Alistair Heys, The Anatomy of Bloom: Harold Bloom and the Study of Influence and Anxiety.

This 218-page book with additional pages of 437 notes and 3 pages of index (author and title) appears to have required a great deal of research or wealth of background knowledge, as it refers to an unusual number of authors and works on almost every page. If a reader starts to understand the book from the title, s/he expects an analysis, almost medical in tone (an ‘anatomy’) of the famous literary critic, perhaps with regard to his theory about literary influence; since Bloom did use the word..

Rhetorical structure and function in The Anatomy of Melancholy

In writing The Anatomy of Melancholy Robert Burton was working within the system of classical rhetoric as revived in the Renaissance, specifically the epideictic genus. A juxtaposition of the topics, arguments, and tripartite form employed by Burton with the treatment of epideictic in Aristotle's Rhetoric, as well as with aspects of the Roman and Hellenistic rhetorical traditions, shows how Burton has playfully adapted Renaissance conceptions of epideictic rhetoric forencyclopaedic, satirical, andself-expressive purposes. The function of rhetoric in the Anatomy is both to 'dissect' the corpus of knowledge about melancholy and to 'show forth' the author's own melancholic condition. © International Society for History of Rhetoric

Using neurite orientation dispersion and density imaging and tracts constrained by underlying anatomy to differentiate between subjects along the Alzheimer's disease continuum

OBJECTIVE: To assess the involvement of the white matter of the brain in the pathology of Alzheimer’s disease. Using Neurite Orientation Density and Dispersion Imaging (NODDI) and the probabilistic white matter parcellation tool Tracula as a means for understanding whether alterations in the white matter underlie changes in perceived cognitive abilities across the spectrum from health aging to Alzheimer’s disease. METHOD: Data were obtained from 28 participants in the Health Outreach Program for the Elderly (HOPE) at the Boston University Alzheimer’s Disease Center (BU ADC) Clinical Core Registry. MRI scans included an MPRAGE T1 scan, multi-b shell diffusion scan and a High Angular Resolution Diffusion Imaging scan (HARDI). Scans were processed with Freesurfer v6.0 and the NODDI Python2.7 toolkit. The resulting data included the orientation dispersion index (ODI) and Fractional Anisotropy (FA) values for cortical and subcortical regions in the DKT atlas space as well as specific Tracts Constrained by Underlying Anatomy (TRACULA) measurements for 18 specific established white matter tracts. Statistical models using measures of pathway integrity (FA and ODI data) were used to assess relationships with Informant Cognitive Change Index (ICCI), self-described Cognitive Change Index (CCI), and Clinical Dementia Rating (CDR) values. RESULTS: Measures of white matter integrity within several tracts predicted ICCI and CDR well in statistical models. FA and ODI values of the bilateral superior longitudinal fasciculi, inferior longitudinal fasciculi, and the cingulum bundle tracts were all related to ICCI and CDR. None of the known tracts’ FA or ODI values were related to CCI. CONCLUSIONS: Measures of white matter pathway integrity were predictive of ICCI and CDR scores but not CCI. These finding support the notion that self-report of cognitive abilities may be compromised by alterations in insight and reinforce the need for informed study partners and clinical ratings to evaluate potential MCI and AD

The physiologic correlates of learning in the classroom environment

This study served to further investigate learning and memory, and to offer a potential tool to support educational interventions. More specifically, this was accomplished by an investigation of the physiologic changes in the brain that occurred while students learned medical anatomy. A group of 29 students taking the Gross Anatomy course at Boston University School of Medicine participated in the study. Testing occurred in two sessions: prior to the course and at the completion of the course. For each session, scalp EEG was recorded while participants were shown 176 anatomical terms (132 relevant to the course and 44 obscure) and asked to respond with "Can Define", "Familiar", or "Don't Know". Behavioral results indicated a positive correlation between participants' course grades and performance on the experimental tasks. EEG results were analyzed for event-related potential (ERP) components related to two memory components: familiarity and recollection. Results had a number of indications. For Don't Know responses, a stronger early frontal, late parietal, and late frontal effect occurred more so for terms of Session 1 compared to Session 2. For an analysis of just Session 2 data, results indicated increased activity of the early frontal, late parietal, and late frontal effects for Can Define responses only. Session 2 Can Define responses elicited a stronger early frontal ERP, occurring between 300 and 500 milliseconds yet, the most post-retrieval processing and monitoring appeared for Can Define terms of Session 2. Ultimately, we focused on investigating two points: 1) the effect of classroom learning on memory, and 2) the examination of ERPs as a tool to guide education interventions. Specifically, ERPs would potentially indicate markers to predict whether students would retain materials long before behavioral measures indicate these results. This has potential to determine whether long-lasting or transient learning will occur; as well as the potential to support early intervention strategies for not just students, but also individuals with learning disabilities or memory impairments

