraints were imposed by the lack of powerful computing tools. During the last few decades, signal processing theories, developments, and applications have matured rapidly and now include tools from many areas of mathematics, computer science, physics, and engineering. This book is targeted primarily toward both students and researchers who want to be exposed to a wide variety of signal processing techniques and algorithms. It includes 27 chapters that can be categorized into five different areas depending on the application at hand. These five categories are ordered to address image processing, speech processing, communication systems, time-series analysis, and educational packages respectively. The book has the advantage of providing a collection of applications that are completely independent and self-contained; thus, the interested reader can choose any chapter and skip to another without losing continuity

Robust density modelling using the student's t-distribution for human action recognition

The extraction of human features from videos is often inaccurate and prone to outliers. Such outliers can severely affect density modelling when the Gaussian distribution is used as the model since it is highly sensitive to outliers. The Gaussian distribution is also often used as base component of graphical models for recognising human actions in the videos (hidden Markov model and others) and the presence of outliers can significantly affect the recognition accuracy. In contrast, the Student's t-distribution is more robust to outliers and can be exploited to improve the recognition rate in the presence of abnormal data. In this paper, we present an HMM which uses mixtures of t-distributions as observation probabilities and show how experiments over two well-known datasets (Weizmann, MuHAVi) reported a remarkable improvement in classification accuracy. © 2011 IEEE

Compression of Three-Dimensional Magnetic Resonance Brain Images.

Losslessly compressing a medical image set with multiple slices is paramount in radiology since all the information within a medical image set is crucial for both diagnosis and treatment. This dissertation presents a novel and efficient diagnostically lossless compression scheme (predicted wavelet lossless compression method) for sets of magnetic resonance (MR) brain images, which are called 3-D MR brain images. This compression scheme provides 3-D MR brain images with the progressive and preliminary diagnosis capabilities. The spatial dependency in 3-D MR brain images is studied with histograms, entropy, correlation, and wavelet decomposition coefficients. This spatial dependency is utilized to design three kinds of predictors, i.e., intra-, inter-, and intra-and-inter-slice predictors, that use the correlation among neighboring pixels. Five integer wavelet transformations are applied to the prediction residues. It shows that the intra-slice predictor 3 using a x-pixel and a y-pixel for prediction plus the 1st-level (2, 2) interpolating integer wavelet with run-length and arithmetic coding achieves the best compression. An automated threshold based background noise removal technique is applied to remove the noise outside the diagnostic region. This preprocessing method improves the compression ratio of the proposed compression technique by approximately 1.61 times. A feature vector based approach is used to determine the representative slice with the most discernible brain structures. This representative slice is progressively encoded by a lossless embedded zerotree wavelet method. A rough version of this representative slice is gradually transmitted at an increasing bit rate so the validity of the whole set can be determined early. This feature vector based approach is also utilized to detect multiple sclerosis (MS) at an early stage. Our compression technique with the progressive and preliminary diagnosis capability is tested with simulated and real 3-D MR brain image sets. The compression improvement versus the best commonly used lossless compression method (lossless JPEG) is 41.83% for simulated 3-D MR brain image sets and 71.42% for real 3-D MR brain image sets. The accuracy of the preliminary MS diagnosis is 66.67% based on six studies with an expert radiologist\u27s diagnosis

