Acute lung injury in paediatric intensive care: course and outcome

Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) carry a high morbidity and mortality (10-90%). ALI is characterised by non-cardiogenic pulmonary oedema and refractory hypoxaemia of multifactorial aetiology [1]. There is limited data about outcome particularly in children. Methods This retrospective cohort study of 85 randomly selected patients with respiratory failure recruited from a prospectively collected database represents 7.1% of 1187 admissions. They include those treated with High Frequency Oscillation Ventilation (HFOV). The patients were admitted between 1 November 1998 and 31 October 2000. Results: Of the 85, 49 developed acute lung injury and 47 had ARDS. There were 26 males and 23 females with a median age and weight of 7.7 months (range 1 day-12.8 years) and 8 kg (range 0.8-40 kg). There were 7 deaths giving a crude mortality of 14.3%, all of which fulfilled the Consensus I [1] criteria for ARDS. Pulmonary occlusion pressures were not routinely measured. The A-a gradient and PaO2/FiO2 ratio (median + [95% CI]) were 37.46 [31.82-43.1] kPa and 19.12 [15.26-22.98] kPa respectively. The non-survivors had a significantly lower PaO2/FiO2 ratio (13 [6.07-19.93] kPa) compared to survivors (23.85 [19.57-28.13] kPa) (P = 0.03) and had a higher A-a gradient (51.05 [35.68-66.42] kPa) compared to survivors (36.07 [30.2-41.94]) kPa though not significant (P = 0.06). Twenty-nine patients (59.2%) were oscillated (Sensormedics 3100A) including all 7 non-survivors. There was no difference in ventilation requirements for CMV prior to oscillation. Seventeen of the 49 (34.7%) were treated with Nitric Oxide including 5 out of 7 non-survivors (71.4%). The median (95% CI) number of failed organs was 3 (1.96-4.04) for non-survivors compared to 1 (0.62-1.62) for survivors (P = 0.03). There were 27 patients with isolated respiratory failure all of whom survived. Six (85.7%) of the non-survivors also required cardiovascular support.Conclusion: A crude mortality of 14.3% compares favourably to published data. The A-a gradient and PaO2/FiO2 ratio may be of help in morbidity scoring in paediatric ARDS. Use of Nitric Oxide and HFOV is associated with increased mortality, which probably relates to the severity of disease. Multiple organ failure particularly respiratory and cardiac disease is associated with increased mortality. ARDS with isolated respiratory failure carries a good prognosis in children

Probing Classifiers are Unreliable for Concept Removal and Detection

Neural network models trained on text data have been found to encode undesirable linguistic or sensitive concepts in their representation. Removing such concepts is non-trivial because of a complex relationship between the concept, text input, and the learnt representation. Recent work has proposed post-hoc and adversarial methods to remove such unwanted concepts from a model's representation. Through an extensive theoretical and empirical analysis, we show that these methods can be counter-productive: they are unable to remove the concepts entirely, and in the worst case may end up destroying all task-relevant features. The reason is the methods' reliance on a probing classifier as a proxy for the concept. Even under the most favorable conditions for learning a probing classifier when a concept's relevant features in representation space alone can provide 100% accuracy, we prove that a probing classifier is likely to use non-concept features and thus post-hoc or adversarial methods will fail to remove the concept correctly. These theoretical implications are confirmed by experiments on models trained on synthetic, Multi-NLI, and Twitter datasets. For sensitive applications of concept removal such as fairness, we recommend caution against using these methods and propose a spuriousness metric to gauge the quality of the final classifier

Computational Methods for Medical and Cyber Security

Over the past decade, computational methods, including machine learning (ML) and deep learning (DL), have been exponentially growing in their development of solutions in various domains, especially medicine, cybersecurity, finance, and education. While these applications of machine learning algorithms have been proven beneficial in various fields, many shortcomings have also been highlighted, such as the lack of benchmark datasets, the inability to learn from small datasets, the cost of architecture, adversarial attacks, and imbalanced datasets. On the other hand, new and emerging algorithms, such as deep learning, one-shot learning, continuous learning, and generative adversarial networks, have successfully solved various tasks in these fields. Therefore, applying these new methods to life-critical missions is crucial, as is measuring these less-traditional algorithms' success when used in these fields

Computational intelligence approaches to robotics, automation, and control [Volume guest editors]

No abstract available

Control of high harmonic generation by manipulation of field parameters

?High harmonic generation is a well established technique to investigate the structure and the inner dynamics of atoms and molecules. This thesis describes how the generating field parameters can be manipulated to extend the limits imposed on the technique by the use of traditional laser sources. In this field, with traditional source we mean high intensity, linearly polarised laser pulses at 800 nm. The first parameter to be investigated is the wavelength λ of the generating beam. The unfavourable scaling of the high harmonic yield with λ seems to suggest that high harmonic spectroscopy of atoms and molecules should be restricted to the wavelengths that obviate this problem, and that therefore shorter wavelength should be used. But longer wavelengths, in the mid infrared, present a great advantage respect to shorter ones. The maximum harmonic order that we can obtain is proportional to the ionisation potential of the target and to the wavelength times the intensity of the beam, so a higher number of harmonic can be produced with a longer wavelength than with short, the intensity being equal. This becomes incredibly valuable when the specie under investigation is a molecule with low ionisation potential. To produce high harmonics, a linearly polarised beam is required. If ellipticity is introduced in the beam, the harmonic signal quickly fades out, as non-linearly polarisation in monochromatic beams switches off the mechanism at the basis of high harmonic generation. This is not true if the polarisation of the beam is changed through the introduction of an additional laser beam, perpendicularly polarised respect to the fundamental. In this thesis the additional degree of freedom that this second field implies is investigated by combining the fundamental with its second harmonic and by controlling the relative delay of the two with sub-cycle precision. The key result is that the addition of the second harmonic gives access to the control of the harmonic amplitude and to the time at which the high harmonics are emitted, by simply controlling the relative phase between the two pulses

Discover, recycle and reuse frequent patterns in association rule mining

Ph.DDOCTOR OF PHILOSOPH