Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Ensembles of wrappers for automated feature selection in fish age classification

In feature selection, the most important features must be chosen so as to decrease the number thereof while retaining their discriminatory information. Within this context, a novel feature selection method based on an ensemble of wrappers is proposed and applied for automatically select features in fish age classification. The effectiveness of this procedure using an Atlantic cod database has been tested for different powerful statistical learning classifiers. The subsets based on few features selected, e.g. otolith weight and fish weight, are particularly noticeable given current biological findings and practices in fishery research and the classification results obtained with them outperforms those of previous studies in which a manual feature selection was performed.Peer ReviewedPostprint (author's final draft