Chinese Expert Consensus on Critical Care Ultrasound Applications at COVID-19 Pandemic

The spread of new coronavirus (SARS-Cov-2) follows a different pattern than previous respiratory viruses, posing a serious public health risk worldwide. World Health Organization (WHO) named the disease as COVID-19 and declared it a pandemic. COVID-19 is characterized by highly contagious nature, rapid transmission, swift clinical course, profound worldwide impact, and high mortality among critically ill patients. Chest X-ray, computerized tomography (CT), and ultrasound are commonly used imaging modalities. Among them, ultrasound, due to its portability and non-invasiveness, can be easily moved to the bedside for examination at any time. In addition, with use of 4G or 5G networks, remote ultrasound consultation can also be performed, which allows ultrasound to be used in isolated medial areas. Besides, the contact surface of ultrasound probe with patients is small and easy to be disinfected. Therefore, ultrasound has gotten lots of positive feedbacks from the frontline healthcare workers, and it has played an indispensable role in the course of COVID-19 diagnosis and follow up

Space physics missions handbook

The purpose of this handbook is to provide background data on current, approved, and planned missions, including a summary of the recommended candidate future missions. Topics include the space physics mission plan, operational spacecraft, and details of such approved missions as the Tethered Satellite System, the Solar and Heliospheric Observatory, and the Atmospheric Laboratory for Applications and Science

Index to nasa tech briefs, issue number 2

Annotated bibliography on technological innovations in NASA space program

A Budding-Defective M2 Mutant Exhibits Reduced Membrane Interaction, Insensitivity To Cholesterol, And Perturbed Interdomain Coupling

Influenza A M2 is a membrane-associated protein with a C-terminal amphipathic helix that plays a cholesterol-dependent role in viral budding. An M2 mutant with alanine substitutions in the C-terminal amphipathic helix is deficient in viral scission. With the goal of providing atomic-level understanding of how the wild-type protein functions, we used a multipronged site-directed spin labeling electron paramagnetic resonance spectroscopy (SDSL-EPR) approach to characterize the conformational properties of the alanine mutant. We spin-labeled sites in the transmembrane (TM) domain and the C-terminal amphipathic helix (AH) of wild-type (WT) and mutant M2, and collected information on line shapes, relaxation rates, membrane topology, and distances within the homotetramer in membranes with and without cholesterol. Our results identify marked differences in the conformation and dynamics between the WT and the alanine mutant. Compared to WT, the dominant population of the mutant AH is more dynamic, shallower in the membrane, and has altered quaternary arrangement of the C-terminal domain. While the AH becomes more dynamic, the dominant population of the TM domain of the mutant is immobilized. The presence of cholesterol changes the conformation and dynamics of the WT protein, while the alanine mutant is insensitive to cholesterol. These findings provide new insight into how M2 may facilitate budding. We propose the AH–membrane interaction modulates the arrangement of the TM helices, effectively stabilizing a conformational state that enables M2 to facilitate viral budding. Antagonizing the properties of the AH that enable interdomain coupling within M2 may therefore present a novel strategy for anti-influenza drug design

Non-Equilibrium Processes in the Solar Corona, Transition Region, Flares, and Solar Wind \textit{(Invited Review)}

We review the presence and signatures of the non-equilibrium processes, both non-Maxwellian distributions and non-equilibrium ionization, in the solar transition region, corona, solar wind, and flares. Basic properties of the non-Maxwellian distributions are described together with their influence on the heat flux as well as on the rates of individual collisional processes and the resulting optically thin synthetic spectra. Constraints on the presence of high-energy electrons from observations are reviewed, including positive detection of non-Maxwellian distributions in the solar corona, transition region, flares, and wind. Occurrence of non-equilibrium ionization is reviewed as well, especially in connection to hydrodynamic and generalized collisional-radiative modelling. Predicted spectroscopic signatures of non-equilibrium ionization depending on the assumed plasma conditions are summarized. Finally, we discuss the future remote-sensing instrumentation that can be used for detection of these non-equilibrium phenomena in various spectral ranges.Comment: Solar Physics, accepte

Galileo to Jupiter: Probing the Planet and Mapping Its Moons

The first project to use the space shuttle as an interplanetary launch vehicle, the Galileo mission is designed to obtain information about the origin and evolution of the solar system by studying large-scale phenomena on Jupiter and its satellites. Aimed towards Mars to obtain gravity assist, the orbiting spacecraft will deploy a probe, which penetrating the Jovian atmosphere, will transmit data for approximately an hour. The spacecraft itself will inspect the atmospheres, ionospheres, and surfaces of Ganymede, Io, Europa, and Callisto, as well as determine their magnetic and gravitational properties. The experiments to be conducted and their scientific objectives are described. Known facts about the Jovian system are reviewed

Diffuse polarized emission associated with the Perseus cluster

We report on full-polarization radio observations of the Perseus cluster (Abell 426) using the Westerbork Synthesis Radio Telescope (WSRT) at wavelengths from 81-95 cm. We have employed a novel technique, Rotation Measure synthesis (Brentjens and de Bruyn, 2005) to unravel the polarization properties of the emission across the full field of view and detect polarized emission over a wide range of RM from about 0 to 90 rad m^-2. The low RM emission is associated with our Galaxy, while the high RM emission is associated with the Perseus cluster. The latter reaches typical surface brightness levels of 0.5-1 mJy per beam and must be rather highly polarized. Most of the peripheral polarized emission appears too bright, by about 1-2 orders of magnitude, to be explainable as Thomson scattered emission of the central radio source off the thermal electrons in the cluster. The bulk of the emission associated with the Perseus cluster is probably related to buoyant bubbles of relativistic plasma, probably relics from still active or now dormant AGN within the cluster. A lenticular shaped structure measuring 0.5-1 Mpc is strikingly similar to the structures predicted by Ensslin et al. (1998). At the western edge of the cluster, we detect very long, linear structures that may be related to shocks caused by infall of gas into the Perseus cluster.Comment: 18 pages, 17 figures, accepted by A&A, corrected small typo, added referenc