The experimental foundations of Galen's teleology

This article outlines in details specific experiments that Galen performed. It explores how his methodology for experimentation was a sophisticated response to the rationalist-empirist debate as it occurred in ancient medicine

Northrop Frye in context

“Diane Dubois takes a contextual approach to Northrop Frye’s work and claims that it is best assessed in relation to his biographical circumstances. In context and in specific details, Dubois’ book seeks to illuminate Frye’s œuvre as a personal, lifelong project. This volume successfully situates Frye’s work within the social, political, religious and philosophical conditions of the time and place of conception and writing. Dubois ranges from Frye’s critical utopia and views on criticism and education through the university, church and William Blake to politics and the Canadian and academic milieu. This book, which is particularly good at tracing Frye’s academic influences and his roots in Methodism and Canada, will have a strong appeal to an international audience of general readers, students, teachers and specialists. Frye is a key figure in the cultural and literary theory of the twentieth century, and Dubois’ accomplished discussion helps us to see his work anew.” Jonathan Hart, author of Northrop Frye: The Theoretical Imagination (1994), Interpreting Cultures (2006), Empires and Colonies (2008) and Literature, Theory, History (2011

ADAM10 Localization in Temporomandibular Joint Disk with Internal Derangement: An Ex Vivo Immunohistochemical Study

The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved from the archives of the University of Catania. Of these 16 had been removed from females and 9 from males; 11 with anterior disk displacement with reduction (ADDwR) and 14 with anterior disk displacement without reduction (ADDwoR). The sections were dehydrated, embedded in paraffin and cut. Then they were incubated in 0.3% H2O2/methanol and half of sections from each sample were incubated in diluted rabbit polyclonal anti-ADAM10 antibody. Then biotinylated anti-mouse/anti-rabbit IgG was applied to the sections, followed by avidin–biotin–perioxidase complex. The results were analyzed and the results were that ADAM10 was overexpressed in the posterior band of sections from patients with ADDwR compared to the other bands of both ADDwR and ADDwoR sections. Overexpression correlated with severe histopathological degeneration. We believe these results have the potential to provide insights into the pathogenesis of TMJ disk degeneration and to help design new therapeutic approaches targeting the proteolytic events that lead to tissue degeneration. Early therapeutic block of ADAM10 activity could succeed in limiting aggrecan-rich matrix breakdown without affecting normal physiology

An investigation to examine the most appropriate methodology to capture historical and modern preserved anatomical specimens for use in the digital age to improve access: a pilot study

Anatomico-pathological specimens constitute a valuable component of many medical museums or institutional collections but can be limited in their impact on account of both physical and intellectual inaccessibility. Further concerns relate to conservation as anatomical specimens may be subject to tissue deterioration, constraints imposed by spatial or financial limitations of the host institution, or accident-based destruction. In awareness of these issues, a simple and easily implementable methodology to increase accessibility, impact and conservation of anatomical specimens is proposed which combines photogrammetry, object virtual reality (object VR), and interactive portable document format (PDF) with supplementary historical and anatomical commentary. The methodology was developed using wet, dry, and plastinated specimens from the historical and modern collections in the Museum of Anatomy at the University of Glasgow. It was found that photogrammetry yielded excellent results for plastinated specimens and showed potential for dry specimens, while object VR produced excellent photorealistic virtual specimens for all materials visualised. Use of PDF as output format was found to allow for the addition of textual, visual, and interactive content, and as such supplemented the virtual specimen with multidisciplinary information adaptable to the needs of various audiences. The results of this small-scale pilot study indicate the beneficial nature of combining these established techniques into a methodology for the digitisation and utilisation of historical anatomical collections in particular, but also collections of material culture more broadly

The relation between patient discomfort and uncompensated forces of a patient support device for breast and regional lymph node radiotherapy

Although many authors stated that a user-centred design approach in medical device development has added values, the most common research approach within healthcare is evidence-based medicine, which tend to focus on functional data rather than patient wellbeing and comfort. End user comfort is well addressed in literature for commercial products such as seats and hand tools but no data was found for medical devices. A commercial patient support device for breast radiotherapy was analysed and a relation was found between discomfort and uncompensated internal body forces. Derived from CT-images, simplified patient free-body diagrams were analysed and pain and comfort evaluated. Subsequently, a new patient position was established and prototypes were developed. Patient comfort- and prototype optimization was done through iterative prototyping. With this approach, we were able to compensate all internal body forces and establish a force neutral patient free-body diagram. This resulted in comfortable patient positioning and favourable medical results