Application of Mahalanobis-Taguchi System in Full Blood Count of Methadone Flexi Dispensing Program

Patient under methadone flexi dispensing (MFlex) program are required to do blood tests like full blood count (FBC). A doctor assesses 3 parameters like haemoglobin, platelet count, and fasting blood sugar to ensure the patient has FBC problem. Consequently, the existing system does not have a stable ecosystem towards classification and optimization. The objective is to apply Mahalanobis-Taguchi system (MTS) in the MFlex program. The data is collected at Bandar Pekan clinic with 34 parameters. Two types of MTS methods are used like RT-Method and T-Method for classification and optimization respectively. The average Mahalanobis distance (MD) of healthy is 1.0000 and unhealthy is 187.0555. Positive degree of contribution has 19 parameters. 15 unknown samples have been diagnosed. Type 5 of 6 modifications has been selected as the best proposed solution. In conclusion, a pharmacist from Bandar Pekan clinic confirmed that MTS able to solve problem in classification and optimization of MFlex program

Data-based ensemble approach for semi-supervised anomaly detection in machine tool condition monitoring

Data-based methods are capable to monitor machine components. Approaches for semi-supervised anomaly detection are trained using sensor data that describe the normal state of machine components. Thus, such approaches are interesting for industrial practice, since sensor data do not have to be labeled in a time-consuming and costly way. In this work, an ensemble approach for semi-supervised anomaly detection is used to detect anomalies. It is shown that the ensemble approach is suitable for condition monitoring of ball screws. For the evaluation of the approach, a data set of a regular test cycle of a ball screw from automotive industry is used

A proposal of a technique for correlating defect dimensions to vibration amplitude in bearing monitoring

The capability of early stage detection of a defect is gaining more and more importance because it can help the maintenance process, the cost reduction and the reliability of the systems. The increment of vibration amplitude is a well-known method for evaluating the damage of a component, but it is sometimes difficult to understand the exact level of damage. In other words, the amplitude of vibration cannot be directly connected to the dimension of the defect. In the present paper, based on a non-Hertzian contact algorithm, the spectrum of the pressure distribution in the contact surface between the race and the rolling element is evaluated. Such spectrum is then compared with the acquired spectrum of a vibration response of a defected bearing. The bearing vibration pattern was previously analyzed with monitoring techniques to extract all the damage information. The correlation between the spectrum of the pressure distribution in the defected contact surface and the analyzed spectrum of the damaged bearing highlights a strict relationship. By using that analysis, a precise correlation between defect aspect and dimension and vibration level can be addressed to estimate the level of damaging

Friction, Vibration and Dynamic Properties of Transmission System under Wear Progression

This reprint focuses on wear and fatigue analysis, the dynamic properties of coating surfaces in transmission systems, and non-destructive condition monitoring for the health management of transmission systems. Transmission systems play a vital role in various types of industrial structure, including wind turbines, vehicles, mining and material-handling equipment, offshore vessels, and aircrafts. Surface wear is an inevitable phenomenon during the service life of transmission systems (such as on gearboxes, bearings, and shafts), and wear propagation can reduce the durability of the contact coating surface. As a result, the performance of the transmission system can degrade significantly, which can cause sudden shutdown of the whole system and lead to unexpected economic loss and accidents. Therefore, to ensure adequate health management of the transmission system, it is necessary to investigate the friction, vibration, and dynamic properties of its contact coating surface and monitor its operating conditions

Quantitative Risk Analysis using Real-time Data and Change-point Analysis for Data-informed Risk Prediction

