Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components

This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public database of 75 4-channel non-invasive maternal abdominal recordings was used for training the algorithm. Four methods were developed and assessed to determine the optimal PC: (1) power spectral distribution, (2) root mean square, (3) sample entropy, and (4) QRS template. The sensitivity of the performance of the algorithm to large-amplitude noise removal (by wavelet de-noising) and maternal beat cancellation methods were also assessed. The accuracy of maternal and fetal beat detection was assessed against reference annotations and quantified using the detection accuracy score F1 [2*PPV*Se / (PPV + Se)], sensitivity (Se), and positive predictive value (PPV). The best performing implementation was assessed on a test dataset of 100 recordings and the agreement between the computed and the reference fetal heart rate (fHR) and fetal RR (fRR) time series quantified. The best performance for detecting maternal beats (F1 99.3%, Se 99.0%, PPV 99.7%) was obtained when using the QRS template method to select the optimal maternal PC and applying wavelet de-noising. The best performance for detecting fetal beats (F1 89.8%, Se 89.3%, PPV 90.5%) was obtained when the optimal fetal PC was selected using the sample entropy method and utilising a fixed-length time window for the cancellation of the maternal beats. The performance on the test dataset was 142.7 beats2/min2 for fHR and 19.9 ms for fRR, ranking respectively 14 and 17 (out of 29) when compared to the other algorithms presented at the Physionet Challenge 2013

Novel hybrid extraction systems for fetal heart rate variability monitoring based on non-invasive fetal electrocardiogram

This study focuses on the design, implementation and subsequent verification of a new type of hybrid extraction system for noninvasive fetal electrocardiogram (NI-fECG) processing. The system designed combines the advantages of individual adaptive and non-adaptive algorithms. The pilot study reviews two innovative hybrid systems called ICA-ANFIS-WT and ICA-RLS-WT. This is a combination of independent component analysis (ICA), adaptive neuro-fuzzy inference system (ANFIS) algorithm or recursive least squares (RLS) algorithm and wavelet transform (WT) algorithm. The study was conducted on clinical practice data (extended ADFECGDB database and Physionet Challenge 2013 database) from the perspective of non-invasive fetal heart rate variability monitoring based on the determination of the overall probability of correct detection (ACC), sensitivity (SE), positive predictive value (PPV) and harmonic mean between SE and PPV (F1). System functionality was verified against a relevant reference obtained by an invasive way using a scalp electrode (ADFECGDB database), or relevant reference obtained by annotations (Physionet Challenge 2013 database). The study showed that ICA-RLS-WT hybrid system achieve better results than ICA-ANFIS-WT. During experiment on ADFECGDB database, the ICA-RLS-WT hybrid system reached ACC > 80 % on 9 recordings out of 12 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 6 recordings out of 12. During experiment on Physionet Challenge 2013 database the ICA-RLS-WT hybrid system reached ACC > 80 % on 13 recordings out of 25 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 7 recordings out of 25. Both hybrid systems achieve provably better results than the individual algorithms tested in previous studies.Web of Science713178413175

Hybrid methods based on empirical mode decomposition for non-invasive fetal heart rate monitoring

This study focuses on fetal electrocardiogram (fECG) processing using hybrid methods that combine two or more individual methods. Combinations of independent component analysis (ICA), wavelet transform (WT), recursive least squares (RLS), and empirical mode decomposition (EMD) were used to create the individual hybrid methods. Following four hybrid methods were compared and evaluated in this study: ICA-EMD, ICA-EMD-WT, EMD-WT, and ICA-RLS-EMD. The methods were tested on two databases, the ADFECGDB database and the PhysioNet Challenge 2013 database. Extraction evaluation is based on fetal heart rate (fHR) determination. Statistical evaluation is based on determination of correct detection (ACC), sensitivity (Se), positive predictive value (PPV), and harmonic mean between Se and PPV (F1). In this study, the best results were achieved by means of the ICA-RLS-EMD hybrid method, which achieved accuracy(ACC) > 80% at 9 out of 12 recordings when tested on the ADFECGDB database, reaching an average value of ACC > 84%, Se > 87%, PPV > 92%, and F1 > 90%. When tested on the Physionet Challenge 2013 database, ACC > 80% was achieved at 12 out of 25 recordings with an average value of ACC > 64%, Se > 69%, PPV > 79%, and F1 > 72%.Web of Science8512185120

Detection of atrial fibrillation episodes in long-term heart rhythm signals using a support vector machine

