18,351 research outputs found
Meta-models for structural reliability and uncertainty quantification
A meta-model (or a surrogate model) is the modern name for what was
traditionally called a response surface. It is intended to mimic the behaviour
of a computational model M (e.g. a finite element model in mechanics) while
being inexpensive to evaluate, in contrast to the original model which may take
hours or even days of computer processing time. In this paper various types of
meta-models that have been used in the last decade in the context of structural
reliability are reviewed. More specifically classical polynomial response
surfaces, polynomial chaos expansions and kriging are addressed. It is shown
how the need for error estimates and adaptivity in their construction has
brought this type of approaches to a high level of efficiency. A new technique
that solves the problem of the potential biasedness in the estimation of a
probability of failure through the use of meta-models is finally presented.Comment: Keynote lecture Fifth Asian-Pacific Symposium on Structural
Reliability and its Applications (5th APSSRA) May 2012, Singapor
Atomic radius and charge parameter uncertainty in biomolecular solvation energy calculations
Atomic radii and charges are two major parameters used in implicit solvent
electrostatics and energy calculations. The optimization problem for charges
and radii is under-determined, leading to uncertainty in the values of these
parameters and in the results of solvation energy calculations using these
parameters. This paper presents a new method for quantifying this uncertainty
in implicit solvation calculations of small molecules using surrogate models
based on generalized polynomial chaos (gPC) expansions. There are relatively
few atom types used to specify radii parameters in implicit solvation
calculations; therefore, surrogate models for these low-dimensional spaces
could be constructed using least-squares fitting. However, there are many more
types of atomic charges; therefore, construction of surrogate models for the
charge parameter space requires compressed sensing combined with an iterative
rotation method to enhance problem sparsity. We demonstrate the application of
the method by presenting results for the uncertainties in small molecule
solvation energies based on these approaches. The method presented in this
paper is a promising approach for efficiently quantifying uncertainty in a wide
range of force field parameterization problems, including those beyond
continuum solvation calculations.The intent of this study is to provide a way
for developers of implicit solvent model parameter sets to understand the
sensitivity of their target properties (solvation energy) on underlying choices
for solute radius and charge parameters
Variable-free exploration of stochastic models: a gene regulatory network example
Finding coarse-grained, low-dimensional descriptions is an important task in
the analysis of complex, stochastic models of gene regulatory networks. This
task involves (a) identifying observables that best describe the state of these
complex systems and (b) characterizing the dynamics of the observables. In a
previous paper [13], we assumed that good observables were known a priori, and
presented an equation-free approach to approximate coarse-grained quantities
(i.e, effective drift and diffusion coefficients) that characterize the
long-time behavior of the observables. Here we use diffusion maps [9] to
extract appropriate observables ("reduction coordinates") in an automated
fashion; these involve the leading eigenvectors of a weighted Laplacian on a
graph constructed from network simulation data. We present lifting and
restriction procedures for translating between physical variables and these
data-based observables. These procedures allow us to perform equation-free
coarse-grained, computations characterizing the long-term dynamics through the
design and processing of short bursts of stochastic simulation initialized at
appropriate values of the data-based observables.Comment: 26 pages, 9 figure
Reliability assessment of cutting tool life based on surrogate approximation methods
A novel reliability estimation approach to the cutting tools based on advanced approximation methods is proposed. Methods such as the stochastic response surface and surrogate modeling are tested, starting from a few sample points obtained through fundamental experiments and extending them to models able to estimate the tool wear as a function of the key process parameters. Subsequently, different reliability analysis methods are employed such as Monte Carlo simulations and first- and second-order reliability methods. In the present study, these reliability analysis methods are assessed for estimating the reliability of cutting tools. The results show that the proposed method is an efficient method for assessing the reliability of the cutting tool based on the minimum number of experimental results. Experimental verification for the case of high-speed turning confirms the findings of the present study for cutting tools under flank wear
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