Implantable Wireless Sensor Networks: Application to Measuring Temperature for In Vivo Detection of Infections

It is has been proven that infection in the body cause a local temperature increase due to localized inflammation. Therefore, a method to provide early diagnostic or long-term tracking of this infection will provide great benefits to patients with diabetic foot ulcers or sickle cell disease, and those receiving hemodialysis where they suffer from a weakened immune system. The goal of this project is to develop an implantable wireless temperature sensor based on a wireless sensor network system for monitoring infections in situ. The analog signals from the thermistors are digitized and wirelessly transmitted to a computer with an ez430-rf2500 wireless sensor network (Texas Instruments). The sensor device is designed to monitor temperature at a fixation plate of a rodent under an infection model. Two prototypes of the system, T1 and T2, were designed and fabricated during this work. The sensors displayed good sensitivity, stability and reliability during the testing. The system was optimized for better timing accuracy to allow power management. Such a sensor could be used for long term monitoring of infections associated with orthopedic implants

Wireless Technologies for Implantable Devices

Wireless technologies are incorporated in implantable devices since at least the 1950s. With remote data collection and control of implantable devices, these wireless technologies help researchers and clinicians to better understand diseases and to improve medical treatments. Today, wireless technologies are still more commonly used for research, with limited applications in a number of clinical implantable devices. Recent development and standardization of wireless technologies present a good opportunity for their wider use in other types of implantable devices, which will significantly improve the outcomes of many diseases or injuries. This review briefly describes some common wireless technologies and modern advancements, as well as their strengths and suitability for use in implantable medical devices. The applications of these wireless technologies in treatments of orthopedic and cardiovascular injuries and disorders are described. This review then concludes with a discussion on the technical challenges and potential solutions of implementing wireless technologies in implantable devices

A WIRELESS SENSOR SYSTEM WITH DIGITALLY CONTROLLED SIGNAL CONDITIONING CIRCUIT FOR FORCE MONITORING AT BONE FIXATION PLATES

Post-rehabilitation of orthopedic surgery is critical for bone fracture treatments. Current protocols are not based on quantitative assessments of the patient condition but they are conservative estimations mostly based on prior experience and physician’s opinions. While there are quantitative methods for assessing the recovery of orthopedic surgery, they are typically very expensive and provide only snapshots during the healing process. A standalone, reconfigurable, embedded wireless sensor system with digitally controlled signal conditioning system capable of providing continuous monitoring of bone healing is developed. Strain sensor measurements were validated against a commercial mechanical loading instrument for relevant loads that an animal (ovine) would experience during in vivo testing (up to 250 N). The loader was configured to apply a maximum force of 250 N to the bone fixation plate at a rate of 1000 N/min. Cyclic testing of the system showed optimal stability and no observable drift in the sensor. The sensor was also implemented in a rodent model for monitoring force loading at an internal bone fixation plate. The platform’s small, robust, and low power nature is usefulness for continuous wireless monitoring and actuation in many biomedical applications

Silicon-on-insulator-based complementary metal oxide semiconductor integrated optoelectronic platform for biomedical applications

Microscale optical devices enabled by wireless power harvesting and telemetry facilitate manipulation and testing of localized biological environments (e.g., neural recording and stimulation, targeted delivery to cancer cells). Design of integrated microsystems utilizing optical power harvesting and telemetry will enable complex in vivo applications like actuating a single nerve, without the difficult requirement of extreme optical focusing or use of nanoparticles. Silicon-on-insulator (SOI)-based platforms provide a very powerful architecture for such miniaturized platforms as these can be used to fabricate both optoelectronic and microelectronic devices on the same substrate. Near-infrared biomedical optics can be effectively utilized for optical power harvesting to generate optimal results compared with other methods (e.g., RF and acoustic) at submillimeter size scales intended for such designs. We present design and integration techniques of optical power harvesting structures with complementary metal oxide semiconductor platforms using SOI technologies along with monolithically integrated electronics. Such platforms can become the basis of optoelectronic biomedical systems including implants and lab-on-chip systems

