Supporting UK-wide e-clinical trials and studies

As clinical trials and epidemiological studies become increasingly large, covering wider (national) geographical areas and involving ever broader populations, the need to provide an information management infrastructure that can support such endeavours is essential. A wealth of clinical data now exists at varying levels of care (primary care, secondary care, etc.). Simple, secure access to such data would greatly benefit the key processes involved in clinical trials and epidemiological studies: patient recruitment, data collection and study management. The Grid paradigm provides one model for seamless access to such data and support of these processes. The VOTES project (Virtual Organisations for Trials and Epidemiological Studies) is a collaboration between several UK institutions to implement a generic framework that effectively leverages the available health-care information across the UK to support more efficient gathering and processing of trial information. The structure of the information available in the health-care domain in the UK itself varies broadly in-line with the national boundaries of the constituent states (England, Scotland, Wales and Northern Ireland). Technologies must address these political boundaries and the impact these boundaries have in terms of for example, information governance, policies, and of course large-scale heterogeneous distribution of the data sets themselves. This paper outlines the methodology in implementing the framework between three specific data sources that serve as useful case studies: Scottish data from the Scottish Care Information (SCI) Store data repository, data on the General Practice Research Database (GPRD) diabetes trial at Imperial College London, and benign prostate hypoplasia (BPH) data from the University of Nottingham. The design, implementation and wider research issues are discussed along with the technological challenges encountered in the project in the application of Grid technologies

An Innovative Workspace for The Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is an initiative to build the next generation, ground-based gamma-ray observatories. We present a prototype workspace developed at INAF that aims at providing innovative solutions for the CTA community. The workspace leverages open source technologies providing web access to a set of tools widely used by the CTA community. Two different user interaction models, connected to an authentication and authorization infrastructure, have been implemented in this workspace. The first one is a workflow management system accessed via a science gateway (based on the Liferay platform) and the second one is an interactive virtual desktop environment. The integrated workflow system allows to run applications used in astronomy and physics researches into distributed computing infrastructures (ranging from clusters to grids and clouds). The interactive desktop environment allows to use many software packages without any installation on local desktops exploiting their native graphical user interfaces. The science gateway and the interactive desktop environment are connected to the authentication and authorization infrastructure composed by a Shibboleth identity provider and a Grouper authorization solution. The Grouper released attributes are consumed by the science gateway to authorize the access to specific web resources and the role management mechanism in Liferay provides the attribute-role mapping

The GIS Architecture Elements for the Coastal Areas Along the Adriatic Sea

The study of the national and cross-border Adriatic coastal areas will be approached by using an interdisciplinary method. A comparative reading will focus on an analysis of the main variations undergone by the area and will try to define all the elements involved in those areas where a conflicting presence exists between high quality environmental factors on the one hand and anthropological aggression on the other. In this paper we present the aim of the GES.S.TER. project, that is the creation of a protocol for territorial analysis – namely the G.I.S.A.E. Adriatic (Geographical Information System for Activities along the Coast). The Project is financed by the Interreg IIIA Programme Adriatic Cross Border from 2004 to 2007 (prof. Donatella Cialdea is the Head of GESS.S.TER.). Moreover the Project will be a case-study analysed by the GISIG - Geographical Information Systems International Group. The areas covered by the project include the national Adriatic coast, in particular the coastal area of Molise, and the cross-border coasts of Albania and Croatia (both partners in the project). In the definition of the characteristics that a territorial information system of aid to the GES.S.TER project should have, the parameters for the collection of data and for the reordering of the information, which was already in our possession, have been established. Another necessary step has been that of revising and coordinating the existing sources, keeping in mind that the final purpose of the system is to define the objective landscape qualities, we find ourselves having to face the problem of combining, and consequently, comparing, information coming from different sources. Five resource systems have been selected: physical-environmental; landscape-visual; historical-cultural; agricultural-productive; Demographic-tourism. A further source of information comes from the analysis carried out during the drawing up of the Vast Area Environmental Landscape Territorial Plans and we have defined the criteria for the selection of the indicators. These indicators will be useful for an evaluation of transformations through time of the territories, in order to prepare the documents for the strategic environmental assessment procedures too.

MusA: Using Indoor Positioning and Navigation to Enhance Cultural Experiences in a museum

In recent years there has been a growing interest into the use of multimedia mobile guides in museum environments. Mobile devices have the capabilities to detect the user context and to provide pieces of information suitable to help visitors discovering and following the logical and emotional connections that develop during the visit. In this scenario, location based services (LBS) currently represent an asset, and the choice of the technology to determine users' position, combined with the definition of methods that can effectively convey information, become key issues in the design process. In this work, we present MusA (Museum Assistant), a general framework for the development of multimedia interactive guides for mobile devices. Its main feature is a vision-based indoor positioning system that allows the provision of several LBS, from way-finding to the contextualized communication of cultural contents, aimed at providing a meaningful exploration of exhibits according to visitors' personal interest and curiosity. Starting from the thorough description of the system architecture, the article presents the implementation of two mobile guides, developed to respectively address adults and children, and discusses the evaluation of the user experience and the visitors' appreciation of these application

Census Tract License Areas: Disincentive for Sharing the 3.5GHz band?

Flexible licensing model is a necessary enabler of the technical and procedural complexities of Spectrum Access System (SAS)-based sharing framework. The purpose of this study is to explore the effectiveness of 3.5GHz Licensing Framework - based on census tracts as area units, areas whose main characteristic is population. As such, the boundary of census tract does not follow the edge of wireless network coverage. We demonstrate why census tracts are not suitable for small cell networks licensing, by (1) gathering and analysing the official census data, (2) exploring the boundaries of census tracts which are in the shape of nonconvex polygons and (3) giving a measure of effectiveness of the licensing scheme through metrics of area loss and the number of people per census tract with access to spectrum. Results show that census tracts severely impact the effectiveness of the licensing framework since almost entire strategically important cities in the U.S. will not avail from spectrum use in 3.5GHz band. Our paper does not seek to challenge the core notion of geographic licensing concept, but seeks a corrective that addresses the way the license is issued for a certain area of operation. The effects that inappropriate size of the license has on spectrum assignments lead to spectrum being simply wasted in geography, time and frequency or not being assigned in a fair manner. The corrective is necessary since the main goal of promoting innovative sharing in 3.5 GHz band is to put spectrum to more efficient use.Comment: 7 pages, 5 figures, conferenc

Supporting security-oriented, inter-disciplinary research: crossing the social, clinical and geospatial domains

How many people have had a chronic disease for longer than 5-years in Scotland? How has this impacted upon their choices of employment? Are there any geographical clusters in Scotland where a high-incidence of patients with such long-term illness can be found? How does the life expectancy of such individuals compare with the national averages? Such questions are important to understand the health of nations and the best ways in which health care should be delivered and measured for their impact and success. In tackling such research questions, e-Infrastructures need to provide tailored, secure access to an extensible range of distributed resources including primary and secondary e-Health clinical data; social science data, and geospatial data sets amongst numerous others. In this paper we describe the security models underlying these e-Infrastructures and demonstrate their implementation in supporting secure, federated access to a variety of distributed and heterogeneous data sets exploiting the results of a variety of projects at the National e-Science Centre (NeSC) at the University of Glasgow