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A survey of simulation techniques in commerce and defence
Despite the developments in Modelling and Simulation (M&S) tools and techniques over the past years, there has been a gap in the M&S research and practice in healthcare on developing a toolkit to assist the modellers and simulation practitioners with selecting an appropriate set of techniques. This study is a preliminary step towards this goal. This paper presents some results from a systematic literature survey on applications of M&S in the commerce and defence domains that could inspire some improvements in the healthcare. Interim results show that in the commercial sector Discrete-Event Simulation (DES) has been the most widely used technique with System Dynamics (SD) in second place. However in the defence sector, SD has gained relatively more attention. SD has been found quite useful for qualitative and soft factors analysis. From both the surveys it becomes clear that there is a growing trend towards using hybrid M&S approaches
Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening
This work introduces a number of algebraic topology approaches, such as
multicomponent persistent homology, multi-level persistent homology and
electrostatic persistence for the representation, characterization, and
description of small molecules and biomolecular complexes. Multicomponent
persistent homology retains critical chemical and biological information during
the topological simplification of biomolecular geometric complexity.
Multi-level persistent homology enables a tailored topological description of
inter- and/or intra-molecular interactions of interest. Electrostatic
persistence incorporates partial charge information into topological
invariants. These topological methods are paired with Wasserstein distance to
characterize similarities between molecules and are further integrated with a
variety of machine learning algorithms, including k-nearest neighbors, ensemble
of trees, and deep convolutional neural networks, to manifest their descriptive
and predictive powers for chemical and biological problems. Extensive numerical
experiments involving more than 4,000 protein-ligand complexes from the PDBBind
database and near 100,000 ligands and decoys in the DUD database are performed
to test respectively the scoring power and the virtual screening power of the
proposed topological approaches. It is demonstrated that the present approaches
outperform the modern machine learning based methods in protein-ligand binding
affinity predictions and ligand-decoy discrimination
Topological descriptors for 3D surface analysis
We investigate topological descriptors for 3D surface analysis, i.e. the
classification of surfaces according to their geometric fine structure. On a
dataset of high-resolution 3D surface reconstructions we compute persistence
diagrams for a 2D cubical filtration. In the next step we investigate different
topological descriptors and measure their ability to discriminate structurally
different 3D surface patches. We evaluate their sensitivity to different
parameters and compare the performance of the resulting topological descriptors
to alternative (non-topological) descriptors. We present a comprehensive
evaluation that shows that topological descriptors are (i) robust, (ii) yield
state-of-the-art performance for the task of 3D surface analysis and (iii)
improve classification performance when combined with non-topological
descriptors.Comment: 12 pages, 3 figures, CTIC 201
The wavelet transform for pre-processing IR spectra in the identification of mono- and di-substituted benzenes
This paper describes the wavelet transformation of IR spectra with the Daubechies analysing wavelet functions as a feature extracting method that successfully reduces the spectral data more than 20-fold with a significant improvement in the classification process
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