An Approach for the Development of Complex Systems Archetypes

The purpose of this research is to explore the principles and concepts of systems theory in pursuit of a collection of complex systems archetypes that can be used for system exploration and diagnostics. The study begins with an examination of the archetypes and classification systems that already exist in the domain of systems theory. This review includes a critique of their purpose, structure, and general applicability. The research then develops and employs a new approach to grounded theory, using a visual coding model to explore the origins, relationships, and meanings of the principles of systems theory. The goal of the visual grounded theory approach is to identity underlying, recurrent imagery in the systems literature that will form the basis for the archetypes. Using coding models derived from the literature, the study then examines the interrelationships between system principles. These relationships are used to clearly define the environment where the archetypes are found in terms of energy, entropy and time. A collection of complex system archetypes is then derived which are firmly rooted in the literature, as well as being demonstrably manifested in the real world. The definitions of the emerging complex systems archetypes are consistent with the environmental definition and are governed by the system’s behavior related to energy collection, entropy displacement, and the pursuit of viability. Once the archetypes have been identified, this study examines the similarities and differences that distinguish them. The individual system principles that either define or differentiate each of the archetypes are described, and real-world manifestations of the archetypes are discussed. The collection of archetypes is then examined as a continuum, where they are related to one another in terms of energy use, entropy accumulation, self-modification and external-modification. To illustrate the applicability of these archetypes, a case study is undertaken which examines a medium-sized organization with multiple departments in an industrial setting. The individual departments are discussed in detail, and their archetypical forms are identified and described. Finally, the study examines future applications for the archetypes and other research that might enhance their utility for complex systems governance

Quantitative analyses in basic, translational and clinical biomedical research: metabolism, vaccine design and preterm delivery prediction

2 t.There is nothing more important than preserving life, and the thesis here presented is framed in the field of quantitative biomedicine (or systems biomedicine), which has as objective the application of physico-mathematical techniques in biomedical research in order to enhance the understanding of life's basis and its pathologies, and, ultimately, to defend human health. In this thesis, we have applied physico-mathematical methods in the three fundamental levels of Biomedical Research: basic, translational and clinical. At a basic level, since all pathologies have their basis in the cell, we have performed two studies to deepen in the understanding of the cellular metabolic functionality. In the first work, we have quantitatively analyzed for the first time calcium-dependent chloride currents inside the cell, which has revealed the existence of a dynamical structure characterized by highly organized data sequences, non-trivial long-term correlation that last in average 7.66 seconds, and "crossover" effect with transitions between persistent and anti-persistent behaviors. In the second investigation, by the use of delay differential equations, we have modeled the adenylate energy system, which is the principal source of cellular energy. This study has shown that the cellular energy charge is determined by an oscillatory non-stationary invariant function, bounded from 0.7 to 0.95. At a translational level, we have developed a new method for vaccine design that, besides obtaining high coverages, is capable of giving protection against viruses with high mutability rates such as HIV, HCV or Influenza. Finally, at a clinical level, first we have proven that the classic quantitative measure of uterine contractions (Montevideo Units) is incapable of predicting preterm labor immediacy. Then, by applying autoregressive techniques, we have designed a novel tool for premature delivery forecasting, based only in 30 minutes of uterine dynamics. Altogether, these investigations have originated four scientific publications, and as far as we know, our work is the first European thesis which integrates in the same framework the application of mathematical knowledge to biomedical fields in the three main stages of Biomedical Research: basic, translational and clinical

Propagation of Acoustic Waves Caused by the Accelerations of Vibrating Hand-Held Tools in Viscoelastic Soft Tissues of Human Hands and a Mechanobiological Picture for the Related Injuries

International audienc

Quantitative analyses in basic, translational and clinical biomedical research: metabolism, vaccine design and preterm delivery prediction

