33,021 research outputs found
On combinatorial optimisation in analysis of protein-protein interaction and protein folding networks
Abstract: Protein-protein interaction networks and protein folding networks represent prominent research topics at the intersection of bioinformatics and network science. In this paper, we present a study of these networks from combinatorial optimisation point of view. Using a combination of classical heuristics and stochastic optimisation techniques, we were able to identify several interesting combinatorial properties of biological networks of the COSIN project. We obtained optimal or near-optimal solutions to maximum clique and chromatic number problems for these networks. We also explore patterns of both non-overlapping and overlapping cliques in these networks. Optimal or near-optimal solutions to partitioning of these networks into non-overlapping cliques and to maximum independent set problem were discovered. Maximal cliques are explored by enumerative techniques. Domination in these networks is briefly studied, too. Applications and extensions of our findings are discussed
A Review on Biological Inspired Computation in Cryptology
Cryptology is a field that concerned with cryptography and cryptanalysis. Cryptography, which is a key technology in providing a secure transmission of information, is a study of designing strong cryptographic algorithms, while cryptanalysis is a study of breaking the cipher. Recently biological approaches provide inspiration in solving problems from various fields. This paper reviews major works in the application of biological inspired computational (BIC) paradigm in cryptology. The paper focuses on three BIC approaches, namely, genetic algorithm (GA), artificial neural network (ANN) and artificial immune system (AIS). The findings show that the research on applications of biological approaches in cryptology is minimal as compared to other fields. To date only ANN and GA have been used in cryptanalysis and design of cryptographic primitives and protocols. Based on similarities that AIS has with ANN and GA, this paper provides insights for potential application of AIS in cryptology for further research
Towards Smart Hybrid Fuzzing for Smart Contracts
Smart contracts are Turing-complete programs that are executed across a
blockchain network. Unlike traditional programs, once deployed they cannot be
modified. As smart contracts become more popular and carry more value, they
become more of an interesting target for attackers. In recent years, smart
contracts suffered major exploits, costing millions of dollars, due to
programming errors. As a result, a variety of tools for detecting bugs has been
proposed. However, majority of these tools often yield many false positives due
to over-approximation or poor code coverage due to complex path constraints.
Fuzzing or fuzz testing is a popular and effective software testing technique.
However, traditional fuzzers tend to be more effective towards finding shallow
bugs and less effective in finding bugs that lie deeper in the execution. In
this work, we present CONFUZZIUS, a hybrid fuzzer that combines evolutionary
fuzzing with constraint solving in order to execute more code and find more
bugs in smart contracts. Evolutionary fuzzing is used to exercise shallow parts
of a smart contract, while constraint solving is used to generate inputs which
satisfy complex conditions that prevent the evolutionary fuzzing from exploring
deeper paths. Moreover, we use data dependency analysis to efficiently generate
sequences of transactions, that create specific contract states in which bugs
may be hidden. We evaluate the effectiveness of our fuzzing strategy, by
comparing CONFUZZIUS with state-of-the-art symbolic execution tools and
fuzzers. Our evaluation shows that our hybrid fuzzing approach produces
significantly better results than state-of-the-art symbolic execution tools and
fuzzers
AI Solutions for MDS: Artificial Intelligence Techniques for Misuse Detection and Localisation in Telecommunication Environments
This report considers the application of Articial Intelligence (AI) techniques to
the problem of misuse detection and misuse localisation within telecommunications
environments. A broad survey of techniques is provided, that covers inter alia
rule based systems, model-based systems, case based reasoning, pattern matching,
clustering and feature extraction, articial neural networks, genetic algorithms, arti
cial immune systems, agent based systems, data mining and a variety of hybrid
approaches. The report then considers the central issue of event correlation, that
is at the heart of many misuse detection and localisation systems. The notion of
being able to infer misuse by the correlation of individual temporally distributed
events within a multiple data stream environment is explored, and a range of techniques,
covering model based approaches, `programmed' AI and machine learning
paradigms. It is found that, in general, correlation is best achieved via rule based approaches,
but that these suffer from a number of drawbacks, such as the difculty of
developing and maintaining an appropriate knowledge base, and the lack of ability
to generalise from known misuses to new unseen misuses. Two distinct approaches
are evident. One attempts to encode knowledge of known misuses, typically within
rules, and use this to screen events. This approach cannot generally detect misuses
for which it has not been programmed, i.e. it is prone to issuing false negatives.
The other attempts to `learn' the features of event patterns that constitute normal
behaviour, and, by observing patterns that do not match expected behaviour, detect
when a misuse has occurred. This approach is prone to issuing false positives,
i.e. inferring misuse from innocent patterns of behaviour that the system was not
trained to recognise. Contemporary approaches are seen to favour hybridisation,
often combining detection or localisation mechanisms for both abnormal and normal
behaviour, the former to capture known cases of misuse, the latter to capture
unknown cases. In some systems, these mechanisms even work together to update
each other to increase detection rates and lower false positive rates. It is concluded
that hybridisation offers the most promising future direction, but that a rule or state
based component is likely to remain, being the most natural approach to the correlation
of complex events. The challenge, then, is to mitigate the weaknesses of
canonical programmed systems such that learning, generalisation and adaptation
are more readily facilitated
A systematic review of data quality issues in knowledge discovery tasks
Hay un gran crecimiento en el volumen de datos porque las organizaciones capturan permanentemente la cantidad colectiva de datos para lograr un mejor proceso de toma de decisiones. El desafĂo mas fundamental es la exploraciĂłn de los grandes volĂşmenes de datos y la extracciĂłn de conocimiento Ăştil para futuras acciones por medio de tareas para el descubrimiento del conocimiento; sin embargo, muchos datos presentan mala calidad. Presentamos una revisiĂłn sistemática de los asuntos de calidad de datos en las áreas del descubrimiento de conocimiento y un estudio de caso aplicado a la enfermedad agrĂcola conocida como la roya del cafĂ©.Large volume of data is growing because the organizations are continuously capturing the collective amount of data for better decision-making process. The most fundamental challenge is to explore the large volumes of data and extract useful knowledge for future actions through knowledge discovery tasks, nevertheless many data has poor quality. We presented a systematic review of the data quality issues in knowledge discovery tasks and a case study applied to agricultural disease named coffee rust
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