2,594 research outputs found
Applicability of semi-supervised learning assumptions for gene ontology terms prediction
Gene Ontology (GO) is one of the most important resources in bioinformatics, aiming to provide a unified framework for the biological annotation of genes and proteins across all species. Predicting GO terms is an essential task for bioinformatics, but the number of available labelled proteins is in several cases insufficient for training reliable machine learning classifiers. Semi-supervised learning methods arise as a powerful solution that explodes the information contained in unlabelled data in order to improve the estimations of traditional supervised approaches. However, semi-supervised learning methods have to make strong assumptions about the nature of the training data and thus, the performance of the predictor is highly dependent on these assumptions. This paper presents an analysis of the applicability of semi-supervised learning assumptions over the specific task of GO terms prediction, focused on providing judgment elements that allow choosing the most suitable tools for specific GO terms. The results show that semi-supervised approaches significantly outperform the traditional supervised methods and that the highest performances are reached when applying the cluster assumption. Besides, it is experimentally demonstrated that cluster and manifold assumptions are complimentary to each other and an analysis of which GO terms can be more prone to be correctly predicted with each assumption, is provided.Postprint (published version
A review of multi-instance learning assumptions
Multi-instance (MI) learning is a variant of inductive machine learning, where each learning example contains a bag of instances instead of a single feature vector. The term commonly refers to the supervised setting, where each bag is associated with a label. This type of representation is a natural fit for a number of real-world learning scenarios, including drug activity prediction and image classification, hence many MI learning algorithms have been proposed. Any MI learning method must relate instances to bag-level class labels, but many types of relationships between instances and class labels are possible. Although all early work in MI learning assumes a specific MI concept class known to be appropriate for a drug activity prediction domain; this âstandard MI assumptionâ is not guaranteed to hold in other domains. Much of the recent work in MI learning has concentrated on a relaxed view of the MI problem, where the standard MI assumption is dropped, and alternative assumptions are considered instead. However, often it is not clearly stated what particular assumption is used and how it relates to other assumptions that have been proposed. In this paper, we aim to clarify the use of alternative MI assumptions by reviewing the work done in this area
Dissimilarity-based Ensembles for Multiple Instance Learning
In multiple instance learning, objects are sets (bags) of feature vectors
(instances) rather than individual feature vectors. In this paper we address
the problem of how these bags can best be represented. Two standard approaches
are to use (dis)similarities between bags and prototype bags, or between bags
and prototype instances. The first approach results in a relatively
low-dimensional representation determined by the number of training bags, while
the second approach results in a relatively high-dimensional representation,
determined by the total number of instances in the training set. In this paper
a third, intermediate approach is proposed, which links the two approaches and
combines their strengths. Our classifier is inspired by a random subspace
ensemble, and considers subspaces of the dissimilarity space, defined by
subsets of instances, as prototypes. We provide guidelines for using such an
ensemble, and show state-of-the-art performances on a range of multiple
instance learning problems.Comment: Submitted to IEEE Transactions on Neural Networks and Learning
Systems, Special Issue on Learning in Non-(geo)metric Space
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