Anti-Inflammatory Activity of Para Methoxy Cinnamic Acid (PMCA) In Nanoemulsion Using Soybean Oil

Inflammation is a protective mechanism of the local microcirculation to tissue injuries caused by physical trauma, stimulation by hazardous chemicals, heat, antigen-antibody reaction and the effect of microbial.[2] It is known to be involved in the inflammatory reactions such as release of histamine, bradykinin, prostaglandins, fluid cell migration, extravasations, tissue break down and repair which are aimed at host defense and usually activated in most disease conditions. Para methoxy cinnamic acid (PMCA) known has topical anti-inflammatory effect but only 0.64 compare with Na-diclophenac.[4] its cause PMCA is a poorly soluble drug substance (BCS II), the solubility in acetate buffer pH 4.2 ± 0.2 was 70.04 ± 0.66 mg/liter.[3] So in this study to increase the solubility PMCA loaded in nanoemulsion using soybean oil. And then the anti-inflammatory activity of PMCA in nanoemulsion was measured by the release rate, penetration rate through rat skin using Franz diffusion cell and histological test on mice's ear skin

Design of novel drug delivery system and optimal dosage regimens

Three representative drug delivery systems were analyzed to emphasize the roles of mathematical models and computer-aided simulations in pharmaceutical research. In the first project, a protocol was developed so that the optimal regimen, consisting of the intravenous boluses and subsequent infusion of theophylline, could be obtained once information on the pharmacokinetics became available. The method was based on a two-compartment model of the human body. A module was created and posted on a website for free access. The second project dealt with the transdermal heat-assisted delivery of corticosterone. Heat conduction and drug diffusion through the patch and the skin were expressed in the mathematical model. Four design parameters were estimated. This model was validated using clinical data from the administration of fentanyl. Cortisone concentrations through the patch and skin layers were predicted. The results were used to rank the relative impacts of the design parameters on the corticosterone delivery and to make proper suggestions for fabricating the products. Finally, the simultaneous application of an electric current and soluble microneedles were proposed for the first time. Preliminary experimental studies suggested that the electric field enhanced the flux by increasing drug diffusion and, thereby, the dissolution of the microneedles. One-, two- and three-dimensional simulations were conducted. In addition, protocols were proposed to help with the analysis of laboratory data

Modelling transdermal drug delivery using microneedles: effect of geometry on drug transport behaviour

Transdermal drug delivery using microneedles (MNs) depends on the rate of drug transport through the viable epidermis. Therefore, minimising the distance between the drug-loaded surface and the microcirculation in the dermis where the drug is absorbed into the body is significant in improving drug delivery efficiency. A quantifiable relationship between MN design parameters and skin diffusion properties is therefore desirable, which is what this study aims to achieve. A framework is presented to quantitatively determine the effects of design parameters on drug diffusion through skin, where the effects of compressive strain on skin due to insertion of MN are considered. The model is then used to analyse scenarios of practical importance. For all scenarios analysed, predicted steady-state flux was found to be lower when effect of MN strain on diffusion coefficient was accounted for. For example, simulations results indicated increasing tip radius from 5 to 20 μm and flux increased from 6.56 × 10 to 7.02 × 10 mol/(m s) for constant diffusion coefficient. However, if the effect of strain on diffusion coefficient is considered, the calculated flux increases from 5.30 × 10 to a peak value of 5.32 × 10 mol/(m s) (at 10 μm) and decreases to 5.29 × 10 mol/(m s). This paper contributes by reporting a framework to relate MN geometry to permeability with inclusion of the possible effects the MN design may pose on the diffusion coefficient. © 2011 Wiley Periodicals, Inc. and the American Pharmacists Association

