4,940 research outputs found
PHT-bot: Deep-Learning based system for automatic risk stratification of COPD patients based upon signs of Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity
and mortality worldwide. Identifying those at highest risk of deterioration
would allow more effective distribution of preventative and surveillance
resources. Secondary pulmonary hypertension is a manifestation of advanced
COPD, which can be reliably diagnosed by the main Pulmonary Artery (PA) to
Ascending Aorta (Ao) ratio. In effect, a PA diameter to Ao diameter ratio of
greater than 1 has been demonstrated to be a reliable marker of increased
pulmonary arterial pressure. Although clinically valuable and readily
visualized, the manual assessment of the PA and the Ao diameters is time
consuming and under-reported. The present study describes a non invasive method
to measure the diameters of both the Ao and the PA from contrast-enhanced chest
Computed Tomography (CT). The solution applies deep learning techniques in
order to select the correct axial slice to measure, and to segment both
arteries. The system achieves test Pearson correlation coefficient scores of
93% for the Ao and 92% for the PA. To the best of our knowledge, it is the
first such fully automated solution
3D MODELLING AND RAPID PROTOTYPING FOR CARDIOVASCULAR SURGICAL PLANNING – TWO CASE STUDIES
In the last years, cardiovascular diagnosis, surgical planning and intervention have taken advantages from 3D modelling and rapid
prototyping techniques. The starting data for the whole process is represented by medical imagery, in particular, but not exclusively,
computed tomography (CT) or multi-slice CT (MCT) and magnetic resonance imaging (MRI). On the medical imagery, regions of
interest, i.e. heart chambers, valves, aorta, coronary vessels, etc., are segmented and converted into 3D models, which can be finally
converted in physical replicas through 3D printing procedure. In this work, an overview on modern approaches for automatic and semiautomatic
segmentation of medical imagery for 3D surface model generation is provided. The issue of accuracy check of surface
models is also addressed, together with the critical aspects of converting digital models into physical replicas through 3D printing
techniques. A patient-specific 3D modelling and printing procedure (Figure 1), for surgical planning in case of complex heart diseases
was developed. The procedure was applied to two case studies, for which MCT scans of the chest are available. In the article, a detailed
description on the implemented patient-specific modelling procedure is provided, along with a general discussion on the potentiality
and future developments of personalized 3D modelling and printing for surgical planning and surgeons practice
Image quality and dosimetry of a dual source computed tomography scanner with special emphasis on radiation dose of lung in a chest examination
The purpose of the current study was to evaluate the Dual Source Computed Tomography scanner in terms of Image quality and dosimetry with special emphasis of radiation dose of lung in a Chest examination.Zielsetzung der Studie war die Evaluation eines Dual-Source-Computertomographen hinsichtlich Bildqualität und Dosimetrie mit speziellem Fokus auf der Lungendosis in Thoraxuntersuchungen
Optimization of CT scanning protocol of Type B aortic dissection follow-up through 3D printed model
This research aims to develop and evaluate a human tissue-like material 3D printed model used as a phantom in determining optimized scanning parameters to reduce the radiation dose for Type B aortic dissection patients after thoracic endovascular aortic repair. The results show that radiation risk for follow-up Type B aortic dissection patients can be potentially reduced. Further, the value of using 3D printed model in studying CT scanning protocols was further validated
Serial decline in lung volume parameters on computed tomography (CT) predicts outcome in idiopathic pulmonary fibrosis (IPF)
OBJECTIVES: In patients with IPF, this study aimed (i) to examine the relationship between serial change in CT parameters of lung volume and lung function, (ii) to identify the prognostic value of serial change in CT parameters of lung volume, and (iii) to define a threshold for serial change in CT markers of lung volume that optimally captures disease progression. METHODS: Serial CTs were analysed for progressive volume loss or fibrosis progression in 81 IPF patients (66 males, median age = 67 years) with concurrent forced vital capacity (FVC) (median follow-up 12 months, range 6-23 months). Serial CT measurements of volume loss comprised oblique fissure posterior retraction distance (OFPRD), aortosternal distance (ASD), lung height corrected for body habitus (LH), and automated CT-derived total lung volumes (ALV) (measured using commercially available software). Fibrosis progression was scored visually. Serial changes in CT markers and FVC were compared using regression analysis, and evaluated against mortality using Cox proportional hazards. RESULTS: There were 58 deaths (72%, median survival = 17 months). Annual % change in ALV was most significantly related to annual % change in FVC (R2 = 0.26, p < 0.0001). On multivariate analysis, annual % change in ASD predicted mortality (HR = 0.97, p < 0.001), whereas change in FVC did not. A 25% decline in annual % change in ASD best predicted mortality, superior to 10% decline in FVC and fibrosis progression. CONCLUSION: In IPF, serial decline in CT markers of lung volume and, specifically, annualised 25% reduction in aortosternal distance provides evidence of disease progression, not always identified by FVC trends or changes in fibrosis extent. KEY POINTS: • Serial decline in automated and surrogate markers of lung volume on CT corresponds to changes in FVC. • Annualised reductions in the distance between ascending aorta and posterior border of the sternum on CT predict mortality beyond annualised percentage change in FVC
ESC core curriculum for the general cardiologist (2013)
[No abstract available
Mechanistic and pathological study of the genesis, growth, and rupture of abdominal aortic aneurysms
Postprint (published version
A computational framework for generating patient-specific vascular models and assessing uncertainty from medical images
Patient-specific computational modeling is a popular, non-invasive method to
answer medical questions. Medical images are used to extract geometric domains
necessary to create these models, providing a predictive tool for clinicians.
However, in vivo imaging is subject to uncertainty, impacting vessel dimensions
essential to the mathematical modeling process. While there are numerous
programs available to provide information about vessel length, radii, and
position, there is currently no exact way to determine and calibrate these
features. This raises the question, if we are building patient-specific models
based on uncertain measurements, how accurate are the geometries we extract and
how can we best represent a patient's vasculature? In this study, we develop a
novel framework to determine vessel dimensions using change points. We explore
the impact of uncertainty in the network extraction process on hemodynamics by
varying vessel dimensions and segmenting the same images multiple times. Our
analyses reveal that image segmentation, network size, and minor changes in
radius and length have significant impacts on pressure and flow dynamics in
rapidly branching structures and tapering vessels. Accordingly, we conclude
that it is critical to understand how uncertainty in network geometry
propagates to fluid dynamics, especially in clinical applications.Comment: 21 pages, 9 figure
- …