Automatic Autism Spectrum Disorder Detection Using Artificial Intelligence Methods with MRI Neuroimaging: A Review

Autism spectrum disorder (ASD) is a brain condition characterized by diverse signs and symptoms that appear in early childhood. ASD is also associated with communication deficits and repetitive behavior in affected individuals. Various ASD detection methods have been developed, including neuroimaging modalities and psychological tests. Among these methods, magnetic resonance imaging (MRI) imaging modalities are of paramount importance to physicians. Clinicians rely on MRI modalities to diagnose ASD accurately. The MRI modalities are non-invasive methods that include functional (fMRI) and structural (sMRI) neuroimaging methods. However, the process of diagnosing ASD with fMRI and sMRI for specialists is often laborious and time-consuming; therefore, several computer-aided design systems (CADS) based on artificial intelligence (AI) have been developed to assist the specialist physicians. Conventional machine learning (ML) and deep learning (DL) are the most popular schemes of AI used for diagnosing ASD. This study aims to review the automated detection of ASD using AI. We review several CADS that have been developed using ML techniques for the automated diagnosis of ASD using MRI modalities. There has been very limited work on the use of DL techniques to develop automated diagnostic models for ASD. A summary of the studies developed using DL is provided in the appendix. Then, the challenges encountered during the automated diagnosis of ASD using MRI and AI techniques are described in detail. Additionally, a graphical comparison of studies using ML and DL to diagnose ASD automatically is discussed. We conclude by suggesting future approaches to detecting ASDs using AI techniques and MRI neuroimaging

Face Image and Video Analysis in Biometrics and Health Applications

Computer Vision (CV) enables computers and systems to derive meaningful information from acquired visual inputs, such as images and videos, and make decisions based on the extracted information. Its goal is to acquire, process, analyze, and understand the information by developing a theoretical and algorithmic model. Biometrics are distinctive and measurable human characteristics used to label or describe individuals by combining computer vision with knowledge of human physiology (e.g., face, iris, fingerprint) and behavior (e.g., gait, gaze, voice). Face is one of the most informative biometric traits. Many studies have investigated the human face from the perspectives of various different disciplines, ranging from computer vision, deep learning, to neuroscience and biometrics. In this work, we analyze the face characteristics from digital images and videos in the areas of morphing attack and defense, and autism diagnosis. For face morphing attacks generation, we proposed a transformer based generative adversarial network to generate more visually realistic morphing attacks by combining different losses, such as face matching distance, facial landmark based loss, perceptual loss and pixel-wise mean square error. In face morphing attack detection study, we designed a fusion-based few-shot learning (FSL) method to learn discriminative features from face images for few-shot morphing attack detection (FS-MAD), and extend the current binary detection into multiclass classification, namely, few-shot morphing attack fingerprinting (FS-MAF). In the autism diagnosis study, we developed a discriminative few shot learning method to analyze hour-long video data and explored the fusion of facial dynamics for facial trait classification of autism spectrum disorder (ASD) in three severity levels. The results show outstanding performance of the proposed fusion-based few-shot framework on the dataset. Besides, we further explored the possibility of performing face micro- expression spotting and feature analysis on autism video data to classify ASD and control groups. The results indicate the effectiveness of subtle facial expression changes on autism diagnosis

A Deep Probabilistic Spatiotemporal Framework for Dynamic Graph Representation Learning with Application to Brain Disorder Identification

Recent applications of pattern recognition techniques on brain connectome classification using functional connectivity (FC) neglect the non-Euclidean topology and causal dynamics of brain connectivity across time. In this paper, a deep probabilistic spatiotemporal framework developed based on variational Bayes (DSVB) is proposed to learn time-varying topological structures in dynamic brain FC networks for autism spectrum disorder (ASD) identification. The proposed framework incorporates a spatial-aware recurrent neural network to capture rich spatiotemporal patterns across dynamic FC networks, followed by a fully-connected neural network to exploit these learned patterns for subject-level classification. To overcome model overfitting on limited training datasets, an adversarial training strategy is introduced to learn graph embedding models that generalize well to unseen brain networks. Evaluation on the ABIDE resting-state functional magnetic resonance imaging dataset shows that our proposed framework significantly outperformed state-of-the-art methods in identifying ASD. Dynamic FC analyses with DSVB learned embeddings reveal apparent group difference between ASD and healthy controls in network profiles and switching dynamics of brain states

