69,918 research outputs found

    Hyperthermia combined with chemotherapy - Biological rationale, clinical application, and treatment results

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    There is substantial evidence from preclinical data that the antitumor cytotoxicity of selected chemotherapeutic agents either alone or combined with radiation can be enhanced by appropriate heat exposure (40-44 degrees C) of cells or tumor tissues. Based upon these results the integration of hyperthermia as an additional treatment modality, given simultaneously with systemic chemotherapy or in combination with radiochemotherapy, is currently tested at the clinic. Regional hyperthermia combined with chemotherapy or radiochemotherapy showed impressive results (phase II studies) at clinical relevant temperatures in locally advanced tumors of different entities in terms of objective response rate, local tumor control and relapse-free survival. Clinical protocols of well-designed phase III trials on combined treatment modalities integrating hyperthermia are rather limited but for some tumors confirm its clinical benefit. In general, the clinical approach to use hyperthermia has gained much more interest within in the field of medical oncology. One of the major reason is the substantial technical improvements made with the available commercial equipment for local or regional heating, especially in case of deep-seated lesions or systemic heating. Further testing of the potential of hyperthermia combined with chemotherapy or radiochemotherapy in prospective randomized trials are warranted. At this time, hyperthermia as an adjunct to conventional treatment strategies is recommended in the setting of clinical protocols. The results of prospective trials should answer the question for which types of local advanced or metastatic tumors hyperthermia becomes standard as part of a multi-modal treatment strategy

    Collaboration technology and space science

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    A summary of available collaboration technologies and their applications to space science is presented as well as investigations into remote coaching paradigms and the role of a specific collaboration tool for distributed task coordination in supporting such teleoperations. The applicability and effectiveness of different communication media and tools in supporting remote coaching are investigated. One investigation concerns a distributed check-list, a computer-based tool that allows a group of people, e.g., onboard crew, ground based investigator, and mission control, to synchronize their actions while providing full flexibility for the flight crew to set the pace and remain on their operational schedule. This autonomy is shown to contribute to morale and productivity

    mARC: Memory by Association and Reinforcement of Contexts

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    This paper introduces the memory by Association and Reinforcement of Contexts (mARC). mARC is a novel data modeling technology rooted in the second quantization formulation of quantum mechanics. It is an all-purpose incremental and unsupervised data storage and retrieval system which can be applied to all types of signal or data, structured or unstructured, textual or not. mARC can be applied to a wide range of information clas-sification and retrieval problems like e-Discovery or contextual navigation. It can also for-mulated in the artificial life framework a.k.a Conway "Game Of Life" Theory. In contrast to Conway approach, the objects evolve in a massively multidimensional space. In order to start evaluating the potential of mARC we have built a mARC-based Internet search en-gine demonstrator with contextual functionality. We compare the behavior of the mARC demonstrator with Google search both in terms of performance and relevance. In the study we find that the mARC search engine demonstrator outperforms Google search by an order of magnitude in response time while providing more relevant results for some classes of queries

    Deep Learning: Our Miraculous Year 1990-1991

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    In 2020, we will celebrate that many of the basic ideas behind the deep learning revolution were published three decades ago within fewer than 12 months in our "Annus Mirabilis" or "Miraculous Year" 1990-1991 at TU Munich. Back then, few people were interested, but a quarter century later, neural networks based on these ideas were on over 3 billion devices such as smartphones, and used many billions of times per day, consuming a significant fraction of the world's compute.Comment: 37 pages, 188 references, based on work of 4 Oct 201

    CGAMES'2009

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    Future bathroom: A study of user-centred design principles affecting usability, safety and satisfaction in bathrooms for people living with disabilities

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    Research and development work relating to assistive technology 2010-11 (Department of Health) Presented to Parliament pursuant to Section 22 of the Chronically Sick and Disabled Persons Act 197
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