Um novo modelo de conceito para implantes ortopédicos instrumentados ativos

Doutoramento em Engenharia MecânicaTotal hip replacement (THR) is one of the most performed surgical procedures around the world. Millions of THR are carried out worldwide each year. Currently, THR revision rates can be higher than 10%. A significant increase of the number of primary and revision THRs, mainly among patients less than 65 years old (including those under 45 years old) has been predicted for the forthcoming years. A worldwide increase in the use of uncemented fixation has also been reported, incidence caused mainly by the significant increase of more active and/or younger patients. Besides the significant breakthroughs for uncemented fixations, they have not been able to ensure long-term implant survival. Up to date, current implant models have shown evidences of their inability to avoid revision procedures. The performance of implants will be optimized if they are designed to perform an effective control over the osseointegration process. To pursue this goal, improved surgical techniques and rehabilitation protocols, innovative bioactive coatings (including those for controlled delivery of drugs and/or other bio-agents in the bone-implant interface), the concepts of Passive Instrumented Implant and Active Instrumented Implant have been proposed. However, there are no conclusive demonstrations of the effectiveness of such methodologies. The main goal of this thesis is to propose a new concept model for instrumented implants to optimize the bone-implant integration: the self-powered instrumented active implant with ability to deliver controlled and personalized biophysical stimuli to target tissue areas. The need of such a new model is demonstrated by optimality analyses conducted to study the performance of instrumented and non-instrumented orthopaedic implants. Promising results on the potential of a therapeutic actuation driven by cosurface-based capacitive stimulation were achieved, as well as for self-powering instrumented active implants by magnetic levitation-based electromagnetic energy harvesting.A artroplastia total da anca (THR) é um dos procedimentos cirúrgicos mais realizados à escala global. Milhões de THRs são realizadas todos os anos em todo o mundo. Atualmente, as taxas de revisão destas artroplastias podem ser superiores a 10%. O número de THRs primárias e de revisão têm aumentado e estima-se que cresçam acentuadamente nos próximos anos, principalmente em pacientes com idades inferiores a 65 anos (incluindo aqueles com menos de 45 anos). Também se tem verificado uma tendência generalizada para o uso de fixações não cimentadas, incidência principalmente causada pelo aumento significativo de pacientes mais jovens e/ou activos. Embora se tenham realizado avanços científicos no projeto de implantes não cimentados, têm-se verificado o seu insucesso a longo-prazo. Encontram-se evidências da ineficácia dos modelos de implantes que têm sido desenvolvidos para evitar procedimentos de revisão. O desempenho dos implantes será otimizado se estes foram projetados para controlarem eficazmente o processo de osseointegração. Para se alcançar este objetivo, têm sido propostas a melhoria das técnicas cirúrgicas e dos protocolos de reabilitação, a inovação dos revestimentos (onde se incluem os revestimentos ativos projetados para a libertação controlada de fármacos e/ou outros bio-agentes) e os conceitos de Implante Instrumentado Passivo e Implante Instrumentado Ativo. Contudo, não existem demonstrações conclusivas da eficácia de tais metodologias. O principal objetivo desta tese é propor um novo modelo de conceito para implantes instrumentados para se otimizar a integração osso-implante: o implante instrumentado ativo, energeticamente auto-suficiente, com capacidade de aplicar estímulos biofísicos em tecidos-alvo de forma controlada e personalizada. A necessidade de um novo modelo é demonstrada através da realização de análises de otimalidade ao desempenho dos implantes instrumentados e não-instrumentados. Foram encontrados resultados promissores para o controlo otimizado da osseointegração usando este novo modelo, através da atuação terapêutica baseada na estimulação capacitiva com arquitetura em co-superfície, assim como para fornecer energia elétrica de forma autónoma por mecanismos de transdução baseados em indução eletromagnética usando configurações baseadas na levitação magnética

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development

WiForceSticker: Batteryless, Thin Sticker-like Flexible Force Sensor

Any two objects in contact with each other exert a force that could be simply due to gravity or mechanical contact, such as a robotic arm gripping an object or even the contact between two bones at our knee joints. The ability to naturally measure and monitor these contact forces allows a plethora of applications from warehouse management (detect faulty packages based on weights) to robotics (making a robotic arms' grip as sensitive as human skin) and healthcare (knee-implants). It is challenging to design a ubiquitous force sensor that can be used naturally for all these applications. First, the sensor should be small enough to fit in narrow spaces. Next, we don't want to lay cumbersome cables to read the force values from the sensors. Finally, we need to have a battery-free design to meet the in-vivo applications. We develop WiForceSticker, a wireless, battery-free, sticker-like force sensor that can be ubiquitously deployed on any surface, such as all warehouse packages, robotic arms, and knee joints. WiForceSticker first designs a tiny $4$~mm~$\times$~$2$~mm~$\times$~$0.4$~mm capacitative sensor design equipped with a $10$~mm~$\times$~$10$~mm antenna designed on a flexible PCB substrate. Secondly, it introduces a new mechanism to transduce the force information on ambient RF radiations that can be read by a remotely located reader wirelessly without requiring any battery or active components at the force sensor, by interfacing the sensors with COTS RFID systems. The sensor can detect forces in the range of $0$-$6$~N with sensing accuracy of $<0.5$~N across multiple testing environments and evaluated with over $10,000$ varying force level presses on the sensor. We also showcase two application case studies with our designed sensors, weighing warehouse packages and sensing forces applied by bone joints