Alzheimer Disease Detection Techniques and Methods: A Review

Brain pathological changes linked with Alzheimer's disease (AD) can be measured with Neuroimaging. In the past few years, these measures are rapidly integrated into the signatures of Alzheimer disease (AD) with the help of classification frameworks which are offering tools for diagnosis and prognosis. Here is the review study of Alzheimer's disease based on Neuroimaging and cognitive impairment classification. This work is a systematic review for the published work in the field of AD especially the computer-aided diagnosis. The imaging modalities include 1) Magnetic resonance imaging (MRI) 2) Functional MRI (fMRI) 3) Diffusion tensor imaging 4) Positron emission tomography (PET) and 5) amyloid-PET. The study revealed that the classification criterion based on the features shows promising results to diagnose the disease and helps in clinical progression. The most widely used machine learning classifiers for AD diagnosis include Support Vector Machine, Bayesian Classifiers, Linear Discriminant Analysis, and K-Nearest Neighbor along with Deep learning. The study revealed that the deep learning techniques and support vector machine give higher accuracies in the identification of Alzheimer’s disease. The possible challenges along with future directions are also discussed in the paper

Intelligent human action recognition using an ensemble model of evolving deep networks with swarm-based optimization.

Automatic interpretation of human actions from realistic videos attracts increasing research attention owing to its growing demand in real-world deployments such as biometrics, intelligent robotics, and surveillance. In this research, we propose an ensemble model of evolving deep networks comprising Convolutional Neural Networks (CNNs) and bidirectional Long Short-Term Memory (BLSTM) networks for human action recognition. A swarm intelligence (SI)-based algorithm is also proposed for identifying the optimal hyper-parameters of the deep networks. The SI algorithm plays a crucial role for determining the BLSTM network and learning configurations such as the learning and dropout rates and the number of hidden neurons, in order to establish effective deep features that accurately represent the temporal dynamics of human actions. The proposed SI algorithm incorporates hybrid crossover operators implemented by sine, cosine, and tanh functions for multiple elite offspring signal generation, as well as geometric search coefficients extracted from a three-dimensional super-ellipse surface. Moreover, it employs a versatile search process led by the yielded promising offspring solutions to overcome stagnation. Diverse CNN–BLSTM networks with distinctive hyper-parameter settings are devised. An ensemble model is subsequently constructed by aggregating a set of three optimized CNN–BLSTM​ networks based on the average prediction probabilities. Evaluated using several publicly available human action data sets, our evolving ensemble deep networks illustrate statistically significant superiority over those with default and optimal settings identified by other search methods. The proposed SI algorithm also shows great superiority over several other methods for solving diverse high-dimensional unimodal and multimodal optimization functions with artificial landscapes

Deep learning of brain asymmetry digital biomarkers to support early diagnosis of cognitive decline and dementia

Early identification of degenerative processes in the human brain is essential for proper care and treatment. This may involve different instrumental diagnostic methods, including the most popular computer tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) scans. These technologies provide detailed information about the shape, size, and function of the human brain. Structural and functional cerebral changes can be detected by computational algorithms and used to diagnose dementia and its stages (amnestic early mild cognitive impairment - EMCI, Alzheimer’s Disease - AD). They can help monitor the progress of the disease. Transformation shifts in the degree of asymmetry between the left and right hemispheres illustrate the initialization or development of a pathological process in the brain. In this vein, this study proposes a new digital biomarker for the diagnosis of early dementia based on the detection of image asymmetries and crosssectional comparison of NC (normal cognitively), EMCI and AD subjects. Features of brain asymmetries extracted from MRI of the ADNI and OASIS databases are used to analyze structural brain changes and machine learning classification of the pathology. The experimental part of the study includes results of supervised machine learning algorithms and transfer learning architectures of convolutional neural networks for distinguishing between cognitively normal subjects and patients with early or progressive dementia. The proposed pipeline offers a low-cost imaging biomarker for the classification of dementia. It can be potentially helpful to other brain degenerative disorders accompanied by changes in brain asymmetries