Optimal management of bio-based energy supply chains under parametric uncertainty through a data-driven decision-support framework

This paper addresses the optimal management of a multi-objective bio-based energy supply chain network subjected to multiple sources of uncertainty. The complexity to obtain an optimal solution using traditional uncertainty management methods dramatically increases with the number of uncertain factors considered. Such a complexity produces that, if tractable, the problem is solved after a large computational effort. Therefore, in this work a data-driven decision-making framework is proposed to address this issue. Such a framework exploits machine learning techniques to efficiently approximate the optimal management decisions considering a set of uncertain parameters that continuously influence the process behavior as an input. A design of computer experiments technique is used in order to combine these parameters and produce a matrix of representative information. These data are used to optimize the deterministic multi-objective bio-based energy network problem through conventional optimization methods, leading to a detailed (but elementary) map of the optimal management decisions based on the uncertain parameters. Afterwards, the detailed data-driven relations are described/identified using an Ordinary Kriging meta-model. The result exhibits a very high accuracy of the parametric meta-models for predicting the optimal decision variables in comparison with the traditional stochastic approach. Besides, and more importantly, a dramatic reduction of the computational effort required to obtain these optimal values in response to the change of the uncertain parameters is achieved. Thus the use of the proposed data-driven decision tool promotes a time-effective optimal decision making, which represents a step forward to use data-driven strategy in large-scale/complex industrial problems.Peer ReviewedPostprint (published version

Stock Management in Hospital Pharmacy using Chance-Constrained Model Predictive Control

One of the most important problems in the pharmacy department of a hospital is stock management. The clinical need for drugs must be satisfied with limited work labor while minimizing the use of economic resources. The complexity of the problem resides in the random nature of the drug demand and the multiple constraints that must be taken into account in every decision. In this article, chance-constrained model predictive control is proposed to deal with this problem. The flexibility of model predictive control allows taking into account explicitly the different objectives and constraints involved in the problem while the use of chance constraints provides a trade-off between conservativeness and efficiency. The solution proposed is assessed to study its implementation in two Spanish hospitals.Junta de Andalucía P12-TIC-240

Inventory drivers in a pharmaceutical supply chain

In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent markets-, high service levels, and complex, perishable finished-good portfolios, which makes keeping reasonable amounts of stock a true challenge. However, a one-way strategy towards zero-inventory is in reality inapplicable, due to the strategic nature and importance of the products being commercialised. Therefore, pharmaceutical supply chains are in need of new inventory strategies in order to remain competitive. Finished-goods inventory management in the pharmaceutical industry is closely related to the manufacturing systems and supply chain configurations that companies adopt. The factors considered in inventory management policies, however, do not always cover the full supply chain spectrum in which companies operate. This paper works under the pre-assumption that, in fact, there is a complex relationship between the inventory configurations that companies adopt and the factors behind them. The intention of this paper is to understand the factors driving high finished-goods inventory levels in pharmaceutical supply chains and assist supply chain managers in determining which of them can be influenced in order to reduce inventories to an optimal degree. Reasons for reducing inventory levels are found in high inventory holding and scrap related costs; in addition to lost sales for not being able to serve the customers with the adequate shelf life requirements. The thesis conducts a single case study research in a multi-national pharmaceutical company, which is used to examine typical inventory configurations and the factors affecting these configurations. This paper presents a framework that can assist supply chain managers in determining the most important inventory drivers in pharmaceutical supply chains. The findings in this study suggest that while external and downstream supply chain factors are recognized as being critical to pursue inventory optimization initiatives, pharmaceutical companies are oriented towards optimizing production processes and meeting regulatory requirements while still complying with high service levels, being internal factors the ones prevailing when making inventory management decisions. Furthermore, this paper investigates, through predictive modelling techniques, how various intrinsic and extrinsic factors influence the inventory configurations of the case study company. The study shows that inventory configurations are relatively unstable over time, especially in configurations that present high safety stock levels; and that production features and product characteristics are important explanatory factors behind high inventory levels. Regulatory requirements also play an important role in explaining the high strategic inventory levels that pharmaceutical companies hold

Reliability-based economic model predictive control for generalized flow-based networks including actuators' health-aware capabilities

This paper proposes a reliability-based economic model predictive control (MPC) strategy for the management of generalized flow-based networks, integrating some ideas on network service reliability, dynamic safety stock planning, and degradation of equipment health. The proposed strategy is based on a single-layer economic optimisation problem with dynamic constraints, which includes two enhancements with respect to existing approaches. The first enhancement considers chance-constraint programming to compute an optimal inventory replenishment policy based on a desired risk acceptability level, leading to dynamically allocate safety stocks in flow-based networks to satisfy non-stationary flow demands. The second enhancement computes a smart distribution of the control effort and maximises actuators’ availability by estimating their degradation and reliability. The proposed approach is illustrated with an application of water transport networks using the Barcelona network as the considered case study.Peer ReviewedPostprint (author's final draft