Automatic autism spectrum disorder detection using artificial intelligence methods with MRI neuroimaging: A review

Autism spectrum disorder (ASD) is a brain condition characterized by diverse signs and symptoms that appear in early childhood. ASD is also associated with communication deficits and repetitive behavior in affected individuals. Various ASD detection methods have been developed, including neuroimaging modalities and psychological tests. Among these methods, magnetic resonance imaging (MRI) imaging modalities are of paramount importance to physicians. Clinicians rely on MRI modalities to diagnose ASD accurately. The MRI modalities are non-invasive methods that include functional (fMRI) and structural (sMRI) neuroimaging methods. However, diagnosing ASD with fMRI and sMRI for specialists is often laborious and time-consuming; therefore, several computer-aided design systems (CADS) based on artificial intelligence (AI) have been developed to assist specialist physicians. Conventional machine learning (ML) and deep learning (DL) are the most popular schemes of AI used for diagnosing ASD. This study aims to review the automated detection of ASD using AI. We review several CADS that have been developed using ML techniques for the automated diagnosis of ASD using MRI modalities. There has been very limited work on the use of DL techniques to develop automated diagnostic models for ASD. A summary of the studies developed using DL is provided in the Supplementary Appendix. Then, the challenges encountered during the automated diagnosis of ASD using MRI and AI techniques are described in detail. Additionally, a graphical comparison of studies using ML and DL to diagnose ASD automatically is discussed. We suggest future approaches to detecting ASDs using AI techniques and MRI neuroimaging.Qatar National Librar

Exploring the perceived challenges of single mothers with children diagnosed with autism disorder in the junior phase at Vera School

This study aimed to explore the perceived challenges of single mothers with children diagnosed with Autism who are in the junior phase at Vera School, focussing on key struggles which they face in caring for their children. Emphasis was on parental stresses during their children's diagnostic processes as well as lack of availability and accessibility of resources about Autism Spectrum Disorder. A qualitative research design was used to carry out the research, and purposive sampling was utilised to select the sample for this study. The sample comprised of 15 single mothers. A semi-structured interview schedule and a voice recorder were used to conduct the interviews. The research was conducted at Vera School, Rondebosch in Cape Town. Findings were drawn from the responses of the participants and compared with literature from previous studies. These findings indicated that single mothers of children diagnosed with Autism lack support to cope with the demands of caring for their children. This was highlighted in the early stages of assessment, making a diagnosis, and during early intervention of their children in a special needs school. Multiple roles, financial constraints and stigma were primary sources of parental stress, as pointed out in this study. Limited resources such as long waiting lists for admissions at special schools and aftercare facilities were highlighted as a great need

Contributions to the study of Austism Spectrum Brain conectivity

164 p.Autism Spectrum Disorder (ASD) is a largely prevalent neurodevelopmental condition with a big social and economical impact affecting the entire life of families. There is an intense search for biomarkers that can be assessed as early as possible in order to initiate treatment and preparation of the family to deal with the challenges imposed by the condition. Brain imaging biomarkers have special interest. Specifically, functional connectivity data extracted from resting state functional magnetic resonance imaging (rs-fMRI) should allow to detect brain connectivity alterations. Machine learning pipelines encompass the estimation of the functional connectivity matrix from brain parcellations, feature extraction and building classification models for ASD prediction. The works reported in the literature are very heterogeneous from the computational and methodological point of view. In this Thesis we carry out a comprehensive computational exploration of the impact of the choices involved while building these machine learning pipelines

Deep learning systems for estimating visual attention in robot-assisted therapy of children with autism and intellectual disability