Atrial fibrillation (AF) is a serious heart arrhythmia leading to a significant increase of the risk for occurrence of ischemic stroke. Clinically, the AF episode is recognized in an electrocardiogram. However, detection of asymptomatic AF, which requires a long-term monitoring, is more efficient when based on irregularity of beat-to-beat intervals estimated by the heart rate (HR) features. Automated classification of heartbeats into AF and non-AF by means of the Lagrangian Support Vector Machine has been proposed. The classifier input vector consisted of sixteen features, including four coefficients very sensitive to beat-to-beat heart changes, taken from the fetal heart rate analysis in perinatal medicine. Effectiveness of the proposed classifier has been verified on the MIT-BIH Atrial Fibrillation Database. Designing of the LSVM classifier using very large number of feature vectors requires extreme computational efforts. Therefore, an original approach has been proposed to determine a training set of the smallest possible size that still would guarantee a high quality of AF detection. It enables to obtain satisfactory results using only 1.39% of all heartbeats as the training data. Post-processing stage based on aggregation of classified heartbeats into AF episodes has been applied to provide more reliable information on patient risk. Results obtained during the testing phase showed the sensitivity of 98.94%, positive predictive value of 98.39%, and classification accuracy of 98.86%.Web of Science203art. no. 76

Methods of power line interference elimination in EMG signals

Electromyogram (EMG) recordings are often corrupted by the wide range of artifacts, which one of them is power line interference (PLI). The study focuses on some of the well-known signal processing approaches used to eliminate or attenuate PLI from EMG signal. The results are compared using signal-to-noise ratio (SNR), correlation coefficients and Bland-Altman analysis for each tested method: notch filter, adaptive noise canceller (ANC) and wavelet transform (WT). Thus, the power of the remaining noise and shape of the output signal are analysed. The results show that the ANC method gives the best output SNR and lowest shape distortion compared to the other methods.Web of Science40706

Nonlinear Adaptive Signal Processing Improves the Diagnostic Quality of Transabdominal Fetal Electrocardiography

The abdominal fetal electrocardiogram (fECG) conveys valuable information that can aid clinicians with the diagnosis and monitoring of a potentially at risk fetus during pregnancy and in childbirth. This chapter primarily focuses on noninvasive (external and indirect) transabdominal fECG monitoring. Even though it is the preferred monitoring method, unlike its classical invasive (internal and direct) counterpart (transvaginal monitoring), it may be contaminated by a variety of undesirable signals that deteriorate its quality and reduce its value in reliable detection of hypoxic conditions in the fetus. A stronger maternal electrocardiogram (the mECG signal) along with technical and biological artifacts constitutes the main interfering signal components that diminish the diagnostic quality of the transabdominal fECG recordings. Currently, transabdominal fECG monitoring relies solely on the determination of the fetus’ pulse or heart rate (FHR) by detecting RR intervals and does not take into account the morphology and duration of the fECG waves (P, QRS, T), intervals, and segments, which collectively convey very useful diagnostic information in adult cardiology. The main reason for the exclusion of these valuable pieces of information in the determination of the fetus’ status from clinical practice is the fact that there are no sufficiently reliable and well-proven techniques for accurate extraction of fECG signals and robust derivation of these informative features. To address this shortcoming in fetal cardiology, we focus on adaptive signal processing methods and pay particular attention to nonlinear approaches that carry great promise in improving the quality of transabdominal fECG monitoring and consequently impacting fetal cardiology in clinical practice. Our investigation and experimental results by using clinical-quality synthetic data generated by our novel fECG signal generator suggest that adaptive neuro-fuzzy inference systems could produce a significant advancement in fetal monitoring during pregnancy and childbirth. The possibility of using a single device to leverage two advanced methods of fetal monitoring, namely noninvasive cardiotocography (CTG) and ST segment analysis (STAN) simultaneously, to detect fetal hypoxic conditions is very promising

A phonocardiographic-based fiber-optic sensor and adaptive filtering system for noninvasive continuous fetal heart rate monitoring

This paper focuses on the design, realization, and verification of a novel phonocardiographic-based fiber-optic sensor and adaptive signal processing system for noninvasive continuous fetal heart rate (fHR) monitoring. Our proposed system utilizes two Mach-Zehnder interferometeric sensors. Based on the analysis of real measurement data, we developed a simplified dynamic model for the generation and distribution of heart sounds throughout the human body. Building on this signal model, we then designed, implemented, and verified our adaptive signal processing system by implementing two stochastic gradient-based algorithms: the Least Mean Square Algorithm (LMS), and the Normalized Least Mean Square (NLMS) Algorithm. With this system we were able to extract the fHR information from high quality fetal phonocardiograms (fPCGs), filtered from abdominal maternal phonocardiograms (mPCGs) by performing fPCG signal peak detection. Common signal processing methods such as linear filtering, signal subtraction, and others could not be used for this purpose as fPCG and mPCG signals share overlapping frequency spectra. The performance of the adaptive system was evaluated by using both qualitative (gynecological studies) and quantitative measures such as: Signal-to-Noise Ratio-SNR, Root Mean Square Error-RMSE, Sensitivity-S+, and Positive Predictive Value-PPV.Web of Science174art. no. 89