Efficient reconfigurable architectures for 3D medical image compression

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Recently, the more widespread use of three-dimensional (3-D) imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound (US) have generated a massive amount of volumetric data. These have provided an impetus to the development of other applications, in particular telemedicine and teleradiology. In these fields, medical image compression is important since both efficient storage and transmission of data through high-bandwidth digital communication lines are of crucial importance. Despite their advantages, most 3-D medical imaging algorithms are computationally intensive with matrix transformation as the most fundamental operation involved in the transform-based methods. Therefore, there is a real need for high-performance systems, whilst keeping architectures exible to allow for quick upgradeability with real-time applications. Moreover, in order to obtain efficient solutions for large medical volumes data, an efficient implementation of these operations is of significant importance. Reconfigurable hardware, in the form of field programmable gate arrays (FPGAs) has been proposed as viable system building block in the construction of high-performance systems at an economical price. Consequently, FPGAs seem an ideal candidate to harness and exploit their inherent advantages such as massive parallelism capabilities, multimillion gate counts, and special low-power packages. The key achievements of the work presented in this thesis are summarised as follows. Two architectures for 3-D Haar wavelet transform (HWT) have been proposed based on transpose-based computation and partial reconfiguration suitable for 3-D medical imaging applications. These applications require continuous hardware servicing, and as a result dynamic partial reconfiguration (DPR) has been introduced. Comparative study for both non-partial and partial reconfiguration implementation has shown that DPR offers many advantages and leads to a compelling solution for implementing computationally intensive applications such as 3-D medical image compression. Using DPR, several large systems are mapped to small hardware resources, and the area, power consumption as well as maximum frequency are optimised and improved. Moreover, an FPGA-based architecture of the finite Radon transform (FRAT)with three design strategies has been proposed: direct implementation of pseudo-code with a sequential or pipelined description, and block random access memory (BRAM)- based method. An analysis with various medical imaging modalities has been carried out. Results obtained for image de-noising implementation using FRAT exhibits promising results in reducing Gaussian white noise in medical images. In terms of hardware implementation, promising trade-offs on maximum frequency, throughput and area are also achieved. Furthermore, a novel hardware implementation of 3-D medical image compression system with context-based adaptive variable length coding (CAVLC) has been proposed. An evaluation of the 3-D integer transform (IT) and the discrete wavelet transform (DWT) with lifting scheme (LS) for transform blocks reveal that 3-D IT demonstrates better computational complexity than the 3-D DWT, whilst the 3-D DWT with LS exhibits a lossless compression that is significantly useful for medical image compression. Additionally, an architecture of CAVLC that is capable of compressing high-definition (HD) images in real-time without any buffer between the quantiser and the entropy coder is proposed. Through a judicious parallelisation, promising results have been obtained with limited resources. In summary, this research is tackling the issues of massive 3-D medical volumes data that requires compression as well as hardware implementation to accelerate the slowest operations in the system. Results obtained also reveal a significant achievement in terms of the architecture efficiency and applications performance.Ministry of Higher Education Malaysia (MOHE), Universiti Tun Hussein Onn Malaysia (UTHM) and the British Counci

Compression of 4D medical image and spatial segmentation using deformable models

Ph.DDOCTOR OF PHILOSOPH

Digital Image Processing

This book presents several recent advances that are related or fall under the umbrella of 'digital image processing', with the purpose of providing an insight into the possibilities offered by digital image processing algorithms in various fields. The presented mathematical algorithms are accompanied by graphical representations and illustrative examples for an enhanced readability. The chapters are written in a manner that allows even a reader with basic experience and knowledge in the digital image processing field to properly understand the presented algorithms. Concurrently, the structure of the information in this book is such that fellow scientists will be able to use it to push the development of the presented subjects even further

Artificial Intelligence in the Creative Industries: A Review

This paper reviews the current state of the art in Artificial Intelligence (AI) technologies and applications in the context of the creative industries. A brief background of AI, and specifically Machine Learning (ML) algorithms, is provided including Convolutional Neural Network (CNNs), Generative Adversarial Networks (GANs), Recurrent Neural Networks (RNNs) and Deep Reinforcement Learning (DRL). We categorise creative applications into five groups related to how AI technologies are used: i) content creation, ii) information analysis, iii) content enhancement and post production workflows, iv) information extraction and enhancement, and v) data compression. We critically examine the successes and limitations of this rapidly advancing technology in each of these areas. We further differentiate between the use of AI as a creative tool and its potential as a creator in its own right. We foresee that, in the near future, machine learning-based AI will be adopted widely as a tool or collaborative assistant for creativity. In contrast, we observe that the successes of machine learning in domains with fewer constraints, where AI is the `creator', remain modest. The potential of AI (or its developers) to win awards for its original creations in competition with human creatives is also limited, based on contemporary technologies. We therefore conclude that, in the context of creative industries, maximum benefit from AI will be derived where its focus is human centric -- where it is designed to augment, rather than replace, human creativity