Apples to apples? Neural correlates of emotion regulation differences between high- and low-risk adolescents

Adolescence has been noted as a period of increased risk taking. The literature on normative neurodevelopment implicates aberrant activation of affective and regulatory regions as key to inhibitory failures. However, many of these studies have not included adolescents engaging in high rates of risky behavior, making generalizations to the most at-risk populations potentially problematic. We conducted a comparative study of nondelinquent community (n = 24, mean age = 15.8 years, 12 female) and delinquent adolescents (n = 24, mean age = 16.2 years, 12 female) who completed a cognitive control task during functional magnetic resonance imaging, where behavioral inhibition was assessed in the presence of appetitive and aversive socioaffective cues. Community adolescents showed poorer behavioral regulation to appetitive relative to aversive cues, whereas the delinquent sample showed the opposite pattern. Recruitment of the inferior frontal gyrus, medial prefrontal cortex, and tempoparietal junction differentiated community and high-risk adolescents, as delinquent adolescents showed significantly greater recruitment when inhibiting their responses in the presence of aversive cues, while the community sample showed greater recruitment when inhibiting their responses in the presence of appetitive cues. Accounting for behavioral history may be key in understanding when adolescents will have regulatory difficulties, highlighting a need for comparative research into normative and nonnormative risk-taking trajectories

Adaptive Adolescent Flexibility: Neurodevelopment of Decision-making and Learning in a Risky Context

Research on adolescence has largely focused on the particular biological and neural changes that place teens at risk for negative outcomes linked to increases in sensation-seeking and risky behavior. However, there is a growing interest in the adaptive function of adolescence, with work highlighting the dual nature of adolescence as a period of potential risk and opportunity. We examined how behavioral and neural sensitivity to risk and reward varies as a function of age using the Balloon Analog Risk Task. Seventy-seven children and adolescents (ages 8–17 years) completed the Balloon Analog Risk Task during an fMRI session. Results indicate that adolescents show greater learning throughout the task. Furthermore, older participants showed increased neural responses to reward in the OFC and ventral striatum, increased activation to risk in the mid-cingulate cortex, as well as increased functional OFC–medial PFC coupling in both risk and reward contexts. Age-related changes in regional activity and interregional connectivity explain the link between age and increases in flexible learning. These results support the idea that adolescents’ sensitivity to risk and reward supports adaptive learning and behavioral approaches for reward acquisition

Risk-Taking Behaviors As Predicted By (Mal)Adaptive Functioning In College Students: A Look Into Emotional Adjustment

Risk-taking behaviors emerge, increase, and peak during adolescence and have shown to continue into late adolescence. Research has begun to explore how some forms of risk-taking may be normative and adaptive. The aim of this study is to look at how social, academic, and occupational functioning are related to risk-behaviors, as measured by risk-favorability and reported risk-taking history, and emotional adjustment in a college sample (N=314). Risk was assessed using self-report and an implicit task, both of which were moderately correlated. Both risk measures were negatively correlated with self-report measures of adaptive functioning and emotional adjustment.A series of mediation analyses were performed to evaluate whether risk-taking behaviors may mediate the relationship between emotional adjustment and adaptive functioning. Risk-taking and emotional adjustment measures were both negatively correlated with adaptive functioning outcomes; however, in each of the mediation analyses the association between risk-favorability and adaptive functioning was not statistically significant when accounting for emotional adjustment. These findings suggest that emotional adjustment may be a stronger predictor of poor adaptive functioning outcomes than risk-taking

Mother still knows best: Maternal influence uniquely modulates adolescent reward sensitivity during risk taking

Adolescent decision-making is highly sensitive to input from the social environment. In particular, adult and maternal presence influence adolescents to make safer decisions when encountered with risky scenarios. However, it is currently unknown whether maternal presence confers a greater advantage than mere adult presence in buffering adolescent risk taking. In the current study, 23 adolescents completed a risk-taking task during an fMRI scan in the presence of their mother and an unknown adult. Results reveal that maternal presence elicits greater activation in reward-related neural circuits when making safe decisions but decreased activation following risky choices. Moreover, adolescents evidenced a more immature neural phenotype when making risky choices in the presence of an adult compared to mother, as evidenced by positive functional coupling between the ventral striatum and medial prefrontal cortex. Our results underscore the importance of maternal stimuli in bolstering adolescent decision-making in risky scenarios

