Neuromorphic Neuromodulation: Towards the next generation of on-device AI-revolution in electroceuticals

Neuromodulation techniques have emerged as promising approaches for treating a wide range of neurological disorders, precisely delivering electrical stimulation to modulate abnormal neuronal activity. While leveraging the unique capabilities of artificial intelligence (AI) holds immense potential for responsive neurostimulation, it appears as an extremely challenging proposition where real-time (low-latency) processing, low power consumption, and heat constraints are limiting factors. The use of sophisticated AI-driven models for personalized neurostimulation depends on back-telemetry of data to external systems (e.g. cloud-based medical mesosystems and ecosystems). While this can be a solution, integrating continuous learning within implantable neuromodulation devices for several applications, such as seizure prediction in epilepsy, is an open question. We believe neuromorphic architectures hold an outstanding potential to open new avenues for sophisticated on-chip analysis of neural signals and AI-driven personalized treatments. With more than three orders of magnitude reduction in the total data required for data processing and feature extraction, the high power- and memory-efficiency of neuromorphic computing to hardware-firmware co-design can be considered as the solution-in-the-making to resource-constraint implantable neuromodulation systems. This could lead to a new breed of closed-loop responsive and personalised feedback, which we describe as Neuromorphic Neuromodulation. This can empower precise and adaptive modulation strategies by integrating neuromorphic AI as tightly as possible to the site of the sensors and stimulators. This paper presents a perspective on the potential of Neuromorphic Neuromodulation, emphasizing its capacity to revolutionize implantable brain-machine microsystems and significantly improve patient-specificity.Comment: 17 page

Supervised learning in Spiking Neural Networks with Limited Precision: SNN/LP

A new supervised learning algorithm, SNN/LP, is proposed for Spiking Neural Networks. This novel algorithm uses limited precision for both synaptic weights and synaptic delays; 3 bits in each case. Also a genetic algorithm is used for the supervised training. The results are comparable or better than previously published work. The results are applicable to the realization of large scale hardware neural networks. One of the trained networks is implemented in programmable hardware.Comment: 7 pages, originally submitted to IJCNN 201

An Enhanced Automated Epileptic Seizure Detection Using ANFIS, FFA and EPSO Algorithms

Objectives: Electroencephalogram (EEG) signal   gives   a   viable perception about the neurological action of the human brain that aids the detection of epilepsy. The objective of this study is to build an accurate automated hybrid model for epileptic seizure detection. Methods: This work develops a computer-aided diagnosis (CAD) machine learning model which can spontaneously classify pre-ictal and ictal EEG signals. In the proposed method two most effective nature inspired algorithms, Firefly algorithm (FFA) and Efficient Particle Swarm Optimization (EPSO) are used to determine the optimum parameters of Adaptive Neuro Fuzzy Inference System (ANFIS) network. Results: Compared to the FFA and EPSO algorithm separately, the composite (ANFIS+FFA+EPSO) optimization algorithm outperforms in all respects. The proposed technique achieved accuracy, specificity, and sensitivity of 99.87%, 98.71% and 100% respectively. Conclusion: The ANFIS-FFA-EPSO method is able to enhance the seizure detection outcomes for demand forecast in hospital

Brain Disease Detection From EEGS: Comparing Spiking and Recurrent Neural Networks for Non-stationary Time Series Classification

Modeling non-stationary time series data is a difficult problem area in AI, due to the fact that the statistical properties of the data change as the time series progresses. This complicates the classification of non-stationary time series, which is a method used in the detection of brain diseases from EEGs. Various techniques have been developed in the field of deep learning for tackling this problem, with recurrent neural networks (RNN) approaches utilising Long short-term memory (LSTM) architectures achieving a high degree of success. This study implements a new, spiking neural network-based approach to time series classification for the purpose of detecting three brain diseases from EEG datasets - epilepsy, alcoholism, and schizophrenia. The performance and training time of the spiking neural network classifier is compared to those of both a baseline RNN-LSTM EEG classifier and the current state-of-the art RNN-LSTM EEG classifier architecture from the relevant literature. The SNN EEG classifier model developed in this study outperforms both the baseline and state of-the-art RNN models in terms of accuracy, and is able to detect all three brain diseases with an accuracy of 100%, while requiring a far smaller number of training data samples than recurrent neural network approaches. This represents the best performance present in the literature for the task of EEG classificatio

DEVELOPMENT OF AN ACCURATE SEIZURE DETECTION SYSTEM USING RANDOM FOREST CLASSIFIER WITH ICA BASED ARTIFACT REMOVAL ON EEG DATA

Abstract The creation of a reliable artifact removal and precise epileptic seizure identification system using Seina Scalp EEG data and cutting-edge machine learning techniques is presented in this paper. Random Forest classifier used for seizure classification, and independent component analysis (ICA) is used for artifact removal. Various artifacts, such as eye blinks, muscular activity, and environmental noise, are successfully recognized and removed from the EEG signals using ICA-based artifact removal, increasing the accuracy of the analysis that comes after. A precise distinction between seizure and non-seizure segments is made possible by the Random Forest Classifier, which was created expressly to capture the spatial and temporal patterns associated with epileptic seizures. Experimental evaluation of the Seina Scalp EEG Data demonstrates the excellent accuracy of our approach, achieving a 96% seizure identification rate A potential strategy for improving the accuracy and clinical utility of EEG-based epilepsy diagnosis is the merging of modern signal processing methods and deep learning algorithms

Massively-parallel bit-serial neural networks for fast epilepsy diagnosis: a feasibility study

There are about 1% of the world population suffering from the hidden disability known as epilepsy and major developing countries are not fully equipped to counter this problem. In order to reduce the inconvenience and danger of epilepsy, different methods have been researched by using a artificial neural network (ANN) classification to distinguish epileptic waveforms from normal brain waveforms. This paper outlines the aim of achieving massive ANN parallelization through a dedicated hardware using bit-serial processing. The design of this bit-serial Neural Processing Element (NPE) is presented which implements the functionality of a complete neuron using variable accuracy. The proposed design has been tested taking into consideration non-idealities of a hardware ANN. The NPE consists of a bit-serial multiplier which uses only 16 logic elements on an Altera Cyclone IV FPGA and a bit-serial ALU as well as a look-up table. Arrays of NPEs can be driven by a single controller which executes the neural processing algorithm. In conclusion, the proposed compact NPE design allows the construction of complex hardware ANNs that can be implemented in a portable equipment that suits the needs of a single epileptic patient in his or her daily activities to predict the occurrences of impending tonic conic seizures

A Fuzzy Logic System for Seizure Onset Detection in Intracranial EEG

We present a multistage fuzzy rule-based algorithm for epileptic seizure onset detection. Amplitude, frequency, and entropy-based features were extracted from intracranial electroencephalogram (iEEG) recordings and considered as the inputs for a fuzzy system. These features extracted from multichannel iEEG signals were combined using fuzzy algorithms both in feature domain and in spatial domain. Fuzzy rules were derived based on experts' knowledge and reasoning. An adaptive fuzzy subsystem was used for combining characteristics features extracted from iEEG. For the spatial combination, three channels from epileptogenic zone and one from remote zone were considered into another fuzzy subsystem. Finally, a threshold procedure was applied to the fuzzy output derived from the final fuzzy subsystem. The method was evaluated on iEEG datasets selected from Freiburg Seizure Prediction EEG (FSPEEG) database. A total of 112.45 hours of intracranial EEG recordings was selected from 20 patients having 56 seizures was used for the system performance evaluation. The overall sensitivity of 95.8% with false detection rate of 0.26 per hour and average detection latency of 15.8 seconds was achieved