Incidents in highly hazardous process industries (HHPI) are a major concern for various stakeholders due to the impact on human lives, environment, and potentially huge financial losses. Because process activities, location and products are unique, risk analysis techniques applied in the HHPI has evolved over the years. Unfortunately, some limitations of the various quantitative risk analysis (QRA) method currently employed means alternative or more improved methods are required. This research has obtained one such method called Big Data QRA Method. This method relies entirely on big data techniques and real-time process data to identify the point at which process risk is imminent and provide the extent of contribution of other components interacting up to the time index of the risk. Unlike the existing QRA methods which are static and based on unvalidated assumptions and data from single case studies, the big data method is dynamic and can be applied to most process systems. This alternative method is my original contribution to science and the practice of risk analysis The detailed procedure which has been provided in Chapter 9 of this thesis applies multiple change-point analysis and other big data techniques like, (a) time series analysis, (b) data exploration and compression techniques, (c) decision tree modelling, (d) linear regression modelling. Since the distributional properties of process data can change over time, the big data approach was found to be more appropriate. Considering the unique conditions, activities and the process systems use within the HHPI, the dust fire and explosion incidents at the Imperial Sugar Factory and the New England Wood Pellet LLC both of which occurred in the USA were found to be suitable case histories to use as a guide for evaluation of data in this research. Data analysis was performed using open source software packages in R Studio. Based on the investigation, multiple-change-point analysis packages strucchange and changepoint were found to be successful at detecting early signs of deteriorating conditions of component in process equipment and the main process risk. One such process component is a bearing which was suspected as the source of ignition which led to the dust fire and explosion at the Imperial Sugar Factory. As a result, this this research applies the big data QRA method procedure to bearing vibration data to predict early deterioration of bearings and final period when the bearing’s performance begins the final phase of deterioration to failure. Model-based identification of these periods provides an indication of whether the conditions of a mechanical part in process equipment at a particular moment represent an unacceptable risk. The procedure starts with selection of process operation data based on the findings of an incident investigation report on the case history of a known process incident. As the defining components of risk, both the frequency and consequences associated with the risk were obtained from the incident investigation reports. Acceptance criteria for the risk can be applied to the periods between the risks detected by the two change-point packages. The method was validated with two case study datasets to demonstrate its applicability as procedure for QRA. The procedure was then tested with two other case study datasets as examples of its application as a QRA method. The insight obtained from the validation and the applied examples led to the conclusion that big data techniques can be applied to real-time process data for risk assessment in the HHPI

Sample Preparation in Metabolomics

Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution μ magic-angle spinning nuclear magnetic resonance (HR-μMAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees

Computing Intelligence Technique and Multiresolution Data Processing for Condition Monitoring

Condition monitoring (CM) of rotary machines has gained increasing importance and extensive research in recent years. Due to the rapid growth of data volume, automated data processing is necessary in order to deal with massive data efficiently to produce timely and accurate diagnostic results. Artificial intelligence (AI) and adaptive data processing approaches can be promising solutions to the challenge of large data volume. Unfortunately, the majority of AI-based techniques in CM have been developed for only the post-processing (classification) stage, whereas the critical tasks including feature extraction and selection are still manually processed, which often require considerable time and efforts but also yield a performance depending on prior knowledge and diagnostic expertise. To achieve an automatic data processing, the research of this PhD project provides an integrated framework with two main approaches. Firstly, it focuses on extending AI techniques in all phases, including feature extraction by applying Componential Coding Neural Network (CCNN) which has been found to have unique properties of being trained through unsupervised learning, capable of dealing with raw datasets, translation invariance and high computational efficiency. These advantages of CCNN make it particularly suitable for automated analyzing of the vibration data arisen from typical machine components such as the rolling element bearings which exhibit periodic phenomena with high non-stationary and strong noise contamination. Then, once an anomaly is detected, a further analysis technique to identify the fault is proposed using a multiresolution data analysis approach based on Double-Density Discrete Wavelet Transform (DD-DWT) which was grounded on over-sampled filter banks with smooth tight frames. This makes it nearly shift-invariant which is important for extracting non-stationary periodical peaks. Also, in order to denoise and enhance the diagnostic features, a novel level-dependant adaptive thresholding method based on harmonic to signal ratio (HSR) is developed and implemented on the selected wavelet coefficients. This method has been developed to be a semi-automated (adaptive) approach to facilitate the process of fault diagnosis. The developed framework has been evaluated using both simulated and measured datasets from typical healthy and defective tapered roller bearings which are critical parts of all rotating machines. The results have demonstrated that the CCNN is a robust technique for early fault detection, and also showed that adaptive DD-DWT is a robust technique for diagnosing the faults induced to test bearings. The developed framework has achieved multi-objectives of high detection sensitivity, reliable diagnosis and minimized computing complexity

Mastering Uncertainty in Mechanical Engineering

This open access book reports on innovative methods, technologies and strategies for mastering uncertainty in technical systems. Despite the fact that current research on uncertainty is mainly focusing on uncertainty quantification and analysis, this book gives emphasis to innovative ways to master uncertainty in engineering design, production and product usage alike. It gathers authoritative contributions by more than 30 scientists reporting on years of research in the areas of engineering, applied mathematics and law, thus offering a timely, comprehensive and multidisciplinary account of theories and methods for quantifying data, model and structural uncertainty, and of fundamental strategies for mastering uncertainty. It covers key concepts such as robustness, flexibility and resilience in detail. All the described methods, technologies and strategies have been validated with the help of three technical systems, i.e. the Modular Active Spring-Damper System, the Active Air Spring and the 3D Servo Press, which have been in turn developed and tested during more than ten years of cooperative research. Overall, this book offers a timely, practice-oriented reference guide to graduate students, researchers and professionals dealing with uncertainty in the broad field of mechanical engineering