Pameran Reka Cipta, Penyelidikan dan Inovasi (PRPI) 2009

PRPI 2009 kini telah memasuki tahun penganjurannya yang ke-7. Pameran penyelidikan di UPM telah bermula sejak tahun 1997 semasa Exhibition & Seminar Harnessing for Industry Advantage. Pada tahun 2002, Pameran Reka Cipta dan Penyelidikan (PRP) buat pertama kali telah diadakan dengan menggunakan konsep pertandingan hasil projek penyelidikan yang telah dijalankan oleh para penyelidik UPM. Kejayaan penganjuran PRP 2002 telah merintis usaha untuk menjadikannya sebagai aktiviti tahunan UPM dan ianya terus berkembang sejajar dengan nama baharunya yang ditukar kepada Pameran Reka Cipta, Penyelidikan dan Inovasi yang bermula penganjurannya pada tahun 2005. Sebagai kesinambungan daripada kejayaan penganjuran PRPI 2006, 2007 dan 2008 yang lalu dan status UPM sebagai salah sebuah Universiti Penyelidikan, PRPI 2009 kali ini yang merupakan pameran penyelidikan yang terbesar di UPM terus dilaksanakan dengan aspirasi dan semangat yang lebih jitu. Pameran ini juga menjadi pelantar kepada para penyelidik untuk mengenengahkan hasil penyelidikan yang dijalankan dan penemuan baharu kepada umum. Di samping itu ianya juga menjadi penanda aras terhadap kualiti sesuatu projek penyelidikan bagi melayakkan para penyelidik UPM untuk menyertai pameran di peringkat kebangsaan dan seterusnya antarabangsa. Adalah diharapkan pelaksanaan PRPI 2009 ini akan dapat menyemarakkan budaya penyelidikan di kalangan staf dan juga pelajar UPM sekaligus menjadikan UPM sebagai Universiti Penyelidikan yang cemerlang di negara ini

New approaches to scaled-up carbon nanotube synthesis and nanotube-based metal composites and sensors

The first phase of the work presented in this dissertation is the development of a scaleable process for the cost-effective synthesis of single walled carbon nanotubes (SWNTs) by thermally-induced catalytic chemical vapor deposition (CVD). With the goal of understanding the growth mechanism and optimize the synthesis process, the effect of CVD and catalyst parameters on nanotube formation was investigated in detail. It was found that nucleation and growth of SWNTs occurred within a few seconds of the introduction of the carbon source, carbon monoxide, at temperatures above 675°C over a Co-Mo/MgO catalyst/support system, resulting in the formation of high quality thinly bundled SWNTs with a narrow individual nanotube diameter distribution. A simple kinetic model is proposed to explain the observed growth and exit gas (CO2) concentration data. A scaled up run using fluidized bed reactor is performed to demonstrate large SWNTs production. In the second phase of the research performed some of the CVD parameters optimized for the synthesis of pure nanotubes were used to infiltrate SWNTs as well as multiwalled carbon nanotubes (MWNTs) into catalyst precursor filled iron and aluminum matrices, respectively, to directly fabricate metal-nanotube composites. Two carbon sources, carbon monoxide and acetylene were used for the synthesis of SWNTs and MWNTs, respectively. The yield strength of iron-carbon nanotube composites showed substantial enhancement of up to 45% and 36 % with 1 wt % of infiltrated SWNTs and MWNTs, respectively, relative to that of similarly treated pure iron samples of the same piece density without carbon nanotubes. Vickers hardness measurements showed an increase of 74% and 96% for iron composites filled with SWNTs and MWNTs, respectively. The use of a mixed feed of CO and acetylene resulted in carbide-free fabrication of the nanocomposites. A reaction mechanism supporting the observed carbide-free growth is also presented. In the third phase of the research performed, a SWNT fabrication protocol using CVD growth or electrophoretic deposition was employed for integrating nanotubes as biosensor and chemical gas sensor probes. For biosensor probes, vertically aligned SWNTs were grown or deposited on metal interconnects (Cr/Co), at precise locations, which were patterned on quartz substrates using photo- and e-beam Iithogrpahy to make electrical connections to each SWNT/bundle individually. Gas sensor probes were fabricated using individually suspended SWNTs contacted by Cr/Au pads as source and drain field effect transistor components for the monitoring of NO2 vapors. The adsorption of an electron donating gas such as NO2 on the SWNT sidewalls shifts the Fermi level of the p-type semiconducting nanotubes, consequently changing their electrical conductivity. Experimental results showed that sensor response to NO2 (at 10-300 ppm levels) was of the order of a few seconds at 100 ppm, and was reversible and reproducible. Recovery of the sensor response was achieved by heating the sensors at 120 °C for a period of 10-12 hours indicating physisorption of the NO2 molecules on the nanotube sidewalls

Proceedings of the 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008

This volume contains full papers presented at the 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008, held in Braga, Portugal, between September 4th and 6th, 2008.FC