2 t.There is nothing more important than preserving life, and the thesis here presented is framed in the field of quantitative biomedicine (or systems biomedicine), which has as objective the application of physico-mathematical techniques in biomedical research in order to enhance the understanding of life's basis and its pathologies, and, ultimately, to defend human health. In this thesis, we have applied physico-mathematical methods in the three fundamental levels of Biomedical Research: basic, translational and clinical. At a basic level, since all pathologies have their basis in the cell, we have performed two studies to deepen in the understanding of the cellular metabolic functionality. In the first work, we have quantitatively analyzed for the first time calcium-dependent chloride currents inside the cell, which has revealed the existence of a dynamical structure characterized by highly organized data sequences, non-trivial long-term correlation that last in average 7.66 seconds, and "crossover" effect with transitions between persistent and anti-persistent behaviors. In the second investigation, by the use of delay differential equations, we have modeled the adenylate energy system, which is the principal source of cellular energy. This study has shown that the cellular energy charge is determined by an oscillatory non-stationary invariant function, bounded from 0.7 to 0.95. At a translational level, we have developed a new method for vaccine design that, besides obtaining high coverages, is capable of giving protection against viruses with high mutability rates such as HIV, HCV or Influenza. Finally, at a clinical level, first we have proven that the classic quantitative measure of uterine contractions (Montevideo Units) is incapable of predicting preterm labor immediacy. Then, by applying autoregressive techniques, we have designed a novel tool for premature delivery forecasting, based only in 30 minutes of uterine dynamics. Altogether, these investigations have originated four scientific publications, and as far as we know, our work is the first European thesis which integrates in the same framework the application of mathematical knowledge to biomedical fields in the three main stages of Biomedical Research: basic, translational and clinical

Endogenous development: a model for the process of man-environment transaction

Iran is currently subject to a number of adverse factors affecting good development in the built environment: population explosion, oil- dependent economy, finite resources, war and natural disasters, etc. The object of the study is to research a development model appropriate to the Country's needs for a proactive system of building environment. This model is not specific to Iran and, as the case studies and the discourse of the thesis indicate, is universal. However, the author suggests that the validity of development approaches will not be determined as a result of theoretical and ideological debate but in the realm of practice. Therefore, he has explored diverse ways in which professionals in the built environment can provide an analytical survey of the problems that beset them. An attempt has been made to bring these various elements into perspective and offer a model of 'endogenous development'.The process for achieving a viable, exciting and humane built environment is very complex and calls for contributions from many individuals and small multi -disciplinary groups. Beside professionals contributions (which is accomplished by deduction inference), there is a need for people's participation in design process (which is accomplished either by deduction or by abduction inferences). This participatory approach can also help shifting the process of design towards a wider domain that of the 'production process' (which is accomplished by abduction and induction inferences). Production process is the first paradigm of the model of endogenous development and is a manifestation of a feedback mechanism and acts as an open - ended living system. The second is 'supply- demand' paradigm which shows the relationships between the components of a system or between different systems in surface- structuresThis model is directed at society's development, not just its economic growth, but it does not preclude the possibility of such growth. The reduction of the problems' effect in an endogenous development is viewed more as a way of improving the quality of life than of increasing the standard of living. Nowadays, people are passive recipients in the consumer society and are totally dependent on others for their survival. This style of living is assumed to project an image of economic development and higher productivity, but there is a confrontation of preadjusted commodities which are the products of others. That is because the process of production is not natural (i.e. a closed loop cyclic process via feedback control). It is artificial (i.e. an open -loop linear process via a feed -forward control) which may not help satisfying the user's needs and wants entirely. In the built environment, the great majority have no say in the planning and design of their homes or places of work.Accordingly, endogenous development offers a framework within which the necessity of employing the people's creative power in building their environment is explained. It is based on the assumption that each individual and society's knowledge and experiences play a central and mediating role between professionals' perceptions of the environment and a series of preferences judgements or choices they might make towards and within that environment. Indigenous knowledge and cultural attributes of traditional societies and the organizational capabilities of traditional polities are essential in qualification of the development plans, which are also evaluated and assessed by this proposed framework

Centrality in the structure of built environment: a study in the structural transformation of society and space