Recent studies suggest that some children with autism prefer robots as tutors for improving their social interaction and communication abilities which are impaired due to their disorder. Indeed, research has focused on developing a very promising form of intervention named Robot-Assisted Therapy. This area of intervention poses many challenges, including the necessary flexibility and adaptability to real unconstrained therapeutic settings, which are different from the constrained lab settings where most of the technology is typically tested. Among the most common impairments of children with autism and intellectual disability is social attention, which includes difficulties in establishing the correct visual focus of attention. This article presents an investigation on the use of novel deep learning neural network architectures for automatically estimating if the child is focusing their visual attention on the robot during a therapy session, which is an indicator of their engagement. To study the application, the authors gathered data from a clinical experiment in an unconstrained setting, which provided low-resolution videos recorded by the robot camera during the child–robot interaction. Two deep learning approaches are implemented in several variants and compared with a standard algorithm for face detection to verify the feasibility of estimating the status of the child directly from the robot sensors without relying on bulky external settings, which can distress the child with autism. One of the proposed approaches demonstrated a very high accuracy and it can be used for off-line continuous assessment during the therapy or for autonomously adapting the intervention in future robots with better computational capabilities

EEG Connectivity Analysis Using Denoising Autoencoders for the Detection of Dyslexia

The Temporal Sampling Framework (TSF) theorizes that the characteristic phonological difficulties of dyslexia are caused by an atypical oscillatory sampling at one or more temporal rates. The LEEDUCA study conducted a series of Electroencephalography (EEG) experiments on children listening to amplitude modulated (AM) noise with slow-rythmic prosodic (0.5–1Hz), syllabic (4–8Hz) or the phoneme (12–40Hz) rates, aimed at detecting differences in perception of oscillatory sampling that could be associated with dyslexia. The purpose of this work is to check whether these differences exist and how they are related to children’s performance in different language and cognitive tasks commonly used to detect dyslexia. To this purpose, temporal and spectral inter-channel EEG connectivity was estimated, and a denoising autoencoder (DAE) was trained to learn a low-dimensional representation of the connectivity matrices. This representation was studied via correlation and classification analysis, which revealed ability in detecting dyslexic subjects with an accuracy higher than 0.8, and balanced accuracy around 0.7. Some features of the DAE representation were significantly correlated (�<0.005 ) with children’s performance in language and cognitive tasks of the phonological hypothesis category such as phonological awareness and rapid symbolic naming, as well as reading efficiency and reading comprehension. Finally, a deeper analysis of the adjacency matrix revealed a reduced bilateral connection between electrodes of the temporal lobe (roughly the primary auditory cortex) in DD subjects, as well as an increased connectivity of the F7 electrode, placed roughly on Broca’s area. These results pave the way for a complementary assessment of dyslexia using more objective methodologies such as EEG

Neuropsychiatric Disease Classification Using Functional Connectomics - Results of the Connectomics in NeuroImaging Transfer Learning Challenge

Large, open-source datasets, such as the Human Connectome Project and the Autism Brain Imaging Data Exchange, have spurred the development of new and increasingly powerful machine learning approaches for brain connectomics. However, one key question remains: are we capturing biologically relevant and generalizable information about the brain, or are we simply overfitting to the data? To answer this, we organized a scientific challenge, the Connectomics in NeuroImaging Transfer Learning Challenge (CNI-TLC), held in conjunction with MICCAI 2019. CNI-TLC included two classification tasks: (1) diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD) within a pre-adolescent cohort; and (2) transference of the ADHD model to a related cohort of Autism Spectrum Disorder (ASD) patients with an ADHD comorbidity. In total, 240 resting-state fMRI (rsfMRI) time series averaged according to three standard parcellation atlases, along with clinical diagnosis, were released for training and validation (120 neurotypical controls and 120 ADHD). We also provided Challenge participants with demographic information of age, sex, IQ, and handedness. The second set of 100 subjects (50 neurotypical controls, 25 ADHD, and 25 ASD with ADHD comorbidity) was used for testing. Classification methodologies were submitted in a standardized format as containerized Docker images through ChRIS, an open-source image analysis platform. Utilizing an inclusive approach, we ranked the methods based on 16 metrics: accuracy, area under the curve, F1-score, false discovery rate, false negative rate, false omission rate, false positive rate, geometric mean, informedness, markedness, Matthew’s correlation coefficient, negative predictive value, optimized precision, precision, sensitivity, and specificity. The final rank was calculated using the rank product for each participant across all measures. Furthermore, we assessed the calibration curves of each methodology. Five participants submitted their method for evaluation, with one outperforming all other methods in both ADHD and ASD classification. However, further improvements are still needed to reach the clinical translation of functional connectomics. We have kept the CNI-TLC open as a publicly available resource for developing and validating new classification methodologies in the field of connectomics