Process Mining of Programmable Logic Controllers: Input/Output Event Logs

This paper presents an approach to model an unknown Ladder Logic based Programmable Logic Controller (PLC) program consisting of Boolean logic and counters using Process Mining techniques. First, we tap the inputs and outputs of a PLC to create a data flow log. Second, we propose a method to translate the obtained data flow log to an event log suitable for Process Mining. In a third step, we propose a hybrid Petri net (PN) and neural network approach to approximate the logic of the actual underlying PLC program. We demonstrate the applicability of our proposed approach on a case study with three simulated scenarios

The computer revolution in science: steps towards the realization of computer-supported discovery environments

The tools that scientists use in their search processes together form so-called discovery environments. The promise of artificial intelligence and other branches of computer science is to radically transform conventional discovery environments by equipping scientists with a range of powerful computer tools including large-scale, shared knowledge bases and discovery programs. We will describe the future computer-supported discovery environments that may result, and illustrate by means of a realistic scenario how scientists come to new discoveries in these environments. In order to make the step from the current generation of discovery tools to computer-supported discovery environments like the one presented in the scenario, developers should realize that such environments are large-scale sociotechnical systems. They should not just focus on isolated computer programs, but also pay attention to the question how these programs will be used and maintained by scientists in research practices. In order to help developers of discovery programs in achieving the integration of their tools in discovery environments, we will formulate a set of guidelines that developers could follow

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.

The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase. Serendipitously, we also found that several predicted farnesyl diphosphate synthase inhibitors were low-micromolar inhibitors of undecaprenyl diphosphate synthase. These results are of interest because farnesyl diphosphate synthase inhibitors are being pursued as both anti-infective and anticancer agents, and undecaprenyl diphosphate synthase inhibitors are antibacterial drug leads

Automated verification of refinement laws

Demonic refinement algebras are variants of Kleene algebras. Introduced by von Wright as a light-weight variant of the refinement calculus, their intended semantics are positively disjunctive predicate transformers, and their calculus is entirely within first-order equational logic. So, for the first time, off-the-shelf automated theorem proving (ATP) becomes available for refinement proofs. We used ATP to verify a toolkit of basic refinement laws. Based on this toolkit, we then verified two classical complex refinement laws for action systems by ATP: a data refinement law and Back's atomicity refinement law. We also present a refinement law for infinite loops that has been discovered through automated analysis. Our proof experiments not only demonstrate that refinement can effectively be automated, they also compare eleven different ATP systems and suggest that program verification with variants of Kleene algebras yields interesting theorem proving benchmarks. Finally, we apply hypothesis learning techniques that seem indispensable for automating more complex proofs