Fully automatic segmentation of intima/adventitia of the vessel using Bezier curve from intravascular ultrasound

Although medical image segmentation field is regarded as one of most established fields, still fully automatic segmentation to extract target object with high accuracy from intravascular ultrasound (IVUS) is very active area of research. In this paper, we propose a fully automatic morphological approach using Bezier curve in interpolating the boundaries of intima/adventitia of the vessel from IVUS with careful binarization algorithms. In experiment with 800 IVUS images, the proposed method is as good as fuzzy C-means based approach in comparison with human expert’s result with 84.4% satisfaction and better than other morphological method in all performance indices of curve fitting with 97.02% in accuracy and 58.19% in precision

Thin Cap Fibroatheroma Detection in Virtual Histology Images Using Geometric and Texture Features

Atherosclerotic plaque rupture is the most common mechanism responsible for a majority of sudden coronary deaths. The precursor lesion of plaque rupture is thought to be a thin cap fibroatheroma (TCFA), or “vulnerable plaque”. Virtual Histology-Intravascular Ultrasound (VH-IVUS) images are clinically available for visualising colour-coded coronary artery tissue. However, it has limitations in terms of providing clinically relevant information for identifying vulnerable plaque. The aim of this research is to improve the identification of TCFA using VH-IVUS images. To more accurately segment VH-IVUS images, a semi-supervised model is developed by means of hybrid K-means with Particle Swarm Optimisation (PSO) and a minimum Euclidean distance algorithm (KMPSO-mED). Another novelty of the proposed method is fusion of different geometric and informative texture features to capture the varying heterogeneity of plaque components and compute a discriminative index for TCFA plaque, while the existing research on TCFA detection has only focused on the geometric features. Three commonly used statistical texture features are extracted from VH-IVUS images: Local Binary Patterns (LBP), Grey Level Co-occurrence Matrix (GLCM), and Modified Run Length (MRL). Geometric and texture features are concatenated in order to generate complex descriptors. Finally, Back Propagation Neural Network (BPNN), kNN (K-Nearest Neighbour), and Support Vector Machine (SVM) classifiers are applied to select the best classifier for classifying plaque into TCFA and Non-TCFA. The present study proposes a fast and accurate computer-aided method for plaque type classification. The proposed method is applied to 588 VH-IVUS images obtained from 10 patients. The results prove the superiority of the proposed method, with accuracy rates of 98.61% for TCFA plaque.This research was funded by Universiti Teknologi Malaysia (UTM) under Research University Grant Vot-02G31, and the Ministry of Higher Education Malaysia (MOHE) under the Fundamental Research Grant Scheme (FRGS Vot-4F551) for the completion of the research. The work and the contribution were also supported by the project Smart Solutions in Ubiquitous Computing Environments, Grant Agency of Excellence, University of Hradec Kralove, Faculty of Informatics and Management, Czech Republic (under ID: UHK-FIM-GE-2018). Furthermore, the research is also partially supported by the Spanish Ministry of Science, Innovation and Universities with FEDER funds in the project TIN2016-75850-R

Advanced deep learning methodology for accurate, real-time segmentation of high-resolution intravascular ultrasound images

AIMS: The aim of this study is to develop and validate a deep learning (DL) methodology capable of automated and accurate segmentation of intravascular ultrasound (IVUS) image sequences in real-time. METHODS AND RESULTS: IVUS segmentation was performed by two experts who manually annotated the external elastic membrane (EEM) and lumen borders in the end-diastolic frames of 197 IVUS sequences portraying the native coronary arteries of 65 patients. The IVUS sequences of 177 randomly-selected vessels were used to train and optimise a novel DL model for the segmentation of IVUS images. Validation of the developed methodology was performed in 20 vessels using the estimations of two expert analysts as the reference standard. The mean difference for the EEM, lumen and plaque area between the DL-methodology and the analysts was ≤0.23mm2 (standard deviation ≤0.85mm2), while the Hausdorff and mean distance differences for the EEM and lumen borders was ≤0.19 mm (standard deviation≤0.17 mm). The agreement between DL and experts was similar to experts' agreement (Williams Index ranges: 0.754-1.061) with similar results in frames portraying calcific plaques or side branches. CONCLUSIONS: The developed DL-methodology appears accurate and capable of segmenting high-resolution real-world IVUS datasets. These features are expected to facilitate its broad adoption and enhance the applications of IVUS in clinical practice and research

Combinatorial optimisation for arterial image segmentation.

Cardiovascular disease is one of the leading causes of the mortality in the western world. Many imaging modalities have been used to diagnose cardiovascular diseases. However, each has different forms of noise and artifacts that make the medical image analysis field important and challenging. This thesis is concerned with developing fully automatic segmentation methods for cross-sectional coronary arterial imaging in particular, intra-vascular ultrasound and optical coherence tomography, by incorporating prior and tracking information without any user intervention, to effectively overcome various image artifacts and occlusions. Combinatorial optimisation methods are proposed to solve the segmentation problem in polynomial time. A node-weighted directed graph is constructed so that the vessel border delineation is considered as computing a minimum closed set. A set of complementary edge and texture features is extracted. Single and double interface segmentation methods are introduced. Novel optimisation of the boundary energy function is proposed based on a supervised classification method. Shape prior model is incorporated into the segmentation framework based on global and local information through the energy function design and graph construction. A combination of cross-sectional segmentation and longitudinal tracking is proposed using the Kalman filter and the hidden Markov model. The border is parameterised using the radial basis functions. The Kalman filter is used to adapt the inter-frame constraints between every two consecutive frames to obtain coherent temporal segmentation. An HMM-based border tracking method is also proposed in which the emission probability is derived from both the classification-based cost function and the shape prior model. The optimal sequence of the hidden states is computed using the Viterbi algorithm. Both qualitative and quantitative results on thousands of images show superior performance of the proposed methods compared to a number of state-of-the-art segmentation methods

Automatic segmentation of cross-sectional coronary arterial images

We present a novel approach to segment coronary cross-sectional images acquired using catheterization imaging techniques, i.e. intra-vascular ultrasound (IVUS) and optical coherence tomography (OCT). The proposed approach combines cross-sectional segmentation with longitudinal tracking in order to tackle various forms of imaging artifacts and to achieve consistent segmentation. A node-weighted directed graph is constructed on two consecutive cross-sectional frames with embedded shape constraints within individual cross-sections or frames and between consecutive frames. The intra-frame constraints are derived from a set of training samples and are embedded in both graph construction and its cost function. The inter-frame constraints are imposed by tracking the borders of interest across multiple frames. The coronary images are transformed from Cartesian coordinates to polar coordinates. Graph partition can then be formulated as searching an optimal interface in the node-weighted directed graph without user initialization. It also allows efficient parametrization of the border using radial basis function (RBF) and thus reduces the tracking of a large number of border points to a very few RBF centers. Moreover, we carry out supervised column-wise tissue classification in order to automatically optimize the feature selection. Instead of empirically assigning weights to different feature detectors, we dynamically and automatically adapt those weighting depending on the tissue compositions in each individual column of pixels