Born out of a long term interest in thought and social values and nearly ten years of involvement in space and design as a student of architecture and urban design, this dissertation aims to make a contribution to both the structural theory of the transformation of society and space and to our knowledge of the principle of centrality in the structure of built environment. It looks at the concept of centrality in the Iranian city of Meshed. However, this is not intended as a study of a unique experience. Rather the spatial and temporal co- ordinates of the text, Islam and Iran, and the historical period of Modernist thought, offer a framework within which theoretical and principal questions of a more general nature concerning the structural character of society and space can be explored.The emphasis throughout is on the concept of the social production of the built environment at the centre of which lies the ideal process, understood in its most general sense as purposeful human activity. The dissertation seeks to show how changes in the relations between the elements and actors of production, the physical and mental means by which the built environment is created, and the relation between moment and totality within which the production process occurs, are central to an understanding of the structural transformation of human society, the form of city and the organization of space

MORPHOLOGIC ANALYSES OF PALEOZOIC RHOMBIFERAN ECHINODERM STEMS

During the Paleozoic, echinoderms exhibited a diverse array of morphologies. This work specifically deals with an extinct stemmed group called glyptocystitoid rhombiferans. The goal of this work is to investigate functional morphology of the stem in this enigmatic group. Abnormalities in form are addressed herein by a brief literature review of teratologic features and in the description of a new species of pleurocystitid Pleurocystites? scylla. Morphologic specialization is discussed in the investigation of the internal structure and morphometrics of the mesotem of Brockocystis. Linear morphometrics, multiple imputation, and multivariate statistics were used to describe the variability exhibited in a single element with ontogenetic implications. The mesostem structure is highly biologically controlled in its calcification and appears to originate in the midstem region. Finally, computational fluid dynamics was used to test various hypothesized posture models of the generalized motile bauplan. Simulated posture models found a buried life mode was most unstable and unrealistic. The coiled or Snake posture model was the most stable at a velocity of 0.05 m/s. From these findings, new information regarding the development, growth, and life mode of glyptocystitoid rhombiferan echinoderms is elucidated

Effect of the production environment on the production efficiency of Bonsmara cows in South Africa

The production environment is known to have a large influence on extensively managed beef cows. A better understanding of the relationship between the beef cow and her environment should be useful in the pursuit of improving beef cow efficiency. The influence of the production environment on the efficiency of extensively managed Bonsmara cows was investigated through a series of research objectives. It was found that VEGMAP’s bioregion classification system can be used to describe the South African beef production regions. The environmental characteristics with the potential to influence beef cow efficiency were identified as temperature, rainfall, cation exchange capacity, soil pH, soil organic carbon, soil P and grazing capacity. A dataset was created that contains the historical cow production records for every Bonsmara breeder. GIS tools were then used to link the cow production records with the production region in which the farm is located, as well as the environmental characteristics for that specific location. The combined dataset was then statistically analysed to investigate the research objectives. The influence of the geographic location, production region and breeder on Bonsmara production traits was investigated by cluster analysis and ANOVA. Results from ANOVA indicate that production region has a statistically significant (p < 0.05) influence on production traits. The influence of the breeders on the same production traits was, however, statistically much larger (p < 0.0001) than production region. Bonsmara production traits are therefore influenced to a greater extent by the breeders rather than production environment. Stepwise regression analysis was used to determine the influence of the combined environment on production traits. The combined environment has a statistically significant (p < 0.0001) influence on all the production traits. The results indicate that the extent of the influence of the environment on production change through the growth curve. The environment’s influence was the greatest at weaning (9%) and yearling age (10%). Bonsmara weaning and yearling weights therefore show the largest potential for manipulation through management. The influence of individual environmental characteristics on all the Bonsmara cow production traits was then investigated by the same stepwise regression analysis. Most of the environmental characteristics were found to have a statistically significant (p < 0.0001) influence on the production traits. Rainfall and temperature had the largest influence on Bonsmara production traits. The negative influence of rainfall was attributed to the influence of rainfall on the quality of the grazing. The influence of temperature on production traits was small. The small negative influence of temperature could indicate that Bonsmara cows are well adapted to the main South African beef production regions. Finally, the relationship between Bonsmara cow size and reproduction was investigated by linear regression analysis. Results indicate that larger Bonsmara cows are to some extent more reproductive than smaller cows. The study confirmed that production environment influences beef cow efficiency. Bonsmara breeders however have a much larger influence on the efficiency of their cows through the implementation of management practices and breeding objectives.Dissertation (MSc(Agric))--University of Pretoria, 2012.Animal and Wildlife Sciencesunrestricte