Inducing Mild Traumatic Brain Injury in C. elegans via Cavitation-Free Surface Acoustic Wave-Driven Ultrasonic Irradiation.

Mild traumatic brain injury is an all-too-common outcome from modern warfare and sport, and lacks a reproducible model for assessment of potential treatments and protection against it. Here we consider the use of surface acoustic wave (SAW) irradiation of C. elegans worms-without cavitation-as a potential, ethically reasonable animal-on-a-chip model for inducing traumatic brain injury in an animal, producing significant effects on memory and learning that could prove useful in a model that progress from youth to old age in but a few weeks. We show a significant effect by SAW on the ability of worms to learn post-exposure through associative learning chemotaxis. At higher SAW intensity, we find immediate, thorough, but temporary paralysis of the worms. We further explore the importance of homogeneous exposure of the worms to the SAW-driven ultrasound, an aspect poorly controlled in past efforts, if at all, and demonstrate the absence of cavitation through a change in fluids from a standard media for the worms to the exceedingly viscous polyvinyl alcohol. Likewise, we demonstrate that acoustic streaming, when present, is not directly responsible for paralysis nor learning disabilities induced in the worm, but is beneficial at low amplitudes to ensuring homogeneous ultrasound exposure

EUROPEAN CONFERENCE ON QUEUEING THEORY 2016

International audienceThis booklet contains the proceedings of the second European Conference in Queueing Theory (ECQT) that was held from the 18th to the 20th of July 2016 at the engineering school ENSEEIHT, Toulouse, France. ECQT is a biannual event where scientists and technicians in queueing theory and related areas get together to promote research, encourage interaction and exchange ideas. The spirit of the conference is to be a queueing event organized from within Europe, but open to participants from all over the world. The technical program of the 2016 edition consisted of 112 presentations organized in 29 sessions covering all trends in queueing theory, including the development of the theory, methodology advances, computational aspects and applications. Another exciting feature of ECQT2016 was the institution of the Takács Award for outstanding PhD thesis on "Queueing Theory and its Applications"

Study and analysis of innovative network protocols and architectures

In the last years, some new paradigms are emerging in the networking area as inspiring models for the definition of future communications networks. A key example is certainly the Content Centric Networking (CCN) protocol suite, namely a novel network architecture that aims to supersede the current TCP/IP stack in favor of a name based routing algorithm, also introducing in-network caching capabilities. On the other hand, much interest has been placed on Software Defined Networking (SDN), namely the set of protocols and architectures designed to make network devices more dynamic and programmable. Given this complex arena, the thesis focuses on the analysis of these innovative network protocols, with the aim of exploring possible design flaws and hence guaranteeing their proper operation when actually deployed in the network. Particular emphasis is given to the security of these protocols, for its essential role in every wide scale application. Some work has been done in this direction, but all these solutions are far to be considered fully investigated. In the CCN case, a closer investigation on problems related to possible DDoS attacks due to the stateful nature of the protocol, is presented along with a full-fledged proposal to support scalable PUSH application on top of CCN. Concerning SDN, instead, we present a tool for the verification of network policies in complex graphs containing dynamic network functions. In order to obtain significant results, we leverage different tools and methodologies: on the one hand, we assess simulation software as very useful tools for representing the most common use cases for the various technologies. On the other hand, we exploit more sophisticated formal methods to ensure a higher level of confidence for the obtained results

Nonlinearity and stochasticity in biochemical networks

Recent advances in biology have revolutionized our understanding of living systems. For the first time, it is possible to study the behavior of individual cells. This has led to the discovery of many amazing phenomena. For example, cells have developed intelligent mechanisms for foraging, communicating, and responding to environmental changes. These diverse functions in cells are controlled through biochemical networks consisting of many different proteins and signaling molecules. These molecules interact and affect gene expression, which in turn affects protein production. This results in a complex mesh of feedback and feedforward interactions. These complex networks are generally highly nonlinear and stochastic, making them difficult to study quantitatively. Recent studies have shown that biochemical networks are also highly modular, meaning that different parts of the network do not interact strongly with each other. These modules tend to be conserved across species and serve specific biological functions. However, detect- ing modules and identifying their function tends to be a very difficult task. To overcome some of these complexities, I present an alternative modeling approach that builds quantitative models using coarse-grained biological processes. These coarse-grained models are often stochastic (probabilistic) and highly non-linear. In this thesis, I focus on modeling biochemical networks in two distinct biological systems: Dictyostelium discoideum and microRNAs. Chapters 2 and 3 focus on cellular communication in the social amoebae Dictyostelium discoideum. Using universality, I propose a stochastic nonlinear model that describes the behavior of individual cells and cellular populations. In chapter 4 I study the interaction between messenger RNAs and noncoding RNAs, using Langevin equations

Multistage Packet-Switching Fabrics for Data Center Networks

Recent applications have imposed stringent requirements within the Data Center Network (DCN) switches in terms of scalability, throughput and latency. In this thesis, the architectural design of the packet-switches is tackled in different ways to enable the expansion in both the number of connected endpoints and traffic volume. A cost-effective Clos-network switch with partially buffered units is proposed and two packet scheduling algorithms are described. The first algorithm adopts many simple and distributed arbiters, while the second approach relies on a central arbiter to guarantee an ordered packet delivery. For an improved scalability, the Clos switch is build using a Network-on-Chip (NoC) fabric instead of the common crossbar units. The Clos-UDN architecture made with Input-Queued (IQ) Uni-Directional NoC modules (UDNs) simplifies the input line cards and obviates the need for the costly Virtual Output Queues (VOQs). It also avoids the need for complex, and synchronized scheduling processes, and offers speedup, load balancing, and good path diversity. Under skewed traffic, a reliable micro load-balancing contributes to boosting the overall network performance. Taking advantage of the NoC paradigm, a wrapped-around multistage switch with fully interconnected Central Modules (CMs) is proposed. The architecture operates with a congestion-aware routing algorithm that proactively distributes the traffic load across the switching modules, and enhances the switch performance under critical packet arrivals. The implementation of small on-chip buffers has been made perfectly feasible using the current technology. This motivated the implementation of a large switching architecture with an Output-Queued (OQ) NoC fabric. The design merges assets of the output queuing, and NoCs to provide high throughput, and smooth latency variations. An approximate analytical model of the switch performance is also proposed. To further exploit the potential of the NoC fabrics and their modularity features, a high capacity Clos switch with Multi-Directional NoC (MDN) modules is presented. The Clos-MDN switching architecture exhibits a more compact layout than the Clos-UDN switch. It scales better and faster in port count and traffic load. Results achieved in this thesis demonstrate the high performance, expandability and programmability features of the proposed packet-switches which makes them promising candidates for the next-generation data center networking infrastructure