308 research outputs found

    An activity canyon characterization of the pharmacological topography

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    Reconsolidation: Unique Cognitive Process or State Dependent Learning?

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    Accessing a previously consolidated memory trace brings it back into a labile state where it must then undergo a re-stabilization process known as reconsolidation. During this process memories are susceptible to interference and may be updated with new information. Reconsolidation has been demonstrated in animals as well as in the procedural and episodic human memory systems. However, it is still unclear when the effect will occur. Some studies suggest that reconsolidation is only necessary when new information is presented in the same spatial context or when prediction error occurs. More recent work has provided evidence that reconsolidation could be due to state dependent learning. Here, we aim to determine if an existing cognitive phenomenon, such as state dependent learning, can explain various reconsolidation effects. Experiment 1 examined that possibility using mood as internal states and then matching or mismatching moods during select study days and test. Experiment 2 further expanded on this possibility by matching (or mismatching) states on all days throughout the experiment

    Dragon-kings: mechanisms, statistical methods and empirical evidence

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    This introductory article presents the special Discussion and Debate volume "From black swans to dragon-kings, is there life beyond power laws?" published in Eur. Phys. J. Special Topics in May 2012. We summarize and put in perspective the contributions into three main themes: (i) mechanisms for dragon-kings, (ii) detection of dragon-kings and statistical tests and (iii) empirical evidence in a large variety of natural and social systems. Overall, we are pleased to witness significant advances both in the introduction and clarification of underlying mechanisms and in the development of novel efficient tests that demonstrate clear evidence for the presence of dragon-kings in many systems. However, this positive view should be balanced by the fact that this remains a very delicate and difficult field, if only due to the scarcity of data as well as the extraordinary important implications with respect to hazard assessment, risk control and predictability.Comment: 20 page

    The Second Conference on Lunar Bases and Space Activities of the 21st Century, volume 1

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    These papers comprise a peer-review selection of presentations by authors from NASA, LPI industry, and academia at the Second Conference (April 1988) on Lunar Bases and Space Activities of the 21st Century, sponsored by the NASA Office of Exploration and the Lunar Planetary Institute. These papers go into more technical depth than did those published from the first NASA-sponsored symposium on the topic, held in 1984. Session topics covered by this volume include (1) design and operation of transportation systems to, in orbit around, and on the Moon, (2) lunar base site selection, (3) design, architecture, construction, and operation of lunar bases and human habitats, and (4) lunar-based scientific research and experimentation in astronomy, exobiology, and lunar geology

    STRUCTURAL STUDIES ON CELL ENTRY OF RESPIRATORY ENTEROVIRUSES

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    Enteroviruses (EVs) represent a group of non-enveloped, positive strand RN

    PROGRAM and PROCEEDINGS THE NEBRASKA ACADEMY OF SCIENCES 1880-2017 Including the Nebraska Association of Teachers of Science (NATS) Division Nebraska Junior Academy of Sciences (NJAS) Affiliate and Affiliated Societies

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    FRIDAY, APRIL 21, 2017 7:30 a.m. REGISTRATION FOR ACADEMY, Lobby of Lecture wing, Olin Hall 8:00 Aeronautics and Space Science, Session A, Olin 249 Aeronautics and Space Science, Session B, Olin 224 Chemistry and Physics, Section A, Chemistry, Olin A Collegiate Academy, Biology, Session A, Olin B Collegiate Academy, Biology, Session B, Olin 112 Collegiate Academy, Chemistry and Physics, Session A, Olin 324 8:30 Biological and Medical Sciences, Session A, Smith Callen Conference Center 9:10 Aeronautics and Space Science, Poster Session, Olin 249 9:40 Applied Science and Technology, Olin 325 10:00 Chemistry and Physics, Physics, Section B, Planetarium 10:30 Aeronautics and Space Science, Poster Session, Olin 249 11:00 MAIBEN MEMORIAL LECTURE, OLIN B – Scholarship and Friend of Science Recipients also announced. 12:00 LUNCH, PATIO ROOM, STORY STUDENT CENTER Aeronautics Group, Sunflower Room 1:00 p.m. Anthropology, Olin 111 Biological and Medical Sciences, Session B, Smith Callen Conference Center Collegiate Academy, Biology, Session A, Olin B Collegiate Academy, Biology, Session B, Olin 112 Collegiate Academy, Chemistry and Physics, Session B, Olin 324 Earth Science, Olin 249 1:05 Applied Science and Technology, Olin 325 1:15 Teaching of Science and Math, Olin 224 Chemistry and Physics, Section A, Chemistry, Olin A 2:45 Environmental Sciences, Olin 249 4:30 BUSINESS MEETING, OLIN B Abstracts of papers 2016-2017 EXECUTIVE COMMITTEE 2016-2017 PROGRAM COMMITTEE 2016-2017 POLICY COMMITTEE FRIENDS OF THE ACADEMY FRIEND OF SCIENCE AWARD WINNERS FRIEND OF SCIENCE AWARD TO KACIE BAUM FRIEND OF SCIENCE AWARD TO TODD YOUNG Author Index 141 p

    Faculty Publications and Creative Works 2003

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    Faculty Publications & Creative Works is an annual compendium of scholarly and creative activities of University of New Mexico faculty during the noted calendar year. It serves to illustrate the robust and active intellectual pursuits conducted by the faculty in support of teaching and research at UNM

    Organised neural networks in culture

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    The aim of my research was to recreate simple, spatially organised neural networks in culture for the study of neural network behaviour. Spinal cord neurons were chosen as the biological model, as much is already known about spinal cord tissue circuitry in-vivo. These simple networks of cells were created by chemical patterning techniques (micro-contact printing (mCP)), and topographical guidance mechanisms. mCP was used to test the hypothesis that alterations in network architecture could affect network behaviour. Changes in network structures were identified, using immunocytochemical staining and scanning electron microscopy (SEM). Of the six patterns tested it was concluded that the Jude pattern did not satisfy the criteria required for a neural network. Cells failed to comply to the extreme angles of this design and so a hexagonal pattern was introduced. Dendritic architecture, of varying designs, was incorporated into these hexagonal networks with the aim of determining if variation in dendritic arborisation could affect network activity. An analysis of the result showed that cell morphology and connectivity was visibly altered, suggesting network characteristics were affected. An attempt was made to create organised nerve cultures using micro-metric grooved patterns in poly-dimethylsiloxane (PDMS). The cellular response was determined by immunocytochemical staining and SEM imaging. Cells grown on micrometric topographical patterns did not align within the grooves as predicted. Therefore the effect of nano-metric pillared topography, created in poly-caprolactone, on nerve cell guidance was investigated. In comparison to the flat material, this nanotopography reduced cell adhesion, although it was not completely non-adhesive. After 1 week cells were visibly aligning to the topography, at the micro-and nanometric level, and appeared to be growing longer processes compared to the cells grown on flat structures. This result suggests nanopillared topography has a promising future in nerve guidance studies
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