Failure to retreat: Blunted sensitivity to negative feedback supports risky behavior in adolescents

Decision-making processes rarely occur in isolation. Rather, representations are updated constantly based on feedback to past decisions and actions. However, previous research has focused on the reaction to feedback receipt itself, instead of examining how feedback information is integrated into future decisions. In the current study, we examined differential neural sensitivity during risk decisions following positive versus negative feedback in a risk-taking context, and how this differential sensitivity is linked to adolescent risk behavior. Fifty-eight adolescents (ages 13–17 years) completed the Balloon Analogue Risk Task (BART) during an fMRI session and reported on their levels of risk-taking behavior. Results show that reduced medial PFC (mPFC) response following negative versus positive feedback is associated with fewer reductions in task-based risky decisions following negative feedback, as well as increased self-reported risk-taking behavior. These results suggest that reduced neural integration of negative feedback into during future decisions supports risky behavior, perhaps by discounting negative relative to positive feedback information when making subsequent risky decisions

Retaining Adolescent and Young Adult Participants in Research During a Pandemic: Best Practices From Two Large-Scale Developmental Neuroimaging Studies (NCANDA and ABCD)

The novel coronavirus pandemic that emerged in late 2019 (COVID-19) has created challenges not previously experienced in human research. This paper discusses two large-scale NIH-funded multi-site longitudinal studies of adolescents and young adults – the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD) Study – and valuable approaches to learn about adaptive processes for conducting developmentally sensitive research with neuroimaging and neurocognitive testing across consortia during a global pandemic. We focus on challenges experienced during the pandemic and modifications that may guide other projects, such as implementing adapted protocols that protect the safety of participants and research staff, and addressing assessment challenges through the use of strategies such as remote and mobile assessments. Given the pandemic’s disproportionate impacts on participants typically underrepresented in research, we describe efforts to retain these individuals. The pandemic provides an opportunity to develop adaptive processes that can facilitate future studies’ ability to mobilize effectively and rapidly

Adverse Childhood Experiences, Neuroadaptation, and Resilience: Does Trauma Focused Cognitive Behavioral Therapy Go Far Enough?

Adverse childhood experiences (ACEs) pose a significant public health risk. Current literature suggests ACEs have the potential to significantly disrupt sensitive periods of neurodevelopment. These neuroadaptations can result in social, emotional, and cognitive impairments that place a child at a significantly greater risk for adopting health risk behaviors and lifestyle factors that lead to the major causes of disease, disability, social problems, and early death in adults. Mental health clinicians have a unique opportunity to intervene by working with families to alter the trajectories of the child’s health risk behaviors and lifestyle factors. Trauma Focused Cognitive Behavioral Therapy (TF-CBT), a common trauma treatment modality for children will be reviewed for its efficacy and limitations in promoting long-term pro-health outcomes. Finally, implications for clinical practice will be identified including recommendations that emphasize the development and maintenance of skills and strategies that increase resilience. Recommendations will be provided in the context of promoting long-term pro-health outcomes through the implementation of TF-CBT, in order to aid mental health clinicians in meeting the unique needs of children and families recovering from adversity

Social re-orientation and brain development: An expanded and updated view.

Social development has been the focus of a great deal of neuroscience based research over the past decade. In this review, we focus on providing a framework for understanding how changes in facets of social development may correspond with changes in brain function. We argue that (1) distinct phases of social behavior emerge based on whether the organizing social force is the mother, peer play, peer integration, or romantic intimacy; (2) each phase is marked by a high degree of affect-driven motivation that elicits a distinct response in subcortical structures; (3) activity generated by these structures interacts with circuits in prefrontal cortex that guide executive functions, and occipital and temporal lobe circuits, which generate specific sensory and perceptual social representations. We propose that the direction, magnitude and duration of interaction among these affective, executive, and perceptual systems may relate to distinct sensitive periods across development that contribute to establishing long-term patterns of brain function and behavior