8 research outputs found
Multimodel Approaches for Plasma Glucose Estimation in Continuous Glucose Monitoring. Development of New Calibration Algorithms
ABSTRACT
Diabetes Mellitus (DM) embraces a group of metabolic diseases which main characteristic is the presence of high glucose levels in blood. It is one of the diseases with major social and health impact, both for its prevalence and also the consequences of the chronic complications that it implies.
One of the research lines to improve the quality of life of people with diabetes is of technical focus. It involves several lines of research, including the development and improvement of devices to estimate "online" plasma glucose: continuous glucose monitoring systems (CGMS), both invasive and non-invasive. These devices estimate plasma glucose from sensor measurements from compartments alternative to blood. Current commercially available CGMS are minimally invasive and offer an estimation of plasma glucose from measurements in the interstitial fluid
CGMS is a key component of the technical approach to build the artificial pancreas, aiming at closing the loop in combination with an insulin pump. Yet, the accuracy of current CGMS is still poor and it may partly depend on low performance of the implemented Calibration Algorithm (CA). In addition, the sensor-to-patient sensitivity is different between patients and also for the same patient in time.
It is clear, then, that the development of new efficient calibration algorithms for CGMS is an interesting and challenging problem.
The indirect measurement of plasma glucose through interstitial glucose is a main confounder of CGMS accuracy. Many components take part in the glucose transport dynamics. Indeed, physiology might suggest the existence of different local behaviors in the glucose transport process.
For this reason, local modeling techniques may be the best option for the structure of the desired CA. Thus, similar input samples are represented by the same local model. The integration of all of them considering the input regions where they are valid is the final model of the whole data set.
Clustering is tBarceló Rico, F. (2012). Multimodel Approaches for Plasma Glucose Estimation in Continuous Glucose Monitoring. Development of New Calibration Algorithms [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/17173Palanci
Uncertainty in time-to-event distributions' parameters estimates in discrete event simulation models
Viral infections in 47 CVID patients in allergy and immunology department of Rasool E Akram hospital in Tehran
Background: CVID is a heterogeneous primary immune deficiency with infectious,
autoimmune and autoinflamatory features. It is most common symptomatic PID in Iran, with
prevalence of 1 in 25000 to 50000 people. CVID has been divided into some phenotypes to
produce more homogenized subpopulations. CVID is not a pure Ab deficiency .and because of
both abnormalities in Tcell and innate immunity in combination with B cell dysfunction these
patients are predisposed to viral and opportunistic infections.
Method: prevalence of viral infections is reported in 47 CVID patients registered in Rasool
E Akram hospital in Tehran. Patients have been diagnosed as CVID with the PAGID-ESID
diagnostic criteria in our department or referred from other clinics for follow up and treatment.
Diagnosis of viral germs has been made by clinical signs, pathological significances and in
some cases by PCR.
Cases: 9 patients (19%) had problems with viral infections. Infections occurred befor diagnosis
of CVID in some cases or after that. Four patients (8.5 %) had problems with wart. Sever
mucocutaneus HSV infection has occurred in 3 (6 %), recurrent zona in one (2 %) and CMV
infection as colitis or pneumonitis in 3(6 %) patients. Sever progressive lethal CNS infection
with JC virus occurred in one patient.
Conclusion: evidences show that CVID is not a pure B cell defect, and we should be aware of
opportunistic and viral infections that in some cases may be fatal