The Future of Retail Operations

Retailing consists of all the activities associated with the selling of goods to the final consumer. In this article, we review the research on retail operations published in Manufacturing & Service Operations Research (M&SOM) since 1999. We then discuss the current retail landscape and the new research directions it offers, in which M&SOM can play a prominent role

An assessment of the load modifying potential of model predictive controlled dynamic facades within the California context

California is making major strides towards meeting its greenhouse gas emission reduction goals with the transformation of its electrical grid to accommodate renewable generation, aggressive promotion of building energy efficiency, and increased emphasis on moving toward electrification of end uses (e.g., residential heating, etc.). As a result of this activity, the State is faced with significant challenges of systemwide resource adequacy, power quality and grid reliability that could be addressed in part with demand responsive (DR) load modifying strategies using controllable building technologies. Dynamic facades have the ability to potentially shift and shed loads at critical times of the day in combination with daylighting and HVAC controls. This study explores the technical potential of dynamic facades to support net load shape objectives. A model predictive controller (MPC) was designed based on reduced order thermal (Modelica) and window (Radiance) models. Using an automated workflow (involving JModelica.org and MPCPy), these models were converted and differentiated to formulate a non-linear optimization problem. A gradient-based, non-linear programming problem solver (IPOPT) was used to derive an optimal control strategy, then a post-optimization step was used to convert the solution to a discrete state for facade actuation. Continuous state modulation of the façade was also modeled. The performance of the MPC controller with and without activation of thermal mass was evaluated in a south-facing perimeter office zone with a three-zone electrochromic window for a clear sunny week during summer and winter periods in Oakland and Burbank, California. MPC strategies reduced total energy cost by 9–28% and critical coincident peak demand was reduced by up to 0.58 W/ft2-floor or 19–43% in the 4.6 m (15 ft) deep south zone on sunny summer days in Oakland compared to state-of-the-art heuristic control. Similar savings were achieved for the hotter, Burbank climate in Southern California. This outcome supports the argument that MPC control of dynamic facades can provide significant electricity cost reductions and net load management capabilities of benefit to both the building owner and evolving electrical grid

How do top- and bottom-performing companies differ in using business analytics?

Purpose Business analytics (BA) has attracted growing attention mainly due to the phenomena of big data. While studies suggest that BA positively affects organizational performance, there is a lack of academic research. The purpose of this paper, therefore, is to examine the extent to which top- and bottom-performing companies differ regarding their use and organizational facilitation of BA. Design/methodology/approach Hypotheses are developed drawing on the information processing view and contingency theory, and tested using multivariate analysis of variance to analyze data collected from 117 UK manufacture companies. Findings Top- and bottom-performing companies differ significantly in their use of BA, data-driven environment, and level of fit between BA and data-drain environment. Practical implications Extensive use of BA and data-driven decisions will lead to superior firm performance. Companies wishing to use BA to improve decision making and performance need to develop relevant analytical strategy to guide BA activities and design its structure and business processes to embed BA activities. Originality/value This study provides useful management insights into the effective use of BA for improving organizational performance

An optimal-control based integrated model of supply chain

Problems of supply chain scheduling are challenged by high complexity, combination of continuous and discrete processes, integrated production and transportation operations as well as dynamics and resulting requirements for adaptability and stability analysis. A possibility to address the above-named issues opens modern control theory and optimal program control in particular. Based on a combination of fundamental results of modern optimal program control theory and operations research, an original approach to supply chain scheduling is developed in order to answer the challenges of complexity, dynamics, uncertainty, and adaptivity. Supply chain schedule generation is represented as an optimal program control problem in combination with mathematical programming and interpreted as a dynamic process of operations control within an adaptive framework. The calculation procedure is based on applying Pontryagin’s maximum principle and the resulting essential reduction of problem dimensionality that is under solution at each instant of time. With the developed model, important categories of supply chain analysis such as stability and adaptability can be taken into consideration. Besides, the dimensionality of operations research-based problems can be relieved with the help of distributing model elements between an operations research (static aspects) and a control (dynamic aspects) model. In addition, operations control and flow control models are integrated and applicable for both discrete and continuous processes.supply chain, model of supply chain scheduling, optimal program control theory, Pontryagin’s maximum principle, operations research model,